Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function

Inflammasomes are cytosolic innate immune complexes, in which NLRP3 plays a very important role in inducing inflammation as an inflammasome sensor for membrane damage. When infection is perceived, they recruit ASC adapters and assemble into large inflammatory complexes. Pyroptosis is a programmed form of cell death that relies on the cleavage of the Gasdermin D (GSDMD) protein triggered by the caspasate protease in the cytoplasm, and the activated GSDMD forms membrane pores in the cell membrane, ultimately leading to the rupture of the cytoplasmic membrane and a broader inflammatory response. This article briefly summarizes the relationship between NLRP3 inflammasome and pyroptosis, and analyzes the relationship between NLRP3 and coagulation function, aiming to provide new ideas for intervening in DIC caused by the abnormal increase of inflammasomes.