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Volume 14 Issue 6
Nov.  2023
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ZHAO Qin, ZHANG Jinjin, CHEN Lili, XING Yanchao. Research Progress of PDGF Promoting Wound Repair[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1289-1295. DOI: 10.12290/xhyxzz.2023-0223
Citation: ZHAO Qin, ZHANG Jinjin, CHEN Lili, XING Yanchao. Research Progress of PDGF Promoting Wound Repair[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1289-1295. DOI: 10.12290/xhyxzz.2023-0223
shu

Research Progress of PDGF Promoting Wound Repair

  • 1.

    School of Postgraduates, Xinjiang Medical University, Urumqi 830054, China

  • 2.

    Department of Transfusion Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, China

Funds: 

Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01C342

More Information
  • Corresponding author:

    XING Yanchao, E-mail: xingyanchao@aliyun.com

  • Received Date: May 03, 2023
  • Accepted Date: July 17, 2023
  • Issue Publish Date: November 29, 2023
    Graphical Abstract
    • Abstract
  • Platelet-derived growth factor (PDGF), a multi-potent cytokine, has caught attention in the field of wound repair. The PDGF ability to initiate cell proliferation, migration, secretion and promote angiogenesis can be beneficial for wound healing. Platelet-rich plasma and recombinant human PDGF that contain high concentrations of PDGF have been used for decades in wound repair. However, their short shelf life, limited allogenic use, low bioavailability, and many side effects make them unable to meet clinical needs. Optimized platelet-rich fibrin and concentrated growth factor have higher concentrations of PDGF and better wound repair ability. Platelet lysate, with the ability to significantly extend the preservation period and reduce the risk of allogeneic use, has become the development direction for platelet wound repair. The high-energy delivery system based on bioengineering technology can significantly improve the local resident rate and prolong the action time of PDGF. A variety of transformed PDGF capable of inducing sustained tonic signals can be created through the modification of PDGF structure and addition of active domains. Functional controllable PDGF simulation peptides can be generated by integrating the active domains and a variety of efficient PDGF gene delivery strategies can be derived, thus providing more potential options to solve the problem of wound repair. The focus of this article, is on reviewing the physiological and applied.
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    • References (44)
  • [1]
    Tang X, Hao M, Chang C, et al. Wound Healing Driver Gene and Therapeutic Development: Political and Scientific Hurdles[J]. Adv Wound Care (New Rochelle), 2021, 10: 415-435. DOI: 10.1089/wound.2019.1143
    [2]
    Oliveira A, Simões S, Ascenso A, et al. Therapeutic advances in wound healing[J]. J Dermatolog Treat, 2022, 33: 2-22. DOI: 10.1080/09546634.2020.1730296
    [3]
    Rahman MM, Garcia N, Loh YS, et al. A platelet-derived hydrogel improves neovascularisation in full thickness wounds[J]. Acta Biomater, 2021, 136: 199-209. DOI: 10.1016/j.actbio.2021.09.043
    [4]
    Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes[J]. Open Biol, 2020, 10: 200223. DOI: 10.1098/rsob.200223
    [5]
    Yao L, Rathnakar BH, Kwon HR, et al. Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing[J]. Cell Rep, 2022, 40: 111192. DOI: 10.1016/j.celrep.2022.111192
    [6]
    Fernández-Simón E, Suárez-Calvet X, Carrasco-Rozas A, et al. RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells: implications for Duchenne muscular dystrophy[J]. J Cachexia Sarcopenia Muscle, 2022, 13: 1373-1384. DOI: 10.1002/jcsm.12923
