JI Heyu, CUI Xulei, HUANG Yuguang. Recent Advances of Digital Therapeutics in Treatment of Chronic Pain[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 1046-1052. DOI: 10.12290/xhyxzz.2023-0086
Citation: JI Heyu, CUI Xulei, HUANG Yuguang. Recent Advances of Digital Therapeutics in Treatment of Chronic Pain[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 1046-1052. DOI: 10.12290/xhyxzz.2023-0086

Recent Advances of Digital Therapeutics in Treatment of Chronic Pain

Funds: 

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-007

More Information
  • Corresponding author:

    CUI Xulei, E-mail: cuixulei10685@pumch.cn

  • Received Date: February 15, 2023
  • Accepted Date: April 12, 2023
  • Issue Publish Date: September 29, 2023
  • Chronic pain is characterized by a high incidence and persistent, challenging recovery. It not only significantly troubles patients but also poses substantial challenges for clinical treatment. Digital therapeutics (DTx), an emerging evidence-based therapeutic approach by software programs, provides individualized disease management strategies for patients through digital networks. DTx enhances treatment adherence and facilitates data collection, which can be used as a monotherapy or in combination with other therapies. This review aims to summarize the progress of DTx application in the diagnosis and treatment of chronic pain, with the goal of providing valuable insights for the clinical management of chronic pain.
  • [1]
    宋学军, 樊碧发, 万有, 等. 国际疼痛学会新版疼痛定义修订简析[J]. 中国疼痛医学杂志, 2020, 26: 641-644. https://www.cnki.com.cn/Article/CJFDTOTAL-ZTYZ202009003.htm
    [2]
    Davis KD, Moayedi M. Central mechanisms of pain revealed through functional and structural MRI[J]. J Neuroimmune Pharmacol, 2013, 8: 518-534. DOI: 10.1007/s11481-012-9386-8
    [3]
    Descalzi G, Ikegami D, Ushijima T, et al., Epigenetic mechanisms of chronic pain[J]. Trends Neurosci, 2015, 38: 237-246. DOI: 10.1016/j.tins.2015.02.001
    [4]
    Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances[J]. Lancet, 2021, 397: 2082-2097. DOI: 10.1016/S0140-6736(21)00393-7
    [5]
    Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)[J]. Pain, 2019, 160: 19-27. DOI: 10.1097/j.pain.0000000000001384
    [6]
    Zheng YJ, Zhang TJ, Yang XQ, et al. A survey of chronic pain in China[J]. Libyan J Med, 2020, 15: 1730550. DOI: 10.1080/19932820.2020.1730550
    [7]
    Hong JS, Wasden C, Han DH. Introduction of digital therapeutics[J]. Comput Methods Programs Biomed, 2021, 209: 106319. DOI: 10.1016/j.cmpb.2021.106319
    [8]
    徐宜蕙, 张一帆, 李杨, 等. 美国FDA批准的数字疗法产品临床试验设计研究[J]. 中国医学装备, 2022, 19: 1-7. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZB202211001.htm
    [9]
    Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects[J]. Pain Physician, 2008, 11: S105-S120.
    [10]
    Hagemeier NE. Introduction to the opioid epidemic: the economic burden on the healthcare system and impact on quality of life[J]. Am J Manag Care, 2018, 24: S200-S206.
    [11]
    Thurnheer SE, Gravestock I, Pichierri G, et al. Benefits of Mobile Apps in Pain Management: Systematic Review[J]. JMIR Mhealth Uhealth, 2018, 6: e11231. DOI: 10.2196/11231
    [12]
    罗尔丹, 白倩, 卞鹰, 成都市中老年慢性疼痛患者的治疗概况及移动医疗APP需求情况调查[J]. 临床医学研究与实践, 2021, 6: 10-13. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202115005.htm
    [13]
    Manini TM, Mendoza T, Battula M, et al. Perception of Older Adults Toward Smartwatch Technology for Assessing Pain and Related Patient-Reported Outcomes: Pilot Study[J]. JMIR Mhealth Uhealth, 2019, 7: e10044. DOI: 10.2196/10044
    [14]
