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LI Jinpeng, GUO Jie, LIU Tao, WEI Xiaotao, SONG Yuan, WANG Weiwei, HE Zhijun. Research Progress on the Main Mechanism Affecting Flap Survival[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0253
Citation: LI Jinpeng, GUO Jie, LIU Tao, WEI Xiaotao, SONG Yuan, WANG Weiwei, HE Zhijun. Research Progress on the Main Mechanism Affecting Flap Survival[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0253
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Research Progress on the Main Mechanism Affecting Flap Survival

  • 1 Foot and Ankle Orthopedics, Gansu Provincial Hospital of TCM, Lanzhou 730000, China;

  • 2 Nursing Department, Gansu Provincial Hospital of TCM, Lanzhou 730000, China;

  • 3 Second Department of Hand Surgery, Gansu Provincial Hospital of TCM, Lanzhou 730000, China;

  • 4 College of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China

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  • Received Date: April 18, 2024
  • Accepted Date: June 13, 2024
  • Available Online: November 22, 2024
    Graphical Abstract
    • Abstract
  • Flap surgery is a complex surgical procedure that has become one of the effective methods for the treatment of many diseases and traumas. Flap survival is closely related to a variety of factors including cellular autophagy, oxidative stress, inflammatory response, mesenchymal stem cell function, and vascular regeneration. Cellular autophagy maintains intracellular homeostasis and plays a key role in reducing oxidative stress and inflammation and promoting injury repair. Excessive oxidative stress and inflammatory responses pose a threat to flaps, affecting their survival and successful transplantation. Endothelial cells are involved in vascular regeneration through proliferation, migration, and production of angiogenic factors, whereas vascular endothelial growth factor directly promotes blood vessel formation and maintains endothelial cell function. MSCs play an important role in promoting flap survival and tissue repair through their unique biological properties and multiple mechanisms of action. The multiple roles played by cellular autophagy, oxidative stress, inflammatory response, MSC function, and vascular regeneration in influencing postoperative flap survival are hereby elaborated. The aim is to provide a basis for the clinical application of regulating the above factors to improve postoperative flap survival, and to improve the success rate of flap surgery, reduce complications, and bring more hope for the recovery and quality of life of patients.
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    • References (56)
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