    [7]
    Contreras O, Córdova-Casanova A, Brandan E. PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells[J]. Cell Signal, 2021, 84: 110036. DOI: 10.1016/j.cellsig.2021.110036
    [8]
    Su W, Liu G, Liu X, et al. Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development[J]. JCI Insight, 2020, 5: e135446. DOI: 10.1172/jci.insight.135446
    [9]
    Shang Y, Liu H, Peng R, et al. PDGF-mimicking supramolecular nanofibers for ionizing radiation-induced injury repair[J]. Chem Eng J, 2021, 410: 128309. DOI: 10.1016/j.cej.2020.128309
    [10]
    Chen Y, Jiang L, Lyu K, et al. A Promising Candidate in Tendon Healing Events-PDGF-BB[J]. Biomolecules, 2022, 12: 1518. DOI: 10.3390/biom12101518
    [11]
    Jian K, Yang C, Li T, et al. PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing[J]. J Nanobiotechnol, 2022, 20: 201. DOI: 10.1186/s12951-022-01390-0
    [12]
    曾淑红, 易成刚. 血小板浓缩提取物促进组织修复的研究进展[J]. 中国美容整形外科杂志, 2021, 32: 768-771. https://www.cnki.com.cn/Article/CJFDTOTAL-SMZW202112021.htm
    [13]
    Mochizuki M, Güç E, Park AJ, et al. Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing[J]. Nat Biomed Eng, 2020, 4: 463-475.
    [14]
    Assoian RK, Grotendorst GR, Miller DM, et al. Cellular transformation by coordinated action of three peptide growth factors from human platelets[J]. Nature, 1984, 309: 804-806. DOI: 10.1038/309804a0
    [15]
    Shirbhate U, Bajaj P. Third-Generation Platelet Concent-rates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration[J]. Cureus, 2022, 14: e28072.
    [16]
    Heililahong H, Jin P, Lei H, et al. Whole transcriptome analysis of platelet concentrates during storage[J]. Blood Transfus, 2023, 21: 146-156.
    [17]
    Shashank B, Bhushan M. Injectable Platelet-Rich Fibrin (PRF): The newest biomaterial and its use in various dermatological conditions in our practice: A case series[J]. J Cosmet Dermatol, 2021, 20: 1421-1426. DOI: 10.1111/jocd.13742
    [18]
    Choukroun J, Adda F, Schoeffler C, et al. Une opportunite' en paro-implantologie: le PRF[J]. Implantodontie, 2001, 42: 55-62.
    [19]
    Tunali M, Özdemir H, Küçükodaci Z, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin[J]. Biomed Res Int, 2014, 2014: 209548.
    [20]
    Corigliano M, Sacco L, Baldoni E. CGF-una proposta terapeutica per la medicina rigenerativa[J]. Odontoiatria, 2010, 1: 69-81.
    [21]
    Rodella LF, Favero G, Boninsegna R, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction[J]. Microsc Res Tech, 2011, 74: 772-777. DOI: 10.1002/jemt.20968
    [22]
    Cecerska-Heryć E, Goszka M, Serwin N, et al. Applications of the regenerative capacity of platelets in modern medicine[J]. Cytokine Growth Factor Rev, 2022, 64: 84-94. DOI: 10.1016/j.cytogfr.2021.11.003
    [23]
    He M, Guo X, Li T, et al. Comparison of Allogeneic Platelet-rich Plasma With Autologous Platelet-rich Plasma for the Treatment of Diabetic Lower Extremity Ulcers[J]. Cell Transplant, 2020, 29: 963689720931428.
    [24]
    Zhao Q, Ma Y, Lu Y, et al. Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report[J]. Adv Skin Wound Care, 2019, 32: 550-552. DOI: 10.1097/01.ASW.0000604176.47082.60
    [25]
    Burnouf T, Goubran HA. Regenerative effect of expired platelet concentrates in human therapy: An update[J]. Transfus Apher Sci, 2022, 61: 103363. DOI: 10.1016/j.transci.2022.103363
    [26]
    Daikuara LY, Yue Z, Skropeta D, et al. In vitro characterisation of 3D printed platelet lysate-based bioink for potential application in skin tissue engineering[J]. Acta Biomater, 2021, 123: 286-297. DOI: 10.1016/j.actbio.2021.01.021
    [27]
    Guo X, Liu C, Zhang Y, et al. Effect of super activated platelet lysate on cell proliferation, repair and osteogenesis[J]. Biomed Mater Eng, 2023, 34: 95-109.
