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Volume 12 Issue 1
Jan.  2021
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ZHANG Lu, ZHOU Wei, PENG Yan, ZHAN Wei-wei. Efficacy of Percutaneous Laser Ablation in the Treatment of Cervical Metastatic Lymph Nodes after the Surgery of Papillary Thyroid Carcinoma: A Prospective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 67-72. DOI: 10.12290/xhyxzz.20190238
Citation: ZHANG Lu, ZHOU Wei, PENG Yan, ZHAN Wei-wei. Efficacy of Percutaneous Laser Ablation in the Treatment of Cervical Metastatic Lymph Nodes after the Surgery of Papillary Thyroid Carcinoma: A Prospective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 67-72. DOI: 10.12290/xhyxzz.20190238
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Efficacy of Percutaneous Laser Ablation in the Treatment of Cervical Metastatic Lymph Nodes after the Surgery of Papillary Thyroid Carcinoma: A Prospective Cohort Study

  • Department of Ultrasound, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Funds: 

Capacity Building Project of Clinical Auxiliary Department of Shanghai Shenkang Hospital Development Center (Ultrasonic Medicine) SHDC22015006

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  • Corresponding author:

    ZHAN Wei-wei Tel: 86-21-64370045-362563, E-mail: shanghairuijin@126.com

  • Received Date: October 29, 2019
  • Accepted Date: April 23, 2020
  • Issue Publish Date: January 29, 2021
    Graphical Abstract
    • Abstract
  •   Objective  The aim of this study was to evaluate the therapeutic efficacy of ultrasound-guided percutaneous laser ablation (PLA) in the treatment of cervical metastatic lymph nodes (MLNs) after the surgery of papillary thyroid carcinoma (PTC).
      Methods  Clinical data of patients with recurrent PTC after surgery undergoing PLA treatment and regular follow-up from January 2014 to September 2016 were prospectively collected in Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Two-dimensional ultrasound was used to monitor the intraoperative process of PLA, and to evaluate the complications and lesion changes after ablation. Contrast-enhanced ultrasound(CEUS) was performed before treatment and at 1 h and 2-7 d after PLA to evaluate perfusion defects. All patients were followed up(As of May 2019), and the maximum diameter and volume of lesions after ablation were recorded during follow-up.
      Results  A total of 35 patients (46 cervical MLNs) meeting the inclusive and exclusive criteria were enrolled in this study. Preoperative CEUS showed that 20 MLNs were heterogeneously perfused (including 1 liquefied lymph node), while 26 MLNs were homogeneously perfused. During 2-7 d after PLA, CEUS showed that the boundary of the perfusion-defect area was clearer than that of 1 h after the operation, and the volume of the perfusion-defect area was significantly larger than that of 1 h after the operation[230.40(78.03, 361.17)mm3 vs. 130.62(43.06, 253.66)mm3, P < 0.05]. All patients tolerated well to PLA without neck hematoma, active bleeding, infection, tracheal esophageal injury, or other complications. The mean follow-up was (56.7±8.9)months, and there was no case of lymph node recurrence in situ. The maximum diameter [0.00(0.00, 0.00)mm vs. 7.35(5.70, 9.63)mm, P < 0.05] and the lesion volume [0.00(0.00, 0.00)mm3 vs. 95.59(32.82, 169.01)mm3, P < 0.05] at the last follow-up after ablation were significantly reduced compared with preoperation.
      Conclusions  PLA guided by ultrasound guidance may have a certain therapeutic effect on the neck MLNs after PTC surgery.
