Email Alert RSS
Volume 14 Issue 3
May  2023
Turn off MathJax
Article Contents
Abstract
References
Related Articles
SHEN Kaini, LI Jian. How can Clinicians Do A Good Job in RCT Research[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 617-620. DOI: 10.12290/xhyxzz.2022-0240
Citation: SHEN Kaini, LI Jian. How can Clinicians Do A Good Job in RCT Research[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 617-620. DOI: 10.12290/xhyxzz.2022-0240
shu

How can Clinicians Do A Good Job in RCT Research

  • Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

Fundamental Research Funds for the Central Universities 3332021002

More Information
  • Corresponding author:

    LI Jian, E-mail: lijian@pumch.cn

  • Received Date: April 28, 2022
  • Accepted Date: July 24, 2022
  • Available Online: August 01, 2022
  • Issue Publish Date: May 29, 2023
    Graphical Abstract
    • Abstract
  • Randomized controlled trial(RCT) provides the most valid means of establishing the efficacy of clinical therapeutics. A good RCT should be based on topics with clinical significance and scientific value, and focus on the establishment of intervention and control, the method of randomization and the selection of primary endpoints. During the implementation process, details such as ethics application, research registration, data collection and regular review of the research are of great value to ensure the scientific validity of the trials and the credibility of the results.
    • FullText(HTML)
    • References (6)
  • [1]
    Shen KN, Fu WJ, Wu Y, et al. Doxycycline Combined With Bortezomib-Cyclophosphamide-Dexamethasone Chemotherapy for Newly Diagnosed Cardiac Light-Chain Amyloi-dosis: A Multicenter Randomized Controlled Trial[J]. Circulation, 2022, 145: 8-17. DOI: 10.1161/CIRCULATIONAHA.121.055953
    [2]
    Schulz KF, Altman DG, Moher D, et al. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials[J]. Ann Intern Med, 2010, 152: 726-732. DOI: 10.7326/0003-4819-152-11-201006010-00232
    [3]
    Chan AW, Tetzlaff JM, Altman DG, et al. SPIRIT 2013 statement: defining standard protocol items for clinical trials[J]. Ann Intern Med, 2013, 158: 200-207. DOI: 10.7326/0003-4819-158-3-201302050-00583
    [4]
    Boutron I, Estellat C, Guittet L, et al. Methods of blinding in reports of randomized controlled trials assessing pharmacologic treatments: a systematic review[J]. PLoS Med, 2006, 3: e425. DOI: 10.1371/journal.pmed.0030425
    [5]
    Kahan BC, Morris TP. Reporting and analysis of trials using stratified randomisation in leading medical journals: review and reanalysis[J]. BMJ, 2012, 345: e5840. DOI: 10.1136/bmj.e5840
    [6]
    Glynne-Jones R, Glynne-Jones S. The concept and use of the neoadjuvant rectal score as a composite endpoint in rectal cancer[J]. Lancet Oncol, 2021, 22: e314-e326. DOI: 10.1016/S1470-2045(21)00053-X
    • Related Articles

  • Related Articles

    [1]LI Jinpeng, GUO Jie, LIU Tao, WEI Xiaotao, SONG Yuan, WANG Weiwei, HE Zhijun. Progress on the Main Mechanism Affecting Flap Survival[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(2): 416-422. DOI: 10.12290/xhyxzz.2024-0253
    [2]LIU Yan, DONG Xingang, WANG Xiaoyuan, QI Gege, REN Yiqin, ZHOU Lianpeng, LI Hui, ZHANG Suqing, LI Weifeng. Research Progress on the Correlation Between Mitophagy and Vascular Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(2): 338-349. DOI: 10.12290/xhyxzz.2024-0947
    [3]JIANG Yubin, WANG Xingming, ZHANG Yue, ZHOU Zhiqiang, YANG Jianjun. Esketamine Improves Working Memory Impairment in Neuropathic Mice Through Hippocampal BDNF-TrkB Pathway[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 328-334. DOI: 10.12290/xhyxzz.2023-0581
    [4]WANG Caihong, LIU Rongxin, TANG Feng, WEI Xiaotao, XU Ziqing, HOU Huaijing, ZHANG Jie, ZHAO Yongqiang, XUE Jianjun. Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1282-1288. DOI: 10.12290/xhyxzz.2023-0217
    [5]WANG Jie, LI Xiangmin. Protective Effect of Mesenchymal Stem Cells on Cerebral Ischemic Reperfusion Injury[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 472-477. DOI: 10.12290/xhyxzz.2022-0734
    [6]Xiang-yi KONG, Jian GUAN, Ren-zhi WANG. Neuroprotective Effects of p66Shc Knock-out on Hypoxic-ischemic Brain Injury in Mice[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(6): 359-363. DOI: 10.3969/j.issn.1674-9081.2017.06.008
    [7]Hong Yang, Shanshan Hu, Gechong Ruan, Xiaoou Yang, Jiaming Qian. Expression of ARHI and HuR in PANC-1 Cells[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(1): 39-42. DOI: 10.3969/j.issn.1674-9081.2017.01.009
    [8]Qian ZHANG, Xiao-chun LIANG, Qing SUN, Pu-yan WANG, Wen-zhi HUANG, Bo-wu LI, Yan-dong ZHANG, Yun-zhou GAO. Effect of Jinmaitong on Oxidative Stress in Dorsal Root Ganglion of Diabetic Rats[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 441-447. DOI: 10.3969/j.issn.1674-9081.2012.04.018
    [9]Xiao-hua SHI, Zhi-yong LIANG, Huan-wen WU, Xin-yu REN, Tong-hua LIU. Effect of RNA Interference Plasmid on the Expression of Oncogene AKT2 in Pancreatic Cancer Cell Line Panc-1[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 102-108. DOI: 10.3969/j.issn.1674-9081.2012.01.021
    [10]Jian CAO, Yi-ning WANG, Ling-yan KONG, Hua-dan XUE, Jing LEI, Yong-lan HE, Zhuo LI, Jie MENG, Zheng-yu JIN. SD Rat Adipose Derived Stem Cells Labeled with Ultrasmall Superparamagnetic Iron Oxide[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 252-257. DOI: 10.3969/j.issn.1674-9081.2011.03.013

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2503) PDF downloads (451) Cited by()
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close