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Volume 15 Issue 1
Jan.  2024
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SUN Zhencan, ZHOU Jukun, XU Yunpeng, WANG Jun, ZHENG Ya, WANG Yuping, JI Rui. Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 160-165. DOI: 10.12290/xhyxzz.2023-0341
Citation: SUN Zhencan, ZHOU Jukun, XU Yunpeng, WANG Jun, ZHENG Ya, WANG Yuping, JI Rui. Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 160-165. DOI: 10.12290/xhyxzz.2023-0341
shu

Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori

  • 1.

    The First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, China

  • 2.

    Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China

  • 3.

    Digestive Endoscopy Center, the First Hospital of Lanzhou University, Lanzhou 730000, China

  • 4.

    Gansu Province Clinical Research Center for Digestive Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China

Funds: 

Lanzhou Talent Innovation and Entrepreneurship Project 2019-RC-33

Directional Exploration Project of Medical Department of Lanzhou University lzuyxcx-2022-184

More Information
  • Corresponding author:

    JI Rui, E-mail: jir@lzu.edu.cn

  • Received Date: July 22, 2023
  • Accepted Date: September 07, 2023
  • Issue Publish Date: January 29, 2024
    Graphical Abstract
    • Abstract
  • Helicobacter pylori (Hp) is a unipolar, microaerobic, multiflagellar, spiral-shaped Gram-negative bacterium that survives and colonizes human gastric mucosa. As a classⅠcarcinogen associated with gastric cancer, long-term stimulation of gastric mucosa by Hp can cause atrophic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It has been reported that Hp can cause epithelial-mesenchymal transition (EMT) in gastric epithelial cells, thereby inducing gastric cancer. We review the mechanism of Hp-induced EMT in gastric epithelial cells, in order to provide new insights for early diagnosis and targeted therapy of gastric cancer.
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    • References (41)
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