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    • References (27)
  • [1]
    Cooper DS, Doherty GM, Haugen BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer[J]. Thyroid, 2009, 19:1167-1214. DOI: 10.1089/thy.2009.0110
    [2]
    Samaan NA, Schultz PN, Hickey RC, et al. The results of various modalities of treatment of well differentiated thyroid carcinomas: a retrospective review of 1599 patients[J]. J Clin Endocrinol Metab, 1992, 75:714-720.
    [3]
    Takami H, Ikeda Y, Miyabe R, et al. Radiological and surgical management of thyroid neoplasms[J]. Biomed Pharmacother, 2004, 58:360-364. DOI: 10.1016/j.biopha.2004.05.005
    [4]
    Fontenot TE, Deniwar A, Bhatia P, et al. Percutaneous ethanol injection vs reoperation for locally recurrent papillary thyroid cancer: a systematic review and pooled analysis[J]. JAMA Otolaryngol Head Neck Surg, 2015, 141:512-518. DOI: 10.1001/jamaoto.2015.0596
    [5]
    Vannucchi G, Covelli D, Perrino M, et al. Ultrasound-guided percutaneous ethanol injection in papillary thyroid cancer metastatic lymph-nodes[J]. Endocrine, 2014, 47:648-651. DOI: 10.1007/s12020-014-0215-0
    [6]
    Mauri G, Cova L, Tondolo T, et al. Percutaneous laser ablation of metastatic lymph nodes in the neck from papillary thyroid carcinoma: preliminary results[J]. J Clin Endocrinol Metab, 2013, 98:E1203-E1207. DOI: 10.1210/jc.2013-1140
    [7]
    Papini E, Bizzarri G, Bianchini A, et al. Percutaneous ultrasound-guided laser ablation is effective for treating selected nodal metastases in papillary thyroid cancer[J]. J Clin Endocrinol Metab, 2013, 98:E92-E97. DOI: 10.1210/jc.2012-2991
    [8]
    Mauri G, Cova L, Ierace T, et al. Treatment of Metastatic Lymph Nodes in the Neck from Papillary Thyroid Carcinoma with Percutaneous Laser Ablation[J]. Cardiovasc Intervent Radiol, 2016, 39:1023-1030. DOI: 10.1007/s00270-016-1313-6
    [9]
    Valcavi R, Piana S, Bortolan GS, et al. Ultrasound-guided percutaneous laser ablation of papillary thyroid microcarcinoma: a feasibility study on three cases with pathological and immunohistochemical evaluation[J]. Thyroid, 2013, 23:1578-1582. DOI: 10.1089/thy.2013.0279
    [10]
    Zhou W, Zhang L, Zhan W, et al. Percutaneous laser ablation for treatment of locally recurrent papillary thyroid carcinoma < 15 mm[J]. Clin Radiol, 2016, 71:1233-1239. DOI: 10.1016/j.crad.2016.07.010
    [11]
    Guang Y, Luo Y, Zhang Y, et al. Efficacy and safety of percutaneous ultrasound guided radiofrequency ablation for treating cervical metastatic lymph nodes from papillary thyroid carcinoma[J]. J Cancer Res Clin Oncol, 2017, 143:1555-1562. DOI: 10.1007/s00432-017-2386-6
    [12]
    Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto's thyroiditis[J]. Tumour Biol, 2016, 37:8037-8045. DOI: 10.1007/s13277-015-4706-2
    [13]
    Kim DW. Sonography-Guided Ethanol Ablation of a Remnant Solid Component after Radio-Frequency Ablation of Benign Solid Thyroid Nodules: A Preliminary Study[J]. AJNR Am J Neuroradiol, 2012, 33:1139-1143. DOI: 10.3174/ajnr.A2904
    [14]
    Yue W, Chen L, Wang S, et al. Locoregional control of recurrent papillary thyroid carcinoma by ultrasound-guided percutaneous microwave ablation: A prospective study[J]. Int J hyperthermia, 2015, 31:403-408. DOI: 10.3109/02656736.2015.1014433
    [15]
    Feng B, Liang P, Cheng Z, et al. Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies[J]. Eur J Endocrinol, 2012, 166:1031-1037. DOI: 10.1530/EJE-11-0966
    [16]
    张璐, 詹维伟, 周伟, 等.超声引导下经皮激光消融治疗甲状腺乳头状癌术后复发转移淋巴结[J].中国介入影像与治疗学, 2018, 15:461-463. https://www.cnki.com.cn/Article/CJFDTOTAL-JRYX201808005.htm

