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WANG Caihong, LIU Rongxin, TANG Feng, WEI Xiaotao, XU Ziqing, HOU Huaijing, ZHANG Jie, ZHAO Yongqiang, XUE Jianjun. Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0217
Citation: WANG Caihong, LIU Rongxin, TANG Feng, WEI Xiaotao, XU Ziqing, HOU Huaijing, ZHANG Jie, ZHAO Yongqiang, XUE Jianjun. Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0217

Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

doi: 10.12290/xhyxzz.2023-0217

Gansu Provincial Science and Technology Plan Project-Construction of Clinical Medical Research Center(20JR10RA435)

  • Received Date: 2023-04-27
    Available Online: 2023-09-05
  • As a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the quality of life of patients. It is a hot and difficult point in the field of medical research. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic persistent neuroinflammation plays a key role in its development. Microglia and Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome are closely related to neuroinflammation and cognitive impairment. Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors, reduce amyloid β-protein (Aβ) deposition, regulate autophagy, maintain synaptic homeostasis, and reduce neuroinflammation. In turn, the role of prevention and treatment of cognitive impairment. Therefore, summarizing and discussing the mechanism of microglia, NLRP3 inflammasome and their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism of cognitive impairment, clinical prevention and treatment of cognitive impairment, and the subsequent development of more efficient drugs.
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