Volume 13 Issue 2
Mar.  2022
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LIU Qingxing, CHEN Xiaoyuan, ZHU Zhaohui. Clinical Translational Research of Evans Blue Modified Peptides Used for Theranostics[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 180-186. doi: 10.12290/xhyxzz.2021-0764
Citation: LIU Qingxing, CHEN Xiaoyuan, ZHU Zhaohui. Clinical Translational Research of Evans Blue Modified Peptides Used for Theranostics[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 180-186. doi: 10.12290/xhyxzz.2021-0764

Clinical Translational Research of Evans Blue Modified Peptides Used for Theranostics

doi: 10.12290/xhyxzz.2021-0764
Funds:

National Natural Science Foundation of China 81871392

The Capital Health Development Scientific Research Project 2018-1-4011

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-016

CAMS Clinical and Translational Medicine Research Fund 2019XK320032

More Information
  • Corresponding author: CHEN Xiaoyuan, E-mail: chen.shawn@nus.edu.sg; ZHU Zhaohui, E-mail: zhuzhh@pumch.cn
  • Received Date: 2021-12-01
  • Accepted Date: 2021-12-29
  • Available Online: 2022-01-12
  • Publish Date: 2022-03-30
  • Peptide receptor radionuclide therapy (PRRT) specifically uses radiolabeled peptides as biological targeting vectors designed to deliver cytotoxic levels of radiation dose to cancer cells that overexpress specific receptors. In recent years, how to further improve the efficacy of radiotherapeutic drugs for PRRT has been an international research hotspot.The peptides with Evans blue motif, uses endogenous albumin as a reversible carrier to effectively extend the half-life in the blood and substantially increase targeted accumulation and retention within the tumor to achieve better efficacy. This review focuses on the clinical translational research of Evans blue modified peptides used for theranostics.
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