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Volume 14 Issue 3
May  2023
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TIAN Meng, WU Guobing, YANG Jin, OUYANG Jing, CHANG Hong, LIU Min, ZHENG Ya, CHEN Zhaofeng. Research Progress on the Mechanism of Gastric Microecology in the Development of Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 581-585. DOI: 10.12290/xhyxzz.2022-0593
Citation: TIAN Meng, WU Guobing, YANG Jin, OUYANG Jing, CHANG Hong, LIU Min, ZHENG Ya, CHEN Zhaofeng. Research Progress on the Mechanism of Gastric Microecology in the Development of Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 581-585. DOI: 10.12290/xhyxzz.2022-0593
shu

Research Progress on the Mechanism of Gastric Microecology in the Development of Gastric Cancer

  • 1.

    The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China

  • 2.

    Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China

  • 3.

    Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, China

Funds: 

National Natural Science Foundation of China 81960430

Lanzhou Science and Technology Plan Project 2021-1-111

The First Hospital of Lanzhou University Hospital Fund ldyyyn2021-6

More Information
  • Corresponding author:

    CHEN Zhaofeng, E-mail: zhfchen@lzu.edu.cn

  • Received Date: October 11, 2022
  • Accepted Date: February 08, 2023
  • Available Online: April 11, 2023
  • Issue Publish Date: May 29, 2023
    Graphical Abstract
    • Abstract
  • Microecology has been shown to be closely related to digestive diseases, and most of the research on gastric microecology has focused on Helicobacter pylori. With the development of microarray and gene detection technology, in addition to Helicobacter pylori, more and more bacteria genera have been discovered, such as Actinomyces, Firmicute and Clostridium. These bacteria genera and their abundance changes have also been proved to be closely related to the occurrence and development of gastric cancer. In this paper, the role and possible mechanism of gastric microecology in the occurrence and development of gastric cancer are reviewed, with the hope of providing reference for clinical diagnosis and treatment.
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    • References (40)
  • [1]
    Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71: 209-249. DOI: 10.3322/caac.21660
    [2]
    Zhang F, Pu K, Wu Z, et al. Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north-western China[J]. Trop Med Int Health, 2021, 26: 290-300. DOI: 10.1111/tmi.13517
    [3]
    Schulz C, Schütte K, Koch N, et al. The active bacterial assemblages of the upper GI tract in individuals with and without infection[J]. Gut, 2018, 67: 216-225. DOI: 10.1136/gutjnl-2016-312904
    [4]
    Liu C, Ng SK, Ding Y, et al. Meta-analysis of mucosal microbiota reveals universal microbial signatures and dysbiosis in gastric carcinogenesis[J]. Oncogene, 2022, 41: 3599-3610. DOI: 10.1038/s41388-022-02377-9
    [5]
    Liu C, Wang Y, Shi J, et al. The status and progress of first-line treatment against infection: a review[J]. Therap Adv Gastroenterol, 2021, 14: 1756284821989177. http://pubmed.ncbi.nlm.nih.gov/34262609/
    [6]
    Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, et al. Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota[J]. Gut, 2018, 67: 226-236. DOI: 10.1136/gutjnl-2017-314205
    [7]
    Tseng CH, Lin JT, Ho HJ, et al. Gastric microbiota and predicted gene functions are altered after subtotal gastrec-tomy in patients with gastric cancer[J]. Sci Rep, 2016, 6: 20701. DOI: 10.1038/srep20701
    [8]
    Kumar S, Patel GK, Ghoshal UC. Helicobacter pylori-induced inflammation: possible factors modulating the risk of gastric cancer[J]. Pathogens, 2021, 10: 1099. DOI: 10.3390/pathogens10091099
    [9]
    Rajilic-Stojanovic M, Figueiredo C, Smet A, et al. Systematic review: gastric microbiota in health and disease[J]. Aliment Pharmacol Ther, 2020, 51: 582-602. DOI: 10.1111/apt.15650
    [10]
    Ierardi E, Losurdo G, Mileti A, et al. The Puzzle of Coccoid Forms of Helicobacter pylori: Beyond Basic Science[J]. Antibiotics, 2020, 9: 293. DOI: 10.3390/antibiotics9060293
    [11]
    Sharndama HC, Mba IE. Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms[J]. Braz J Microbiol, 2022, 53: 33-50. DOI: 10.1007/s42770-021-00675-0
    [12]
    Mommersteeg MC, Simovic I, Yu B, et al. Autophagy mediates ER stress and inflammation in-related gastric cancer[J]. Gut Microbes, 2022, 14: 2015238. DOI: 10.1080/19490976.2021.2015238
    [13]
    Bakhti SZ, Latifi-Navid S. Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis[J]. BMC Microbiol, 2021, 21: 258. DOI: 10.1186/s12866-021-02315-x
    [14]
    Karkhah A, Ebrahimpour S, Rostamtabar M, et al. Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases[J]. Microbiol Res, 2019, 218: 49-57. DOI: 10.1016/j.micres.2018.09.011
    [15]
    Yu G, Hu N, Wang L, et al. Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China[J]. Int J Cancer, 2017, 141: 45-51. DOI: 10.1002/ijc.30700
    [16]
