| Citation: |
WU Juncheng, XUE Huadan. Advances in Magnetic-Optical Multimodality Molecular Imaging for Precision Diagnosis and Treatment of Pancreatic Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 877-883. DOI: 10.12290/xhyxzz.2024-0193
|
Pancreatic cancer, one of the most lethal cancers in the world, has been increasing in incidence and mortality year by year, and the overall prognosis of patients is poor. Early detection and effective treatment are crucial for improving the prognosis and survival rates of pancreatic cancer patients. Unlike traditional imaging, emerging molecular imaging can visualize the abnormalities at the molecular or cellular level in the process of tumor development. At present, multimodality molecular imaging that integrates multiple imaging methods to achieve complementary advantages and multifunctional nanoplatforms with integrated diagnosis and treatment functions have become research hotspots in the field of molecular imaging. Remarkable progress has been made in preclinical research concerning magnetic-optical multimodality molecular imaging probes and their derived multifunctional nanoplatforms, which provides new ideas for early detection, accurate treatment and efficacy evaluation of pancreatic cancer.
| [1] |
Siegel R L, Giaquinto A N, Jemal A. Cancer statistics, 2024[J]. CA Cancer J Clin, 2024, 74(1): 12-49. DOI: 10.3322/caac.21820
|
| [2] |
张浩, 洪夏飞, 吴文铭. 胰腺癌筛查与早期诊断的现状、挑战与展望[J]. 中华胰腺病杂志, 2024, 24(1): 1-4. DOI: 10.3760/cma.j.cn115667-20231016-00042
Zhang H, Hong X F, Wu W M. Current status, challenges and prospects of pancreatic cancer screening and early diagnosis[J]. Chin J Pancreatol, 2024, 24(1): 1-4. DOI: 10.3760/cma.j.cn115667-20231016-00042
|
| [3] |
郑荣寿, 张思维, 孙可欣, 等. 2016年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志, 2023, 45(3): 212-220. DOI: 10.3760/cma.j.cn112152-20220922-00647
Zheng R S, Zhang S W, Sun K X, et al. Cancer statistics in China, 2016[J]. Chin J Oncol, 2023, 45(3): 212-220. DOI: 10.3760/cma.j.cn112152-20220922-00647
|
| [4] |
Hidalgo M, Cascinu S, Kleeff J, et al. Addressing the challenges of pancreatic cancer: future directions for improving outcomes[J]. Pancreatology, 2015, 15(1): 8-18. DOI: 10.1016/j.pan.2014.10.001
|
| [5] |
Siegel R L, Miller K D, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1): 7-30. DOI: 10.3322/caac.21590
|
| [6] |
Mizrahi J D, Surana R, Valle J W, et al. Pancreatic cancer[J]. Lancet, 2020, 395(10242): 2008-2020. DOI: 10.1016/S0140-6736(20)30974-0
|
| [7] |
Zeng H M, Chen W Q, Zheng R S, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries[J]. Lancet Glob Health, 2018, 6(5): e555-e567. DOI: 10.1016/S2214-109X(18)30127-X
|
| [8] |
中华医学会肿瘤学分会早诊早治学组. 中华医学会肿瘤学分会胰腺癌早诊早治专家共识[J]. 临床肝胆病杂志, 2020, 36(12): 2675-2680. DOI: 10.3969/j.issn.1001-5256.2020.12.008
Early Diagnosis and Treatment Group, the Oncology Committee of Chinese Medical Association. Expert consensus of Oncology Committee of Chinese Medical Association in early diagnosis and treatment of pancreatic cancer[J]. J Clin Hepatol, 2020, 36(12): 2675-2680. DOI: 10.3969/j.issn.1001-5256.2020.12.008
