邮件订阅 RSS

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

胸腺原发上皮肌上皮癌首例报告并文献复习

王湘,  邵亚娟,  孙桂彬,  周娜,  甄宏楠,  陈杰,  赵林,  白春梅

downloadPDF
文章导航 > 协和医学杂志  > 2022 > 优先出版
王湘, 邵亚娟, 孙桂彬, 周娜, 甄宏楠, 陈杰, 赵林, 白春梅. 胸腺原发上皮肌上皮癌首例报告并文献复习[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2022-0318
引用本文: 王湘, 邵亚娟, 孙桂彬, 周娜, 甄宏楠, 陈杰, 赵林, 白春梅. 胸腺原发上皮肌上皮癌首例报告并文献复习[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2022-0318
shu
WANG Xiang, SHAO Yajuan, SUN Guibin, ZHOU Na, ZHEN Hongnan, CHEN Jie, ZHAO Lin, BAI Chunmei. Primary Epithelial-Myoepithelial Carcinoma of Thymus: First Case Report and Literature Review[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2022-0318
Citation: WANG Xiang, SHAO Yajuan, SUN Guibin, ZHOU Na, ZHEN Hongnan, CHEN Jie, ZHAO Lin, BAI Chunmei. Primary Epithelial-Myoepithelial Carcinoma of Thymus: First Case Report and Literature Review[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2022-0318
shu

胸腺原发上皮肌上皮癌首例报告并文献复习

doi: 10.12290/xhyxzz.2022-0318

  • 1 中国医学科学院北京协和医院 肿瘤内科, 北京 100730;

  • 2 中国医学科学院北京协和医院 放疗科, 北京 100730;

  • 3 中国医学科学院北京协和医院 病理科, 北京 100730;

  • 4 北京市普仁医院肿瘤科, 北京 100062

详细信息
    通讯作者:

    赵林,E-mail:wz20010727@aliyun.com

  • 中图分类号: R736.3

Primary Epithelial-Myoepithelial Carcinoma of Thymus: First Case Report and Literature Review

  • 1 Department of Medical Oncology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;

  • 2 Department of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;

  • 3 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;

  • 4 Department of Medical Oncology, Beijing Puren Hospital, Beijing 100062, China

