Xiao-na JIN, Nai-xin LIANG, Meng-zhao WANG, Bing JIA, Xi-min SHI, Shan-qing LI, Fang LI, Fan WANG, Zhao-hui ZHU. Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(5): 327-333. DOI: 10.3969/j.issn.1674-9081.2016.05.002
Citation: Xiao-na JIN, Nai-xin LIANG, Meng-zhao WANG, Bing JIA, Xi-min SHI, Shan-qing LI, Fang LI, Fan WANG, Zhao-hui ZHU. Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(5): 327-333. DOI: 10.3969/j.issn.1674-9081.2016.05.002

Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer

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  • Corresponding author:

    WANG Fan Tel: 010-82802871, E-mail:wangfan@bjmu.edu.cn

    ZHU Zhao-hui Tel: 010-69154196, E-mail:zhuzhh@pumch.cn

  • Received Date: July 30, 2016
  • Issue Publish Date: September 29, 2016
  •   Objective  To prospectively evaluate the value of integrin αvβ3 receptor imaging approach basedon single photon emission computed tomography/computed tomography (SPECT/CT), using 99mTc-3PRGD2 as the tracer, in diagnosis and staging of non-small cell lung cancer (NSCLC) compared with 18F-FDG positron emisson tomography/computed tomography(PET/CT).
      Methods  From February 2011 to December 2012, 65 patients with suspicious lung lesions were recruited with informed consent in Peking Union Medical College Hospital, including 41 males and 24 females, with a mean age of (60±11) years. The patients underwent both 99mTc-3PRGD2 SPECT/CT and 18F-FDG PET/CT within one week. After pathological diagnosis, all the patients were followed up until death or for at least two years. Receiver operating characteristic (ROC) curve, Z test, and Chi-square test were used to compare the diagnostic performance of the two imaging methods in assessing lung lesions and mediastinal lymph nodes.
      Results  Sixty-five lung lesions in 53 patients were pathologically diagnosed as NSCLC, and 14 lung lesions in 12 patients were proved as benign. Based on the American Joint Committee on Cancer/Union for International Cancer Control(AJCC-UICC) standard, 248 regions of lymph nodes had metastasis and 56 were negative regions. 99mTc-3PRGD2 SPECT/CT was found to have higher specificity compared with 18F-FDG PET/CT in the per-region diagnosis of lymph node metastasis (94.6% vs. 75.0%, P=0.008), whereas the sensitivity of the two methods showed no statistically significant difference (88.3% vs. 90.7%, P=0.557). There was no significant difference between the two methods in diagnostic performance for lung lesion (Z=0.82, P=0.410).
      Conclusion  99mTc-3PRGD2 SPECT/CT shows high specificity in the diagnosis of lymph node metastasis from NSCLC, which may complement 18F-FDG PET/CT in diagnosis and benefit surgical decision-making for patients with lung cancer.
  • [1]
    Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61:69-90.
    [2]
    Giaccone G. 18Fluorodeoxyglucose positron emission tomography, a standard diagnostic tool in lung cancer[J]. J Natl Cancer Inst, 2007, 99:1741-1743. DOI: 10.1093/jnci/djm245
    [3]
    Fischer B, Lassen U, Mortensen J, et al. Preoperative staging of lung cancer with combined PET-CT[J]. N Engl J Med, 2009, 361:32-39. DOI: 10.1056/NEJMoa0900043
    [4]
    Vansteenkiste J, Fischer BM, Dooms C, et al. Positron-emission tomography in prognostic and therapeutic assessment of lung cancer:systematic review[J]. Lancet Oncol, 2004, 5:531-540. DOI: 10.1016/S1470-2045(04)01564-5
    [5]