    Zhang L, Zhan WW, Zhou W, et al. Ultrasound-guided percutaneous laser ablation for treatment of post-operative cervical metastatic lymph nodes of recurrent papillary thyroid carcinoma[J]. Zhongguo Jie Ru Ying Xiang Yu Zhi Liao Xue, 2018, 15:461-463. https://www.cnki.com.cn/Article/CJFDTOTAL-JRYX201808005.htm
    [17]
    Du J, Li HL, Zhai B, et al. Radiofrequency ablation for hepatocellular carcinoma: utility of conventional ultrasound and contrast-enhanced ultrasound in guiding and assessing early therapeutic response and short-term follow-up results[J]. Ultrasound Med Biol, 2015, 41:2400-2411. DOI: 10.1016/j.ultrasmedbio.2015.05.004
    [18]
    Gao Y, Zheng DY, Cui Z, et al. Predictive value of quantitative contrast-enhanced ultrasound in hepatocellular carcinoma recurrence after ablation[J]. World J Gastroenterol, 2015, 21:10418-10426. DOI: 10.3748/wjg.v21.i36.10418
    [19]
    Mauri G, Porazzi E, Cova L, et al. Intraprocedural contrast-enhanced ultrasound (CEUS) in liver percutaneous radiofrequency ablation: clinical impact and health technology assessment[J]. Insights Imaging, 2014, 5:209-216. DOI: 10.1007/s13244-014-0315-7
    [20]
    Li X, Liang P, Yu J, et al. Role of contrast-enhanced ultrasound in evaluating the efficiency of ultrasound guided percutaneous microwave ablation in patients with renal cell carcinoma[J]. Radiol Oncol, 2013, 47:398-404. DOI: 10.2478/raon-2013-0038
    [21]
    Xu L, Rong Y, Wang W, et al. Percutaneous radiofrequency ablation with contrast-enhanced ultrasonography for solitary and sporadic renal cell carcinoma in patients with autosomal dominant polycystic kidney disease[J]. World J Surg Oncol, 2016, 14:193. DOI: 10.1186/s12957-016-0916-3
    [22]
    Wu R, Xu FH, Yao MH, et al. Contrast-enhanced ultrasonography follow-up after radiofrequency ablation in normal rabbit kidney[J]. Arch Med Sci, 2013, 9:608-613.
    [23]
    Zhou W, Jiang S, Zhan W, et al. Ultrasound-guided percutaneous laser ablation of unifocal T1N0M0 papillary thyroid microcarcinoma: Preliminary results[J]. Eur Radiol, 2017, 27:2934-2940. DOI: 10.1007/s00330-016-4610-1
    [24]
    Wang L, Ge M, Xu D, et al. Ultrasonography-guided percutaneous radiofrequency ablation for cervical lymph node metastasis from thyroid carcinoma[J]. J Cancer Res Ther, 2014, 10 Suppl:C144-C149.
    [25]
    Ma S, Zhou P. Detection of the Single-Session Complete Ablation Rate by Contrast-Enhanced Ultrasound during Ultrasound-Guided Laser Ablation for Benign Thyroid Nodules: A Prospective Study[J]. Biomed Res Int, 2016, 2016: 9565364. doi: 10.1155/2016/9565364.
    [26]
    Sumagin R, Prizant H, Lomakina E, et al. LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ[J]. J Immunol, 2010, 185:7057-7066. DOI: 10.4049/jimmunol.1001638
    [27]
    Zhou L, Keane D, Reed G, et al. Thromboembolic complica-tions of cardiac radiofrequency catheter ablation: a review of the reported incidence, pathogenesis and current research directions[J]. J Cardiovasc Electrophysiol, 1999, 10:611-620. DOI: 10.1111/j.1540-8167.1999.tb00719.x
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