    Miftahussurur M, Waskito LA, El-Serag HB, et al. Gastric microbiota and Helicobacter pylori in Indonesian population[J]. Helicobacter, 2020, 25: e12695. DOI: 10.1111/hel.12695
    [17]
    Biagi E, Nylund L, Candela M, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians[J]. PLoS One, 2010, 5: e10667. DOI: 10.1371/journal.pone.0010667
    [18]
    Zhang X, Li C, Cao W, et al. Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages[J]. Front Cell Infect Microbiol, 2021, 11: 559148. DOI: 10.3389/fcimb.2021.559148
    [19]
    Guo Y, Zhang Y, Gerhard M, et al. Effect of on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer[J]. Gut, 2020, 69: 1598-1607. DOI: 10.1136/gutjnl-2019-319696
    [20]
    Sung JJY, Coker OO, Chu E, et al. Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after eradication[J]. Gut, 2020, 69: 1572-1580. DOI: 10.1136/gutjnl-2019-319826
    [21]
    Lahner E, Zagari RM, Zullo A, et al. Chronic atrophic gastritis: Natural history, diagnosis and therapeutic manage-ment. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive Endoscopists[AIGO], the Italian Society of Digestive Endoscopy[SIED], the Italian Society of Gastroenterology[SIGE], and the Italian Society of Internal Medicine[SIMI][J]. Dig Liver Dis, 2019, 51: 1621-1632.
    [22]
    Parsons BN, Ijaz UZ, D'Amore R, et al. Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoim-mune atrophic gastritis and proton pump inhibitor use[J]. PLoS Pathog, 2017, 13: e1006653. DOI: 10.1371/journal.ppat.1006653
    [23]
    Schulz C, Schütte K, Mayerle J, et al. The role of the gastric bacterial microbiome in gastric cancer: and beyond[J]. Therap Adv Gastroenterol, 2019, 12: 1756284819894062. http://pubmed.ncbi.nlm.nih.gov/31897087/
    [24]
    Liu J, Xue Y, Zhou L. Detection of gastritis-associated patho-gens by culturing of gastric juice and mucosa[J]. Int J Clin Exp Pathol, 2018, 11: 2214-2220. http://pubmed.ncbi.nlm.nih.gov/31938333/
    [25]
    Passet V, Brisse S. Description of Klebsiella grimontii sp. nov[J]. Int J Syst Evol Microbiol, 2018, 68: 377-381. DOI: 10.1099/ijsem.0.002517
    [26]
    Muto M, Hitomi Y, Ohtsu A, et al. Acetaldehyde produc-tion by non-pathogenic Neisseria in human oral microflora: implications for carcinogenesis in upper aerodigestive tract[J]. Int J Cancer, 2000, 88: 342-350. DOI: 10.1002/1097-0215(20001101)88:3<342::AID-IJC4>3.0.CO;2-I
    [27]
    Rokkas T, Rokka A, Portincasa P. A systematic review and meta-analysis of the role of Helicobacter pylori eradication in preventing gastric cancer[J]. Ann Gastroenterol, 2017, 30: 414-423. http://pdfs.semanticscholar.org/6e51/c38abf8880f64de3fe77596c8066d4571106.pdf
    [28]
    Eun CS, Kim BK, Han DS, et al. Differences in gastric mucosal microbiota profiling in patients with chronic gastritis, intestinal metaplasia, and gastric cancer using pyrosequenc-ing methods [J]. Helicobacter, 2014, 19: 407-416. DOI: 10.1111/hel.12145
    [29]
    Pimentel-Nunes P, Barros A, Pita I, et al. Gastric microbiome profile throughout gastric carcinogenesis: beyond helicobacter[J]. Scand J Gastroenterol, 2021, 56: 708-716. DOI: 10.1080/00365521.2021.1902560
    [30]
    Abranches J, Zeng L, Kajfasz JK, et al. Biology of oral streptococci[J]. Microbiology spectrum, 2018, 6: 10.1128/microbiolspec. GPP3-0042-2018. DOI: 10.1128/microbiolspec.GPP3-0042-2018
    [31]
    Zhou CB, Pan SY, Jin P, et al. Fecal signatures of Streptococcus anginosus and Streptococcus constellatus for noninvasive screening and early warning of gastric cancer[J]. Gastroenterology, 2022, 162: 1933-1947. e18. DOI: 10.1053/j.gastro.2022.02.015
    [32]
    Ford AC, Yuan Y, Moayyedi P. eradication therapy to prevent gastric cancer: systematic review and meta-analysis[J]. Gut, 2020, 69: 2113-2121. DOI: 10.1136/gutjnl-2020-320839
    [33]
    姬瑞. 武威自然人群队列胃癌筛查及相关危险因素分析[D]. 兰州: 兰州大学, 2018.
    [34]
    Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis[J]. Gut, 2018, 67: 1024-1032. DOI: 10.1136/gutjnl-2017-314281
    [35]
    Bergers G, Fendt SM. The metabolism of cancer cells during metastasis[J]. Nat Rev Cancer, 2021, 21: 162-180. DOI: 10.1038/s41568-020-00320-2
    [36]
    Eyvazi S, Vostakolaei MA, Dilmaghani A, et al. The oncogenic roles of bacterial infections in development of cancer[J]. Microb Pathog, 2020, 141: 104019. DOI: 10.1016/j.micpath.2020.104019
    [37]
    Hsieh YY, Tung SY, Pan HY, et al. Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan[J]. Sci Rep, 2018, 8: 158. DOI: 10.1038/s41598-017-18596-0
    [38]
    Liou JM, Lee YC, El-Omar EM, et al. Efficacy and Long-Term Safety of H. pylori Eradication for Gastric Cancer Prevention[J]. Cancers (Basel), 2019, 11: 593. DOI: 10.3390/cancers11050593
    [39]
    Wang X, Liu H, Ni Y, et al. Lactate shuttle: from substance exchange to regulatory mechanism[J]. Hum Cell, 2022, 35: 1-14.
    [40]
    Huang XM, Liu XS, Lin XK, et al. Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer[J]. Cancer Sci, 2014, 105: 150-158. DOI: 10.1111/cas.12327
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