|
| [9] |
Pereira S P, Oldfield L, Ney A, et al. Early detection of pancreatic cancer[J]. Lancet Gastroenterol Hepatol, 2020, 5(7): 698-710. DOI: 10.1016/S2468-1253(19)30416-9
|
| [10] |
Noda Y, Ando T, Kaga T, et al. Pancreatic cancer detection with dual-energy CT: diagnostic performance of 40 keV and 70 keV virtual monoenergetic images[J]. Radiol Med, 2024, 129(5): 677-686. DOI: 10.1007/s11547-024-01806-x
|
| [11] |
Park W, Chawla A, O'Reilly E M. Pancreatic cancer: a review[J]. JAMA, 2021, 326(9): 851-862. DOI: 10.1001/jama.2021.13027
|
| [12] |
柳梅, 冷德文, 范学朋. 多模态分子影像的研究进展[J]. 中国医学影像学杂志, 2018, 26(6): 471-475. DOI: 10.3969/j.issn.1005-5185.2018.06.018
Liu M, Leng D W, Fan X P. Research progress in multimodal molecular imaging[J]. Chin J Med Imaging, 2018, 26(6): 471-475. DOI: 10.3969/j.issn.1005-5185.2018.06.018
|
| [13] |
姜杨宏岩, 冯蓓, 于亚萍, 等. 靶向肿瘤微环境标志物及其分子影像学应用进展[J]. 中国医学影像学杂志, 2022, 30(12): 1309-1313. DOI: 10.3969/j.issn.1005-5185.2022.12.022
Jiang Y H Y, Feng B, Yu Y P, et al. Targeting tumor microenvironmental markers and application progress in molecular imaging[J]. Chin J Med Imaging, 2022, 30(12): 1309-1313. DOI: 10.3969/j.issn.1005-5185.2022.12.022
|
| [14] |
Li S T, Ma Z Y, Zhang K, et al. A two-pronged strategy for enhanced deep-tumor penetration and NIR-Ⅱ multimodal imaging-monitored photothermal therapy[J]. ACS Appl Mater Interfaces, 2022, 14(37): 41684-41694. DOI: 10.1021/acsami.2c08930
|
| [15] |
LI B, WANG W, ZHAO L, et al. Multifunctional AIE nanosphere-based "nanobomb" for trimodal imaging-guided photothermal/photodynamic/pharmacological therapy of drug-resistant bacterial infections[J]. ACS Nano, 2023, 17(5): 4601-4618. DOI: 10.1021/acsnano.2c10694
|
| [16] |
Harinck F, Konings I C A W, Kluijt I, et al. A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals[J]. Gut, 2016, 65(9): 1505-1513. DOI: 10.1136/gutjnl-2014-308008
|
| [17] |
YANG Y, JIANG Q Y, ZHANG F. Nanocrystals for deep-tissue in vivo luminescence imaging in the near-infrared region[J]. Chem Rev, 2024, 124(2): 554-628. DOI: 10.1021/acs.chemrev.3c00506
|
| [18] |
Li Z Q, Li Z, Ramos A, et al. Detection of pancreatic cancer by indocyanine green-assisted fluorescence imaging in the first and second near-infrared Windows[J]. Cancer Commun (Lond), 2021, 41(12): 1431-1434. DOI: 10.1002/cac2.12236
|
| [19] |
Zhang X, Zeng Z M, Liu H Y, et al. Recent development of a magneto-optical nanoplatform for multimodality imaging of pancreatic ductal adenocarcinoma[J]. Nanoscale, 2022, 14(9): 3306-3323. DOI: 10.1039/D1NR08394E
|
| [20] |
Shuvaev S, Akam E, Caravan P. Molecular MR contrast agents[J]. Invest Radiol, 2021, 56(1): 20-34. DOI: 10.1097/RLI.0000000000000731
|
| [21] |
Peng L G, Li Y C, Yao S, et al. Urokinase-type plasminogen activator receptor (uPAR) cooperates with mutated KRAS in regulating cellular plasticity and gemcitabine response in pancreatic adenocarcinomas[J]. Cancers (Basel), 2023, 15(5): 1587. DOI: 10.3390/cancers15051587
|
| [22] |