    摘要
  • 摘要: 目的 探讨上皮肌上皮癌的临床症状、影像学特征、病理组织学特征和治疗方法。 方法 回顾性分析北京协和医院肿瘤内科收治的1例胸腺原发上皮肌上皮癌患者临床资料，并进行文献复习。 结果 患者为中年男性，诊断为胸腺原发上皮肌上皮癌，经手术、化疗、放疗、分子靶向治疗等综合治疗后仍出现疾病进展，从手术确诊至死亡时间为22个月。 结论 胸腺原发上皮肌上皮癌极为罕见，临床表现不典型，诊断主要依靠病理组织学检查，目前首选手术治疗，多学科综合治疗有助于延长患者的生存期。
    Abstract: Objective To analyze the clinical, imaging and pathological features of patients with epithelial-myoepithelial carcinoma(EMC). Methods The data of a patient with primary EMC of the thymus in Peking Union Medical College Hospital was retrospectively analyzed, and the relevant literature was reviewed. Results The patient was a middle-aged male diagnosed with primary EMC of the thymus. Even though the patient received a comprehensive treatment such as surgery, chemotherapy, radiotherapy and molecular targeted therapy, he still experienced disease progression with a survival time of 22 months after surgery. Conclusion Primary EMC of the thymus is extremely rare and has atypical clinical manifestations. The diagnosis mainly depends on histopathological examination. Surgery is the major treatment and multidisciplinary treatment is very important to prolong the survival of EMC patients.
    • HTML全文
    • 参考文献(39)
  • [1] Donath K, Seifert G, Schmitz R. Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts[J]. Virchows Arch A Pathol Pathol Anat, 1972, 356:16-31.
    [2] Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma:a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract[J]. Am J Surg Pathol, 2007, 31:44-57.
    [3] Gore MR. Epithelial-myoepithelial carcinoma:a population-based survival analysis[J]. BMC Ear Nose Throat Disord, 2018, 18:15.
    [4] Charles R, Murray S, Gray E, et al. Pulmonary epithelial-myoepithelial carcinoma (P-EMC) with focal high grade transformation:Molecular and cytologic findings[J]. Diagn Cytopathol, 2022, 50:E156-E162.
    [5] 刘勇,桑新亭,高维生,等.肝脏原发上皮-肌上皮癌首例报告[J].中华外科杂志, 2006, 44:1477-1479.
    [6] Kakkar A, Jangra K, Kumar N, et al. Epithelial-myoepithelial carcinoma of the breast:A rare type of malignant adenomyoepithelioma[J]. Breast J, 2019, 25:1273-1275.
    [7] 叶珊,吴景,李晓洁,等.乳腺上皮-肌上皮癌合并非特殊型浸润性癌的临床病理分析[J].临床与实验病理学杂志, 2015, 31:1239-1242.
    [8] 隋秀莉,蔡丹杰,曹炎焱,等.18F-FDG PET/CT诊断纵隔上皮-肌上皮癌[J].中国临床案例成果数据库, 2022, 4:E00691.
    [9] 方文涛,傅剑华,沈毅,等.胸腺肿瘤的诊疗:基于中国胸腺肿瘤协作组多中心回顾性研究的共识[J].中国肺癌杂志, 2016, 19:414-417.
    [10] Vazquez A, Patel TD, D'Aguillo CM, et al. Epithelial-Myoepithelial Carcinoma of the Salivary Glands:An Analysis of 246 Cases[J]. Otolaryngol Head Neck Surg, 2015, 153:569-574.
    [11] Okuyama K, Michi Y, Kashima Y, et al. Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands:Case Series with Comprehensive Review[J]. Diagnostics (Basel), 2021, 11:2124.
    [12] Suto T, Kato H, Kawaguchi M, et al. MRI findings of epithelial-myoepithelial carcinoma of the parotid gland with radiologic-pathologic correlation[J]. Jpn J Radiol, 2022, 40:578-585.
    [13] 李帅,蒋慧,彭雯佳.涎腺上皮-肌上皮癌的影像与病理特征分析[J].中国医学计算机成像杂志, 2021, 27:214-219.
    [14] 张巧娜,刘汉东.上颌窦上皮-肌上皮癌的CT表现一例[J].国际放射医学核医学杂志, 2016, 40:237-238.
    [15] 刘瑛,陈学志,于皓.原发性肺上皮-肌上皮癌CT表现一例[J].中华放射学杂志, 2021, 55:209-210.
    [16] García JJ. Atlas of Salivary Gland Pathology[M]. Springer, 2019.
    [17] Nakaguro M, Tanigawa M, Hirai H, et al. The Diagnostic Utility of RAS Q61R Mutationspecific Immunohistochemistry in Epithelial-Myoepithelial Carcinoma[J]. Am J Surg Pathol, 2021, 45:885-894.
    [18] Chenevert J, Duvvuri U, Chiosea S, et al. DOG1:a novel marker of salivary acinar and intercalated duct differentiation[J]. Mod Pathol, 2012, 25:919-929.
    [19] Ohtomo R, Mori T, Shibata S, et al. SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors:a clue to the histogenesis for tumor diagnosis[J]. Mod Pathol, 2013, 26:1041-1050.
