Volume 13 Issue 2
Mar.  2022
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ZHAO Hua, LIU Dawei. How to Implement Personalized Therapy According to Clinical Guidelines: From International Guidelines for Management of Sepsis and Septic Shock[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 174-179. doi: 10.12290/xhyxzz.2021-0811
Citation: ZHAO Hua, LIU Dawei. How to Implement Personalized Therapy According to Clinical Guidelines: From International Guidelines for Management of Sepsis and Septic Shock[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 174-179. doi: 10.12290/xhyxzz.2021-0811

How to Implement Personalized Therapy According to Clinical Guidelines: From International Guidelines for Management of Sepsis and Septic Shock

doi: 10.12290/xhyxzz.2021-0811
Funds:

Beijing Science and Technology Project: Establishment and Application of Organ Hemodynamically Guided Sepsis Resuscitation Strategy Project Z201100005520038

More Information
  • Corresponding author: LIU Dawei, E-mail: dwliu@163.com
  • Received Date: 2021-12-31
  • Accepted Date: 2022-01-17
  • Available Online: 2022-01-17
  • Publish Date: 2022-03-30
  • Sepsis is a major cause of death world wide. Evidence-based SSC guidelines promoted the global medical staffs' awareness of sepsis and septic shock, strengthened the understanding of the occurrence and development, and provided a common ground for all clinicians. SSC guidelines are the premise of implementing "personalized"therapy, but management that strictly adheres to guidelines may not necessarily be the best option for each patient.Personalized management needs quantitative intervention according to the patient's pathophysiological characteristics and individual response. In this article, we will describe the correlation between "personalized" therapy and guidelines through the recommendations of 2021 SSC guidelines, and expound on how to implement personalized therapy according to clinical guidelines.
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  • [1] Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis compaign: international guidelines for management of sepsis and septic shock 2021[J]. Crit Care Med, 2021, 49: e1063-e1143.
    [2] Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock[J]. N Engl J Med, 2014, 370: 1583-1593. doi:  10.1056/NEJMoa1312173
    [3] Lamontagne F, Richards-Belle A, Thomas K, et al. Effect of reduced exposure to vasopressors on 90-day mortality in older critically ill patients with vasodilatory hypotension: a randomized clinical trial[J]. JAMA, 2020, 323: 938-949. doi:  10.1001/jama.2020.0930
    [4] Hernández G, Ospina-Tascón GA, Damiani LP, et al. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial[J]. JAMA, 2019, 321: 654-664. doi:  10.1001/jama.2019.0071
    [5] Zampieri FG, Damiani LP, Bakker J, et al. Effects of a Resuscitation Strategy Targeting Peripheral Perfusion Status versus Serum Lactate Levels among Patients with Septic Shock, A Bayesian Reanalysis of the ANDROMEDA-SHOCK Trial[J]. Am J Respir Crit Care Med, 2020, 201: 423-429. doi:  10.1164/rccm.201905-0968OC
    [6] Liu R, Greenstein JL, Granite SJ, et al. Data-driven discovery of a novel sepsis preshock state predicts impending septic shock in the ICU[J]. Sci Rep, 2019, 9: 6145. doi:  10.1038/s41598-019-42637-5
    [7] De Backer D, Orbegozo Cortes D, Donadello K, et al. Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock[J]. Virulence, 2014, 5: 73-79. doi:  10.4161/viru.26482
    [8] 刘大为, 王小亭, 张宏民, 等. 重症血流动力学治疗——北京共识[J]. 中华内科杂志, 2015, 54: 248-271. doi:  10.3760/cma.j.issn.0578-1426.2015.03.021
    [9] Beaubien-Souligny W, Rola P, Haycock K, et al. Quantifying systemic congestion with Point-Of-Care ultrasound: development of the venous excess ultrasound grading system[J]. Ultrasound J, 2020, 12: 16. doi:  10.1186/s13089-020-00163-w
    [10] De-Lima-Oliveira M, Salinet ASM, Nogueira RC, et al. Intracranial Hypertension and Cerebral Autoregulation: A systematic review and meta-analysis[J]. World Neurosurg, 2018, 113: 110-124. doi:  10.1016/j.wneu.2018.01.194
    [11] Sheridan DC, Cloutier R, Kibler A, et al. Cutting-Edge technology for rapid beside assessment of capillary refill time for early diagnosis and resuscitation of sepsis[J]. Front Med (Lausanne), 2020, 7: 612303.
    [12] Geri G, Vignon P, Aubry A, et al. Cardiovascular clusters in septic shock combining clinical and echocardiographic parameters: a posthoc analysis[J]. Intensive Care Med, 2019, 45: 657-667. doi:  10.1007/s00134-019-05596-z
    [13] Du W, Liu D, Long Y, et al. The β-Blocker Esmolol Restores the Vascular Waterfall Phenomenon After Acute Endotoxemia[J]. Crit Care Med, 2017, 45: e1247-e1253. doi:  10.1097/CCM.0000000000002721
    [14] Lat I, Coopersmith CM, De Backer D, et al. The surviv-ing sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients[J]. Intensive Care Med Exp, 2021, 9: 10. doi:  10.1186/s40635-021-00369-9
    [15] Khanna A, English SW, Wang XS, et al. Angiotensin Ⅱ for the Treatment of Vasodilatory Shock[J]. N Engl J Med, 2017, 377: 419-430. doi:  10.1056/NEJMoa1704154
    [16] Porizka M, Kopecky P, Dvorakova H, et al. Methylene blue administration in patients with refractory distributive shock-a retrospective study[J]. Sci Rep, 2020, 10: 1828. doi:  10.1038/s41598-020-58828-4
    [17] Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock[J]. N Engl J Med, 2008, 358: 877-887. doi:  10.1056/NEJMoa067373
    [18] Gordon AC, Mason AJ, Thirunavukkarasu N, et al. Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial[J]. JAMA, 2016, 316: 509-518. doi:  10.1001/jama.2016.10485
    [19] Nagendran M, Russell JA, Walley KR, et al. Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials[J]. Intensive Care Med, 2019, 45: 844-855. doi:  10.1007/s00134-019-05620-2
    [20] Liu ZM, Chen J, Kou Q, et al. Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial[J]. Intensive Care Med, 2018, 44: 1816-1825. doi:  10.1007/s00134-018-5267-9
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