    Yang J, Weng L, Chen Z, et al. Development and Testing of a Mobile App for Pain Management Among Cancer Patients Discharged From Hospital Treatment: Randomized Controlled Trial[J]. JMIR Mhealth Uhealth, 2019, 7: e12542. DOI: 10.2196/12542
    [15]
    Lee J, Park SH, Ju JH, et al. Application of a real-time pain monitoring system in Korean fibromyalgia patients: A pilot study[J]. Int J Rheum Dis, 2019, 22: 934-939. DOI: 10.1111/1756-185X.13472
    [16]
    Chen J, Abbod M, Shieh JS. Pain and Stress Detection Using Wearable Sensors and Devices-A Review[J]. Sensors (Basel), 2021, 21: 1030. DOI: 10.3390/s21041030
    [17]
    Rosser BA, Eccleston C. Smartphone applications for pain management[J]. J Telemed Telecare, 2011, 17: 308-312. DOI: 10.1258/jtt.2011.101102
    [18]
    Clement I, Lorenz A, Ulm B, et al. Implementing Systematically Collected User Feedback to Increase User Retention in a Mobile App for Self-Management of Low Back Pain: Retrospective Cohort Study[J]. JMIR Mhealth Uhealth, 2018, 6: e10422. DOI: 10.2196/10422
    [19]
    Shaygan M, Jaberi A. The effect of a smartphone-based pain management application on pain intensity and quality of life in adolescents with chronic pain[J]. Sci Rep, 2021, 11: 6588. DOI: 10.1038/s41598-021-86156-8
    [20]
    Blödt S, Pach D, Roll S, et al. Effectiveness of app-based relaxation for patients with chronic low back pain (Relaxback) and chronic neck pain (Relaxneck): study protocol for two randomized pragmatic trials[J]. Trials, 2014, 15: 490. DOI: 10.1186/1745-6215-15-490
    [21]
    林海玉, 郑珍丽, 陈伊文, 等. "互联网+"背景下采用"317护"APP对癌痛患者健康教育体会[J]. 中国农村卫生事业管理, 2018, 38: 771-773. DOI: 10.3969/j.issn.1005-5916.2018.06.024
    [22]
    阮兰红. 基于APP的放松疗法对慢性下腰痛患者情绪、疼痛和腰部功能的影响[J]. 颈腰痛杂志, 2022, 43: 37-40. https://www.cnki.com.cn/Article/CJFDTOTAL-JYTZ202201008.htm
    [23]
    Biebl JT, Rykala M, Strobel M, et al. App-Based Feedback for Rehabilitation Exercise Correction in Patients With Knee or Hip Osteoarthritis: Prospective Cohort Study[J]. J Med Internet Res, 2021, 23: 26658. DOI: 10.2196/26658
    [24]
    Priebe JA, Haas KK, Moreno Sanchez LF, et al. Digital Treatment of Back Pain versus Standard of Care: The Cluster-Randomized Controlled Trial, Rise-uP[J]. J Pain Res, 2020, 13: 1823-1838. DOI: 10.2147/JPR.S260761
    [25]
    Mahrer NE, Gold JI. The use of virtual reality for pain control: a review[J]. Curr Pain Headache Rep, 2009, 13: 100-109. DOI: 10.1007/s11916-009-0019-8
    [26]
    Mazurek J, Kiper P, Cielik B, et al. Virtual reality in medicine: A brief overview and future research directions[J]. Hum Movement, 2019, 20: 16-22.
    [27]
    Bushnell MC, Case LK, Ceko M, et al. Effect of environment on the long-term consequences of chronic pain[J]. Pain, 2015, 156: S42-S49. DOI: 10.1097/01.j.pain.0000460347.77341.bd
    [28]
    Macdonald G, Leary MR. Why does social exclusion hurt? The relationship between social and physical pain[J]. Psychol Bull, 2005, 131: 202-223. DOI: 10.1037/0033-2909.131.2.202
    [29]
    Gold JI, Belmont KA, Thomas DA. The neurobiology of virtual reality pain attenuation[J]. Cyberpsychol Behav, 2007, 10: 536-544. DOI: 10.1089/cpb.2007.9993
    [30]
    Hoffman HG, Doctor JN, Patterson DR, et al. Virtual reality as an adjunctive pain control during burn wound care in adolescent patients[J]. Pain, 2000, 85: 305-309. DOI: 10.1016/S0304-3959(99)00275-4
    [31]
    Gupta A, Scott K, Dukewich M. Innovative Technology Using Virtual Reality in the Treatment of Pain: Does It Reduce Pain via Distraction, or Is There More to It?[J]. Pain Med, 2018, 19: 151-159. DOI: 10.1093/pm/pnx109
    [32]
