Volume 7 Issue 5
Sep.  2016
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Xiao-na JIN, Nai-xin LIANG, Meng-zhao WANG, Bing JIA, Xi-min SHI, Shan-qing LI, Fang LI, Fan WANG, Zhao-hui ZHU. Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(5): 327-333. doi: 10.3969/j.issn.1674-9081.2016.05.002
Citation: Xiao-na JIN, Nai-xin LIANG, Meng-zhao WANG, Bing JIA, Xi-min SHI, Shan-qing LI, Fang LI, Fan WANG, Zhao-hui ZHU. Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(5): 327-333. doi: 10.3969/j.issn.1674-9081.2016.05.002

Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer

doi: 10.3969/j.issn.1674-9081.2016.05.002
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  • Corresponding author: WANG Fan Tel: 010-82802871, E-mail:wangfan@bjmu.edu.cn; ZHU Zhao-hui Tel: 010-69154196, E-mail:zhuzhh@pumch.cn
  • Received Date: 2016-07-31
  • Publish Date: 2016-09-30
  •   Objective  To prospectively evaluate the value of integrin αvβ3 receptor imaging approach basedon single photon emission computed tomography/computed tomography (SPECT/CT), using 99mTc-3PRGD2 as the tracer, in diagnosis and staging of non-small cell lung cancer (NSCLC) compared with 18F-FDG positron emisson tomography/computed tomography(PET/CT).  Methods  From February 2011 to December 2012, 65 patients with suspicious lung lesions were recruited with informed consent in Peking Union Medical College Hospital, including 41 males and 24 females, with a mean age of (60±11) years. The patients underwent both 99mTc-3PRGD2 SPECT/CT and 18F-FDG PET/CT within one week. After pathological diagnosis, all the patients were followed up until death or for at least two years. Receiver operating characteristic (ROC) curve, Z test, and Chi-square test were used to compare the diagnostic performance of the two imaging methods in assessing lung lesions and mediastinal lymph nodes.  Results  Sixty-five lung lesions in 53 patients were pathologically diagnosed as NSCLC, and 14 lung lesions in 12 patients were proved as benign. Based on the American Joint Committee on Cancer/Union for International Cancer Control(AJCC-UICC) standard, 248 regions of lymph nodes had metastasis and 56 were negative regions. 99mTc-3PRGD2 SPECT/CT was found to have higher specificity compared with 18F-FDG PET/CT in the per-region diagnosis of lymph node metastasis (94.6% vs. 75.0%, P=0.008), whereas the sensitivity of the two methods showed no statistically significant difference (88.3% vs. 90.7%, P=0.557). There was no significant difference between the two methods in diagnostic performance for lung lesion (Z=0.82, P=0.410).  Conclusion  99mTc-3PRGD2 SPECT/CT shows high specificity in the diagnosis of lymph node metastasis from NSCLC, which may complement 18F-FDG PET/CT in diagnosis and benefit surgical decision-making for patients with lung cancer.
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