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Volume 12 Issue 2
May  2021
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GAO Yang, SUN Zhao, BAI Chun-mei. The Role of Pyruvate Kinase M2 in Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 227-231. DOI: 10.12290/xhyxzz.20190274
Citation: GAO Yang, SUN Zhao, BAI Chun-mei. The Role of Pyruvate Kinase M2 in Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 227-231. DOI: 10.12290/xhyxzz.20190274
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The Role of Pyruvate Kinase M2 in Gastric Cancer

  • Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    SUN Zhao   Tel: 86-10-69158754, E-mail: jessiesz@126.com

  • Received Date: December 08, 2019
  • Accepted Date: August 19, 2020
  • Available Online: December 29, 2020
  • Issue Publish Date: May 29, 2021
    Graphical Abstract
    • Abstract
  • Gastric cancer is one of the most common malignant neoplasms with high morbidity and mortality. Pyruvate kinase M2 (PKM2) is one of the key rate-limiting enzymes in glycolysis. The expression of PKM2 is significantly increased in a variety of tumors. It is currently considered that PKM2 is related to the development of tumors. PKM2 may promote the development of gastric cancer through the regulation of glycolysis, activation of PI3K/Akt/mTOR and inhibition of apoptosis of tumor cells. Literature will be briefly summarized in this review.
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    • References (40)
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