    [28]
    D'amico R, Malucelli C, Uccelli A, et al. Therapeutic arteriogenesis by factor-decorated fibrin matrices promotes wound healing in diabetic mice[J]. J Tissue Eng, 2022, 13: 20417314221119615.
    [29]
    Banerjee A, Koul V, Bhattacharyya J. Fabrication of In Situ Layered Hydrogel Scaffold for the Co-delivery of PGDF-BB/Chlorhexidine to Regulate Proinflammatory Cytokines, Growth Factors, and MMP-9 in a Diabetic Skin Defect Albino Rat Model[J]. Biomacromolecules, 2021, 22: 1885-1900. DOI: 10.1021/acs.biomac.0c01709
    [30]
    Park TY, Maeng SW, Jeon EY, et al. Adhesive protein-based angiogenesis-mimicking spatiotemporal sequential release of angiogenic factors for functional regenerative medicine[J]. Biomaterials, 2021, 272: 120774. DOI: 10.1016/j.biomaterials.2021.120774
    [31]
    Lee CH, Liu KS, Cheng CW, et al. Codelivery of Sustain-able Antimicrobial Agents and Platelet-Derived Growth Factor via Biodegradable Nanofibers for Repair of Diabetic Infectious Wounds[J]. ACS Infect Dis, 2020, 6: 2688-2697. DOI: 10.1021/acsinfecdis.0c00321
    [32]
    Ahmad T, Mcgrath S, Sirafim C, et al. Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles[J]. Biomater Sci, 2021, 9: 4278-4288. DOI: 10.1039/D0BM01277G
    [33]
    Joshi A, Kaur T, Joshi A, et al. Light-Mediated 3D Printing of Micro-Pyramid-Decorated Tailorable Wound Dressings with Endogenous Growth Factor Sequestration for Improved Wound Healing[J]. ACS Appl Mater Interfaces, 2023, 15: 327-337. DOI: 10.1021/acsami.2c16418
    [34]
    Wang P, Berry D, Moran A, et al. Controlled Growth Factor Release in 3D-Printed Hydrogels[J]. Adv Healthc Mater, 2020, 9: e1900977. DOI: 10.1002/adhm.201900977
    [35]
    Rousselle P, Braye F, Dayan G. Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies[J]. Adv Drug Deliv Rev, 2019, 146: 344-365. DOI: 10.1016/j.addr.2018.06.019
    [36]
    White MJV, Briquez PS, White DAV, et al. VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes[J]. NPJ Regen Med, 2021, 6: 76. DOI: 10.1038/s41536-021-00189-1
    [37]
    Shim A, Liu H, Focia PJ, et al. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex[J]. Proc Natl Acad Sci U S A, 2010, 107: 11307-11312. DOI: 10.1073/pnas.1000806107
    [38]
    Perez JJ. Designing Peptidomimetics[J]. Curr Top Med Chem, 2018, 18: 566-590. DOI: 10.2174/1568026618666180522075258
    [39]
    Kumar S, Henning-Knechtel A, Magzoub M, et al. Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function[J]. J Am Chem Soc, 2018, 140: 6562-6574. DOI: 10.1021/jacs.7b13401
    [40]
    Deptuła M, Karpowicz P, Wardowska A, et al. Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds[J]. Adv Wound Care (New Rochelle), 2020, 9: 657-675. DOI: 10.1089/wound.2019.1051
    [41]
    Paramasivam T, Maiti SK, Palakkara S, et al. Effect of PDGF-B Gene-Activated Acellular Matrix and Mesenchymal Stem Cell Transplantation on Full Thickness Skin Burn Wound in Rat Model[J]. Tissue Eng Regen Med, 2021, 18: 235-251. DOI: 10.1007/s13770-020-00302-3
    [42]
    Thapa RK, Margolis DJ, Kiick KL, et al. Enhanced wound healing via collagen-turnover-driven transfer of PDGF-BB gene in a murine wound model[J]. ACS Appl Bio Mater, 2020, 3: 3500-3517. DOI: 10.1021/acsabm.9b01147
    [43]
    Hu WW, Lin YT. Alginate/polycaprolactone composite fibers as multifunctional wound dressings[J]. Carbohydr Polym, 2022, 289: 119440. DOI: 10.1016/j.carbpol.2022.119440
    [44]
    Shi R, Lian W, Han S, et al. Nanosphere-mediated co-delivery of VEGF-A and PDGF-B genes for accelerating diabetic foot ulcers healing in rats[J]. Gene Ther, 2018, 25: 425-438. DOI: 10.1038/s41434-018-0027-6
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