Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

WANG Caihong; LIU Rongxin; TANG Feng; WEI Xiaotao; XU Ziqing; HOU Huaijing; ZHANG Jie; ZHAO Yongqiang; XUE Jianjun

doi:10.12290/xhyxzz.2023-0217

Volume 14 Issue 6

Nov. 2023

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Medical Journal of Peking Union Medical College Hospital > 2023 > 14(6): 1282-1288. > DOI: 10.12290/xhyxzz.2023-0217

WANG Caihong, LIU Rongxin, TANG Feng, WEI Xiaotao, XU Ziqing, HOU Huaijing, ZHANG Jie, ZHAO Yongqiang, XUE Jianjun. Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1282-1288. DOI: 10.12290/xhyxzz.2023-0217

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Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

WANG Caihong¹,
LIU Rongxin¹,
TANG Feng¹,
WEI Xiaotao¹,
XU Ziqing^{2, 3, 4},
HOU Huaijing^{2, 3, 4},
ZHANG Jie^{2, 3, 4},
ZHAO Yongqiang^5, ,,
XUE Jianjun^{2, 3, 4, ,}

1.
First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, China
2.
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
3.
Gansu Province Integrative Medicine Anesthesia Clinical Research Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
4.
Gansu Provincial Institute of Traditional Chinese and Western Medicine Anesthesia and Evidence-based Medicine Institute, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
5.
Department of Urology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China

Funds:

Gansu Provincial Science and Technology Plan Project-Construction of Clinical Medical Research Center 20JR10RA435

Gansu Provincial Science and Technology Plan Project -Key Research and Development Plan 22YF7FA101

More Information

Corresponding author:
ZHAO Yongqiang, E-mail: 1114221808@qq.com

XUE Jianjun, E-mail: xjjfei419@163.com
Received Date: April 26, 2023
Accepted Date: July 06, 2023
Available Online: September 03, 2023
Issue Publish Date: November 29, 2023

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Abstract

Abstract

As a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the patients' quality of life. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic persistent neuroinflammation plays a key role in its development. Microglia and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome are closely related to neuroinflammation and cognitive impairment. Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors, reduce amyloid β-protein(Aβ) deposition, regulate autophagy, maintain synaptic homeostasis, thus reducing neuroinflammation and further preventing and treating cognitive impairment. Therefore, exploring the mechanism of microglia and NLRP3 inflammasome as well as their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism and clinical prevention and treatment of cognitive impairment, and the subsequent development of more efficient drugs.
- microglia,
- NLRP3 inflammasome,
- cognitive dysfunction,
- neuroinflammation,
- research progress

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