    Gromala D, Tong X, Choo A, et al. The Virtual Meditative Walk: Virtual Reality Therapy for Chronic Pain Management[C]. ACM CHI 2015. ACM, 2015. doi: 10.1145/2702123.2702344.
    [33]
    Hadjiat Y, Marchand S. Virtual Reality and the Mediation of Acute and Chronic Pain in Adult and Pediatric Populations: Research Developments[J]. Front Pain Res (Lausanne), 2022, 3: 840921. DOI: 10.3389/fpain.2022.840921
    [34]
    刘秋红. 基于虚拟现实的疼痛控制管理平台对行肝胆外科手术患者的干预效果[J]. 中西医结合护理, 2021, 7: 97-99. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXHL202109027.htm
    [35]
    张宁宁, 陈艺. 虚拟现实技术结合音乐干预对烧伤患者创面换药时疼痛程度及心率、血压的影响[J]. 解放军护理杂志, 2020, 37: 78-80. https://www.cnki.com.cn/Article/CJFDTOTAL-JFHL202011021.htm
    [36]
    Lee HJ. Digital therapeutics in pain medicine[J]. Korean J Pain, 2021, 34: 247-249. DOI: 10.3344/kjp.2021.34.3.247
    [37]
    巩树伟, 刘爱峰, 郎爽, 等. 虚拟现实技术对慢性疼痛治疗的应用进展[J]. 中国疼痛医学杂志, 2020, 26: 438-442. https://www.cnki.com.cn/Article/CJFDTOTAL-ZTYZ202006011.htm
    [38]
    Rubin R. Virtual Reality Device Is Authorized to Relieve Back Pain[J]. JAMA, 2021, 326: 2354.
    [39]
    Mevleviolu D, Murphy D, Tabirca SM. Visual Respiratory Feedback in Virtual Reality Exposure Therapy: A Pilot Study[C]. ACM International Conference on Interactive Media Experiences. Association for Computing Machinery, 2021. doi: 10.1145/3452918.3458799.
    [40]
    Stamm O, Dahms R, Müller-Werdan U. Virtual reality in pain therapy: a requirements analysis for older adults with chronic back pain[J]. J Neuroeng Rehabil, 2020, 17: 129.
    [41]
    Dahlberg LE, Grahn D, Dahlberg JE, et al. A Web-Based Platform for Patients With Osteoarthritis of the Hip and Knee: A Pilot Study[J]. JMIR Res Protoc, 2016, 5: e115.
    [42]
    Lalloo C, Nishat F, Zempsky W, et al. Characterizing User Engagement With a Digital Intervention for Pain Self-management Among Youth With Sickle Cell Disease and Their Caregivers: Subanalysis of a Randomized Controlled Trial[J]. J Med Internet Res, 2022, 24: e40096.
    [43]
    Tick H, Nielsen A, Pelletier KR, et al. Evidence-Based Nonpharmacologic Strategies for Comprehensive Pain Care: The Consortium Pain Task Force White Paper[J]. Explore (NY), 2018, 14: 177-211.
    [44]
    Bulaj G, Clark J, Ebrahimi M, et al. From Precision Metapharmacology to Patient Empowerment: Delivery of Self-Care Practices for Epilepsy, Pain, Depression and Cancer Using Digital Health Technologies[J]. Front Pharmacol, 2021, 12: 612602.
    [45]
    Metcalf CS, Huntsman M, Garcia G, et al. Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs[J]. Front Neurol, 2019, 10: 277.
    [46]
    Lee JH. The Effects of Music on Pain: A Meta-Analysis[J]. J Music Ther, 2016, 53: 430-477.
    [47]
    Shebib R, Bailey JF, Smittenaar P, et al. Randomized controlled trial of a 12-week digital care program in improving low back pain[J]. NPJ Digit Med, 2019, 2: 1.
    [48]
    Huber S, Priebe JA, Baumann KM, et al. Treatment of Low Back Pain with a Digital Multidisciplinary Pain Treatment App: Short-Term Results[J]. JMIR Rehabil Assist Technol, 2017, 4: e11.
    [49]
    van der Vaart R, van Driel D, Pronk K, et al. The Role of Age, Education, and Digital Health Literacy in the Usability of Internet-Based Cognitive Behavioral Therapy for Chronic Pain: Mixed Methods Study[J]. JMIR Form Res, 2019, 3: e12883.
    [50]
    Griffiths C, Foster G, Ramsay J, et al. How effective are expert patient (lay led) education programmes for chronic disease?[J]. BMJ, 2007, 334: 1254-1256.
    [51]
    陈玮. 智能手机使用对医学生颈痛影响的调查研究[D]. 青岛: 青岛大学, 2019.
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