Yang L, Mao H, Cao Z H, et al. Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles[J]. Gastroenterology, 2009, 136(5): 1514-1525. e2. DOI: 10.1053/j.gastro.2009.01.006
|
| [23] |
Hildenbrand R, Niedergethmann M, Marx A, et al. Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group[J]. Am J Pathol, 2009, 174(6): 2246-2253. DOI: 10.2353/ajpath.2009.080785
|
| [24] |
Li H, Wang P, Gong W Y, et al. Dendron-grafted polylysine-based dual-modal nanoprobe for ultra-early diagnosis of pancreatic precancerosis via targeting a urokinase-type plasminogen activator receptor[J]. Adv Healthc Mater, 2018, 7(5): 1700912. DOI: 10.1002/adhm.201700912
|
| [25] |
Bausch D, Thomas S, Mino-Kenudson M, et al. Plectin-1 as a novel biomarker for pancreatic cancer[J]. Clin Cancer Res, 2011, 17(2): 302-309. DOI: 10.1158/1078-0432.CCR-10-0999
|
| [26] |
Chen X, Zhou H, Li X S, et al. Plectin-1 targeted dual-modality nanoparticles for pancreatic cancer imaging[J]. EBioMedicine, 2018, 30: 129-137. DOI: 10.1016/j.ebiom.2018.03.008
|
| [27] |
Harvell-Smith S, Tung L D, Thanh N T K. Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality[J]. Nanoscale, 2022, 14(10): 3658-3697. DOI: 10.1039/D1NR05670K
|
| [28] |
Smith B R, Gambhir S S. Nanomaterials for in vivo imaging[J]. Chem Rev, 2017, 117(3): 901-986. DOI: 10.1021/acs.chemrev.6b00073
|
| [29] |
Han X, Li Y, Liu W F, et al. The applications of magnetic particle imaging: from cell to body[J]. Diagnostics (Basel), 2020, 10(10): 800. DOI: 10.3390/diagnostics10100800
|
| [30] |
Zhang W J, Liang X L, Zhu L, et al. Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice[J]. EBioMedicine, 2022, 80: 104040. DOI: 10.1016/j.ebiom.2022.104040
|
| [31] |
Connor A A, Gallinger S. Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data[J]. Nat Rev Cancer, 2022, 22(3): 131-142. DOI: 10.1038/s41568-021-00418-1
|
| [32] |
Yao H J, Song W P, Cao R, et al. An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms[J]. Nat Commun, 2022, 13(1): 5506. DOI: 10.1038/s41467-022-33037-x
|
| [33] |
Shin S J, Smith J A, Rezniczek G A, et al. Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer[J]. Proc Natl Acad Sci U S A, 2013, 110(48): 19414-19419. DOI: 10.1073/pnas.1309720110
|
| [34] |
Wang Q, Yan H, Jin Y S, et al. A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer[J]. Biomaterials, 2018, 183: 173-184. DOI: 10.1016/j.biomaterials.2018.08.048
|
| [35] |
Chen Y L, Yin B, Liu Z, et al. Dual-modality magnetic resonance/optical imaging-guided sonodynamic therapy of pancreatic cancer with metal-organic nanosonosensitizer[J]. Nano Res, 2022, 15(7): 6340-6347. DOI: 10.1007/s12274-022-4284-8
|
| [36] |
Wang M Z, Wang Y, Fu Q R. Magneto-optical nanosystems for tumor multimodal imaging and therapy in-vivo[J]. Mater Today Bio, 2024, 26: 101027. DOI: 10.1016/j.mtbio.2024.101027
|
| [37] |
Zhou G Y, Xiao H, Li X X, et al. Gold nanocage decorated pH-sensitive micelle for highly effective photothermo-chemotherapy and photoacoustic imaging[J]. Acta Biomater, 2017, 64: 223-236. DOI: 10.1016/j.actbio.2017.10.018
|
| [38] |
