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Volume 15 Issue 2
Mar.  2024
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2024  >  15(2): 251-257
HE Yumiao, LI Mohan, MA Chao, HUANG Yuguang. Development and Translation of Super Long-acting Analgesics[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 251-257. doi: 10.12290/xhyxzz.2023-0574
Citation: HE Yumiao, LI Mohan, MA Chao, HUANG Yuguang. Development and Translation of Super Long-acting Analgesics[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 251-257. doi: 10.12290/xhyxzz.2023-0574
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Development and Translation of Super Long-acting Analgesics

doi: 10.12290/xhyxzz.2023-0574
  • 1.

    Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Joint Laboratory of Anesthesia and Pain, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

Funds:

National High Level Hospital Clinical Research Funding 2022-PUMCH-C-067

More Information
  • Corresponding author: MA Chao, E-mail: machao@ibms.cams.cn; HUANG Yuguang, E-mail: garypumch@163.com
  • Received Date: 2023-11-29
  • Accepted Date: 2023-12-29
    • Available Online: 2024-02-20
  • Publish Date: 2024-03-30
    Abstract
  • Pain management, listed as the fifth vital sign, has gained increasing attention from clinicians. Conventional analgesics have limited duration, leading to intense monitor and frequent dosing during the early phase in order to prevent the progression of chronic pain. Thus, prolonging the duration of analgesics has become one focus of the pain research. Several strategies, such as adding adjuvants, producing derivatives, and applying extended-release carriers, make it possible for super long-acting analgesics to come into reality. This review briefly introduces the strategies and development of the super long-acting analgesics, including the successful translation and commercialization of the present products of super long-acting analgesics. It also summarizes the application and translation of extended-release drug carriers, providing invaluable reference for the future research on the field of super long-acting analgesics.
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