Volume 14 Issue 4
Jul.  2023
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ZHU Shikun, ZHANG Shu, LUO Yaping. SPECT/CT in Localization of Sentinel Lymph Node of Skin Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 795-801. doi: 10.12290/xhyxzz.2023-0170
Citation: ZHU Shikun, ZHANG Shu, LUO Yaping. SPECT/CT in Localization of Sentinel Lymph Node of Skin Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 795-801. doi: 10.12290/xhyxzz.2023-0170

SPECT/CT in Localization of Sentinel Lymph Node of Skin Tumors

doi: 10.12290/xhyxzz.2023-0170
Funds:

National High Level Hospital Clinical Research Funding 2022-PUMCH-A-046

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-070

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  • Corresponding author: LUO Yaping, E-mail: luoyaping@live.com
  • Received Date: 2023-04-03
  • Accepted Date: 2023-06-27
  • Publish Date: 2023-07-30
  •   Objective  Sentinel node lymphoscintigraphy and biopsy is an essential procedure in theranostics of skin tumors.The aim of this study is to determine the role of SPECT/CT in localization of sentinel lymph node of skin tumors.  Methods  This study retrospectively reviewed the sentinel node lymphoscintigraphy and biopsy data in patients with skin tumors diagnosed in Peking Union Medical College Hospital from April 2019 to February 2023, and analyzed the role of SPECT/CT in sentinel lymphoscintigraphy.  Results  Thirty-seven patients were retrospectively enrolled.The primary skin tumor included melanoma (32 patients), squamous cell carcinoma (3 patients), and basal cell carcinoma (2 patients).The sentinel nodes localized in inguinal (23 patients), popliteal (2 patients), axilla (8 patients), trochlea (2 patients), and parotid/periauricular regions (2 patients).Sentinel lymph nodes were localized by SPECT/CT in 36 cases (one patient only underwent planar dynamic imaging).SPECT/CT detected multiple focus in the lymphatic drainage in 16 patients, and in 13 patients they were confirmed to be local retention of the tracer in the lymphatic duct instead of the sentinel lymph node, suggesting false positive uptake.Thirty-four patients underwent sentinel node biopsy 1-4 h after localization, and localization of the sentinel node was consistent with preoperative sentinel node lymphoscintigraphy.Sentinel node biopsy found nodal metastasis in 6 patients (all of them had melanoma in the foot or lower limb).  Conclusions  Sentinel node lymphoscintigraphy is an important step for localization before sentinel node biopsy.SPECT/CT can help improve the accuracy of localizing sentinel lymph node.
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  • [1] Khan K, Mykula R, Kerstein R, et al. A 5-year follow-up study of 633 cutaneous SCC excisions: Rates of local recurrence and lymph node metastasis[J]. J Plast Reconstr Aesthet Surg, 2018, 71: 1153-1158. doi:  10.1016/j.bjps.2018.03.019
    [2] Genders RE, Osinga JAJ, Tromp EE, et al. Metastasis Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Immunocompetent Patients[J]. Acta Derm Venereol, 2018, 98: 551-555. doi:  10.2340/00015555-2901
    [3] Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012[J]. J Am Acad Dermatol, 2013, 68: 957-966. doi:  10.1016/j.jaad.2012.11.037
    [4] Rodrigues LK, Leong SP, Ljung BM, et al. Fine needle aspiration in the diagnosis of metastatic melanoma[J]. J Am Acad Dermatol, 2000, 42: 735-740. doi:  10.1067/mjd.2000.103812
    [5] Voit CA, van Akkooi AC, Schäfer-Hesterberg G, et al. Rotterdam Criteria for sentinel node (SN) tumor burden and the accuracy of ultrasound (US)-guided fine-needle aspiration cytology (FNAC): can US-guided FNAC replace SN staging in patients with melanoma?[J]. J Clin Oncol, 2009, 27: 4994-5000. doi:  10.1200/JCO.2008.19.0033
    [6] Zaknun JJ, Giammarile F, Olmos RA, et al. Changing paradigms in radioguided surgery and intraoperative imaging: the GOSTT concept[J]. Eur J Nucl Med Mol Imaging, 2012, 39: 1-3.
    [7] Alazraki N, Glass EC, Castronovo F, et al. Procedure guideline for lymphoscintigraphy and the use of intraoperative gamma probe for sentinel lymph node localization in melanoma of intermediate thickness 1.0[J]. J Nucl Med, 2002, 43: 1414-1418.
    [8] Benke M, Wocial K, Lewandowska W, et al. Value of planar lymphoscintigraphy (PL) versus SPECT/CT in evaluation of sentinel lymph node in trunk melanoma - one center, large series retrospective study[J]. Nucl Med Rev Cent East Eur, 2018, 21: 79-84. doi:  10.5603/NMR.a2018.0022
    [9] Zhang S, Zhu S, Hua S, et al. The importance of SPECT/CT in preoperative localization of sentinel lymph nodes in 2 patients with acral melanoma in the foot[J]. Clin Nucl Med, 2022, 47: e32-e33. doi:  10.1097/RLU.0000000000003700
    [10] McGregor A, Kim S, Norwich-Cavanaugh A, et al. Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma[J]. Ann Plast Surg, 2019, 82: 192-194. doi:  10.1097/SAP.0000000000001895
    [11] Quartuccio N, Garau LM, Arnone A, et al. Comparison of (99m)Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis[J]. J Clin Med, 2020, 9: 1680. doi:  10.3390/jcm9061680
    [12] Valdés Olmos RA, Rietbergen DDD, Rubello D, et al. Sentinel Node Imaging and Radioguided Surgery in the Era of SPECT/CT and PET/CT: Toward New Interventional Nuclear Medicine Strategies[J]. Clin Nucl Med, 2020, 45: 771-777. doi:  10.1097/RLU.0000000000003206
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