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Volume 15 Issue 6
Nov.  2024
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GAO Jiawei, DENG Xinkai, HAN Xiaobo, LI Xiao, CHAI Yahao, ZHANG Lei. Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(6): 1395-1400. DOI: 10.12290/xhyxzz.2024-0012
Citation: GAO Jiawei, DENG Xinkai, HAN Xiaobo, LI Xiao, CHAI Yahao, ZHANG Lei. Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(6): 1395-1400. DOI: 10.12290/xhyxzz.2024-0012
shu

Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function

  • 1.

    School of Postgraduates, Xinjiang Medical University, Urumqi 830054, China

  • 2.

    Department of Emergency Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, China

Funds: 

Xinjiang Uygur Autonomous Region Natural Science Foundation 2022D01C645

Xinjiang Uygur Autonomous Region Natural Science Foundation 2020D01A139

More Information
  • Corresponding author:

    ZHANG Lei, E-mail: zhanglei19716240@163.com

  • Received Date: January 05, 2024
  • Accepted Date: February 21, 2024
  • Available Online: June 19, 2024
  • Issue Publish Date: November 29, 2024
    Graphical Abstract
    • Abstract

  • Disseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate pyroptosis and then release interleukin (IL)-1β and IL-18, which further activates platelets and the coagulation system and exacerbates inflammatory responses and coagulation processes, thus creating great uncertainty for the treatment and prognosis of sepsis. This article aims to review the correlation between the inflammasome and pyroptosis, as well as their impact on coagulation function, in hope of providing new insights for the clinical treatment of DIC.

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