| Citation: |
YANG Xinyu, LI Yanjie, QIN Hewei, LIU Dandan, ZHAO Nannan, JIANG Jingjing. The Role of SIRT1 in Vascular Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(5): 1124-1130. DOI: 10.12290/xhyxzz.2024-0062
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Vascular cognitive impairment (VCI) denotes a wide range of cognitive deficiencies resulting from cerebrovascular risk factors and cerebrovascular diseases. Sirtuin 1 (SIRT1), as a deacetylase, can mediate the deacetylation of histones and non-histone proteins. It is involved in regulating multiple pathophysiological processes of VCI, including neuroinflammation reduction, oxidative stress inhibition, cell apoptosis decrease, and blood-brain barrier protection, serving as a target for VCI treatment. This paper summarizes SIRT1 and the molecular mechanisms of targeting SIRT1 in order to provide a reference for the clinical treatment of VCI.
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