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Volume 14 Issue 4
Jul.  2023
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WU Liyi, YAN Weigang. Research Progress of Prostate Cancer Somatic Mutation and Treatment[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 839-843. DOI: 10.12290/xhyxzz.2022-0717
Citation: WU Liyi, YAN Weigang. Research Progress of Prostate Cancer Somatic Mutation and Treatment[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 839-843. DOI: 10.12290/xhyxzz.2022-0717
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Research Progress of Prostate Cancer Somatic Mutation and Treatment

  • Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National High Level Hospital Clinical Research Funding 2022-PUMCH-A-063

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  • Corresponding author:

    YAN Weigang, E-mail: ywgpumch@sina.com

  • Received Date: December 18, 2022
  • Accepted Date: January 30, 2023
  • Issue Publish Date: July 29, 2023
    Graphical Abstract
    • Abstract
  • Prostate cancer, one of the most common male malignancies in the world, seriously threatens the health of middle-aged and elderly men. The clinical manifestations and prognosis of prostate cancer patients have individual differences. Most low-risk patients have a slow disease course and a low risk of death, while intermediate- and high-risk patients have a poor prognosis and a high risk of death. Current studies have shown that prostate cancer genes have complex genetic heterogeneity associated with clinical manifestations and somatic mutation is an important part of prostate cancer genome variations. With the development of high-throughput sequencing technology, related research is increasing. This article reviews the research progress on somatic mutations in prostate cancer and treatment to provide reference for prognosis prediction and drug treatment of the disease.
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    • References (35)
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