    Jia B, Liu Z, Zhu Z, et al. Blood clearance kinetics, biodistribution, and radiation dosimetry of a kit-formulated integrin αvβ3-selective radiotracer 99mTc-3PRGD2 in non-human primates[J]. Mol Imaging Biol, 2011, 13:730-736. DOI: 10.1007/s11307-010-0385-y
    [6]
    Zhu Z, Miao W, Li Q, et al. 99mTc-3PRGD2 for integrin receptor imaging of lung cancer:a multicenter study[J]. J Nucl Med, 2012, 53:716-722. DOI: 10.2967/jnumed.111.098988
    [7]
    Plow EF, Haas TA, Zhang L, et al. Ligand binding to integrins[J]. J Biol Chem, 2000, 275:21785-21788. DOI: 10.1074/jbc.R000003200
    [8]
    Haubner R, Weber WA, Beer AJ, et al. Noninvasive visualization of the activated αβ3 integrin in cancer patients by positron emission tomography and[18F]Galacto-RGD[J]. PLOS Med, 2005, 2:244-252. DOI: 10.1371/journal.pmed.0020244
    [9]
    Mittra ES, Goris ML, Iagaru AH, et al. Pilot pharmacokine-tic and dosimetric studies of (18)F-FPPRGD2:a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels[J]. Radiology, 2011, 260:182-191. DOI: 10.1148/radiol.11101139
    [10]
    Iagaru A, Mosci C, Shen B, et al. (18)F-FPPRGD2 PET/CT:pilot phase evaluation of breast cancer patients[J]. Radiology, 2014, 273:549-559. DOI: 10.1148/radiol.14140028
    [11]
    McParland BJ, Miller MP, Spinks TJ, et al. The biodistribution and radiation dosimetry of the Arg-Gly-Asp peptide 18F-AH111585 in healthy volunteers[J]. J Nucl Med, 2008, 49:1664-1667. DOI: 10.2967/jnumed.108.052126
    [12]
    Doss M, Kolb HC, Zhang JJ, et al. Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans[J]. J Nucl Med, 2012, 53:787-795. DOI: 10.2967/jnumed.111.088955
    [13]
    Wan W, Guo N, Pan D, et al. First experience of 18F-alfatide in lung cancer patients using a new lyophilized kit for rapid radiofluorination[J]. J Nucl Med, 2013, 54:691-698. DOI: 10.2967/jnumed.112.113563
    [14]
    Bach-Gansmo T, Danielsson R, Saracco A, et al. Integrin receptor imaging of breast cancer:a proof-of-concept study to evaluate 99mTc-NC100692[J]. J Nucl Med, 2006, 47:1434-1439.
    [15]
    Shi J, Wang L, Kim YS, et al. Improving tumor uptake and excretion kinetics of 99mTc-labeled cyclic arginine-glycine-aspartic (RGD) dimers with triglycine linkers[J]. J Med Chem, 2008, 51:7980-7990. DOI: 10.1021/jm801134k
    [16]
    Liu Z, Jia B, Shi J, et al. Tumor uptake of the RGD dimeric probe 99mTc-G3-2P4-RGD2 is correlated with integrin αvβ3 expressed on both tumor cells and neovasculature[J]. Bioconjug Chem, 2010, 21:548-555. DOI: 10.1021/bc900547d
    [17]
    Wolfenson H, Iskratsch T, Sheetz MP. Early events in cell spreading as a model for quantitative analysis of biomechanical events[J]. Biophys J, 2014, 107:2508-2514. DOI: 10.1016/j.bpj.2014.10.041
    [18]
    van den Hoogen C, van der Horst G, Cheung H, et al. Integrin αv expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer[J]. Am J Pathol, 2011, 179:2559-2568. DOI: 10.1016/j.ajpath.2011.07.011
    [19]
    Jin X, Meng Y, Zhu Z, et al. Elevated 99mTc-3PRGD2 activity in benign metastasizing leiomyoma[J]. Clin Nucl Med, 2013, 38:117-119. DOI: 10.1097/RLU.0b013e318279f14d
    [20]
    Deppen S, Putnam JB Jr, Andrade G, et al. Accuracy of FDG-PET to diagnose lung cancer in a region of endemic granulomatous disease[J]. Ann Thorac Surg, 2011, 92:428-433. DOI: 10.1016/j.athoracsur.2011.02.052
    [21]
    Miller JC, Pien HH, Sahani D, et al. Imaging angiogenesis:applications and potential for drug development[J]. J Natl Cancer Inst, 2005, 97:172-187. DOI: 10.1093/jnci/dji023
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