Li C M, Zhao T Y, Li L X, et al. Stimuli-responsive gold nanocages for cancer diagnosis and treatment[J]. Pharmaceutics, 2022, 14(7): 1321. DOI: 10.3390/pharmaceutics14071321
|
| [39] |
Qiu W L, Zhang H F, Chen X, et al. A GPC1-targeted and gemcitabine-loaded biocompatible nanoplatform for pancre-atic cancer multimodal imaging and therapy[J]. Nanomedicine (Lond), 2019, 14(17): 2339-2353. DOI: 10.2217/nnm-2019-0063
|
| [40] |
国家卫生健康委办公厅. 胰腺癌诊疗指南(2022年版)[J]. 临床肝胆病杂志, 2022, 38(5): 1006-1015. DOI: 10.3969/j.issn.1001-5256.2022.05.007
General Office of National Health Commission. Standard for diagnosis and treatment of pancreatic cancer (2022 edition)[J]. J Clin Hepatol, 2022, 38(5): 1006-1015. DOI: 10.3969/j.issn.1001-5256.2022.05.007
|
| [41] |
Erstad D J, Sojoodi M, Taylor M S, et al. Fibrotic response to neoadjuvant therapy predicts survival in pancreatic cancer and is measurable with collagen-targeted molecular MRI[J]. Clin Cancer Res, 2020, 26(18): 5007-5018. DOI: 10.1158/1078-0432.CCR-18-1359
|
| [42] |
Han Z, Zhang S X, Fujiwara K, et al. Extradomain-B fibronectin-targeted dextran-based chemical exchange satura-tion transfer magnetic resonance imaging probe for detecting pancreatic cancer[J]. Bioconjug Chem, 2019, 30(5): 1425-1433. DOI: 10.1021/acs.bioconjchem.9b00161
|
| [43] |
Zhang W J, Liang X L, Zhang X Y, et al. Magnetic-optical dual-modality imaging monitoring chemotherapy efficacy of pancreatic ductal adenocarcinoma with a low-dose fibronectin-targeting Gd-based contrast agent[J]. Eur J Nucl Med Mol Imaging, 2024, 51(7): 1841-1855. DOI: 10.1007/s00259-024-06617-w
|
| [44] |
Bear A S, Vonderheide R H, O'Hara M H. Challenges and opportunities for pancreatic cancer immunotherapy[J]. Cancer Cell, 2020, 38(6): 788-802. DOI: 10.1016/j.ccell.2020.08.004
|
| [45] |
Schizas D, Charalampakis N, Kole C, et al. Immunotherapy for pancreatic cancer: a 2020 update[J]. Cancer Treat Rev, 2020, 86: 102016. DOI: 10.1016/j.ctrv.2020.102016
|
| [46] |
ZHANG H F, CHEN K, GUO K, et al. Multimodal imaging-guided photoimmunotherapy of pancreatic cancer by organosilica nanomedicine[J]. Adv Healthc Mater, 2024, 13(2): e2302195. DOI: 10.1002/adhm.202302195
|
| [47] |
Okuno T, Kato S, Hatakeyama Y, et al. Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light[J]. J Control Release, 2013, 172(3): 879-884. DOI: 10.1016/j.jconrel.2013.10.014
|
| [48] |
Wang S, Zhang Q, Luo X F, et al. Magnetic graphene-based nanotheranostic agent for dual-modality mapping guided photothermal therapy in regional lymph nodal metastasis of pancreatic cancer[J]. Biomaterials, 2014, 35(35): 9473-9483. DOI: 10.1016/j.biomaterials.2014.07.064
|
| [49] |
Herskovits E H. Artificial intelligence in molecular imaging[J]. Ann Transl Med, 2021, 9(9): 824. DOI: 10.21037/atm-20-6191
|
| [50] |
Xu H, Yuan J T, Ma J Y. MURF: mutually reinforcing multi-modal image registration and fusion[J]. IEEE Trans Pattern Anal Mach Intell, 2023, 45(10): 12148-12166. DOI: 10.1109/TPAMI.2023.3283682
|
| [51] |
Wahl R L. The interaction of genomics, molecular imaging, and therapy in gastrointestinal tumors[J]. Semin Nucl Med, 2020, 50(5): 471-483. DOI: 10.1053/j.semnuclmed.2020.06.002