    [20] Roy P, Bullock MJ, Perez-Ordoñez B, et al. Epithelial-myoepithelial carcinoma with high grade transformation[J]. Am J Surg Pathol, 2010, 34:1258-1265.
    [21] Urano M, Nakaguro M, Yamamoto Y, et al. Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum[J]. Am J Surg Pathol, 2019, 43:984-994.
    [22] Chiosea SI, Miller M, Seethala RR. HRAS mutations in epithelial-myoepithelial carcinoma[J]. Head Neck Pathol, 2014, 8:146-150.
    [23] Rupp NJ, Brada M, Skalova A, et al. New Insights into Tumor Heterogeneity:A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation[J]. Head Neck Pathol, 2020, 14:554-558.
    [24] El Hallani S, Udager AM, Bell D, et al. Epithelial-Myoepithelial Carcinoma:Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases[J]. Am J Surg Pathol, 2018, 42:18-27.
    [25] Friedrich RE, Donath K. Epithelial-myoepithelial carcinoma of the parotid gland with multiple distant metastases:a case report[J]. J Oral Maxillofac Surg, 2000, 58:690-694.
    [26] Corio RL, Sciubba JJ, Brannon RB, et al. Epithelial-myoepithelial carcinoma of intercalated duct origin. A clinicopathologic and ultrastructural assessment of sixteen cases[J]. Oral Surg Oral Med Oral Pathol, 1982, 53:280-287.
    [27] Hamper K, Brügmann M, Koppermann R, et al. Epithelial-myoepithelial ductcarcinoma of salivary giands-a foilow-up andcytophotometric study of 21cases[J]. J Oral Pathol Med, 1989, 18:299-304.
    [28] Simpson RH, Clarke TJ, Sarsfield PT, et al. Epithelial-myoepithelial carcinoma of salivary glands[J]. J Clin Pathol, 1991, 44:419-423.
    [29] 倪松,朱一鸣,王健,等.头颈部上皮-肌上皮癌的诊治分析[J].中国耳鼻咽喉头颈外科, 2017, 22:563-565.
    [30] 蔡红伟,刘勇,许泽兵,等.鼻腔/副鼻窦上皮-肌上皮癌放射治疗1例并文献复习[J].医学理论与实践, 2020, 33:2356-2358.
    [31] 马欢,张立洁,张艳,等.气管上皮-肌上皮癌放疗治疗1例[J].临床肺科杂志, 2018, 23:1353-1355.
    [32] Puri T, Singh K, Sharma DN, et al. Epithelial-myoepithelial carcinoma of the base of tongue-Pathology and management[J]. Indian J Cancer, 2004, 41:138-140.
    [33] Peters P, Repanos C, Earnshaw J, et al. Epithelial-myoepithelial carcinoma of the tongue base-a case for the case-report and review of the literature[J]. Head Neck Oncol, 2010, 2:4.
    [34] Kim SH, Park SE, Bae HG, et al. Epithelial-myoepithelial carcinoma of the nasopharynx:A case report and review of the literature[J]. Oncol Lett, 2015, 10:927-930.
    [35] 张婉泽,闫文星,张础,等.放疗联合化疗治疗鼻咽部上皮-肌上皮癌一例[J].国际肿瘤学杂志, 2018, 45:510-512.
    [36] 李浩,伍国号,陈福进,等.涎腺上皮-肌上皮癌的病理特点及治疗[J].中华耳鼻咽喉头颈外科杂志, 2006, 41:281-283.
    [37] Pierard S, Gregoire V, Weynand B, et al. Epithelial-myoepithelial carcinoma of the submandibular gland with symptomatic lung metastases treated with chemotherapy[J]. Eur Arch Otorhinolaryngol, 2006, 263:1158-1160.
    [38] Yamazaki H, Ota Y, Aoki T, et al. Lung metastases of epithelial-myoepithelial carcinoma of the parotid gland successfully treated with chemotherapy:a case report[J]. J Oral Maxillofac Surg, 2013, 71:220-226.
    [39] National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology:Head and Neck Cancers[EB/OL].[2022-06-01]. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1437.
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3
  • HTML全文浏览量:  0
  • PDF下载量:  0
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-06-09
  • 录用日期:  2022-07-11
  • 网络出版日期:  2022-07-28

目录

    /

    返回文章
    返回
    友情链接: 国家卫生健康委员会 北京协和医院 中国医学科学院 学术不端检测系统 国际知识资源总库 中国知网 术语在线 中国全科医学
    地址：北京市东城区帅府园1号 北京协和医院老楼7号楼
    3层302室 《协和医学杂志》编辑部
    电话：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    期刊网站版权所有：《协和医学杂志》编辑部
    京ICP备 11002662

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计