|
| [52] |
LIU Y, CHEN Y M, HAN L. Bioinformatics: advancing biomedical discovery and innovation in the era of big data and artificial intelligence[J]. Innov Med, 2023, 1(1): 100012. DOI: 10.59717/j.xinn-med.2023.100012
|
| [1] | YAN Xinchun, HUO Li. Evaluation of Von Hippel-Lindau Syndrome Through Novel Small Molecular Tracer 68Ga-NY104 PET/CT Imaging[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 911-915. DOI: 10.12290/xhyxzz.2024-0216 |
| [2] | ZHAO Yizhou, LI Jianing, WANG Qiang, WU Dongsheng, ZHANG Shengyu, WU Xi, GUO Tao, JIANG Qingwei, YANG Yingyun, SHI Wen, FENG Yunlu, YANG Aiming. The Efficacy of Combined Endoscopic Ultrasound Fine-needle Aspiration and Endoscopic Retrograde Cholangiopancreatography in Same Session for the Diagnosis and Management of Pancreatic Carcinoma with Obstructive Jaundice[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 819-824. DOI: 10.12290/xhyxzz.2024-0207 |
| [3] | LUO Yaping, LI Fang. Current Status and Future Prospects of Theranostics with Radiopharmaceuticals[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 669-672. DOI: 10.12290/xhyxzz.2023-0236 |
| [4] | CHEN Yue. Development and Prospect of Theranostic Medical Isotopes and Radiopharmaceuticals in China[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 187-191. DOI: 10.12290/xhyxzz.2021-0557 |
| [5] | LIU Qingxing, CHEN Xiaoyuan, ZHU Zhaohui. Clinical Translational Research of Evans Blue Modified Peptides Used for Theranostics[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 180-186. DOI: 10.12290/xhyxzz.2021-0764 |
| [6] | WANG Guochang, ZHU Zhaohui. Molecular Imaging-guided Precise Theranostics[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 165-168. DOI: 10.12290/xhyxzz.2021-0773 |
| [7] | Ming HE, Hua-dan XUE, Zheng-yu JIN, Yu-pei ZHAO. State-of-the-art Imaging in the Diagnosis and Treatment of Pancreatic Ductal Carcinoma: Current Role and Value[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(1): 11-18. DOI: 10.3969/j.issn.1674-9081.2019.01.003 |
| [8] | Hong Yang, Shanshan Hu, Gechong Ruan, Xiaoou Yang, Jiaming Qian. Expression of ARHI and HuR in PANC-1 Cells[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(1): 39-42. DOI: 10.3969/j.issn.1674-9081.2017.01.009 |
| [9] | Xiao-hua SHI, Zhi-yong LIANG, Huan-wen WU, Xin-yu REN, Tong-hua LIU. Effect of RNA Interference Plasmid on the Expression of Oncogene AKT2 in Pancreatic Cancer Cell Line Panc-1[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 102-108. DOI: 10.3969/j.issn.1674-9081.2012.01.021 |
| [10] | Xin-yu REN, Yu-feng YIN, Jie GAO, Sha-fei WU, Ke WANG, Wen-ze WANG, Xuan ZENG, Zhi-yong LIANG. Detection of HER2/neu Gene in Pancreatic and Gastric Adenocarcinoma among Chinese Patients[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 21-25. DOI: 10.3969/j.issn.1674-9081.2012.01.006 |
| 1. |
唐雯洁. 人工智能助手“小胰宝”在老年胰腺癌患者中的应用研究进展. 老年医学与保健. 2025(01): 267-269 .
|
Supported by: Beijing Renhe Information Technology Co., Ltd. 
Submit
Review
Office
Email Alert
RSS
DownLoad: