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肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展

苏鹏飞,  于健春

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文章导航 > 协和医学杂志  > 2022 > 优先出版
苏鹏飞, 于健春. 肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2021-0605
引用本文: 苏鹏飞, 于健春. 肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2021-0605
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SU Pengfei, YU Jianchun. Research Progress on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2021-0605
Citation: SU Pengfei, YU Jianchun. Research Progress on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2021-0605
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肿瘤相关巨噬细胞与肿瘤耐药及治疗研究进展

doi: 10.12290/xhyxzz.2021-0605

  • 中国医学科学院北京协和医院基本外科，北京 100730

基金项目: 

北京市科学技术委员会基金（D171100006517002）

详细信息
    通讯作者:

    于健春,E-mail:yu-jch@163.com

  • 中图分类号: R730.5

Research Progress on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors

  • Department of General Surgery， Peking Union Medical College Hospital， Chinese Academy of Medical Sciences & Peking Union Medical College， Beijing 100730， China

Funds: 

Beijing Municipal Commission of Science and Technology Foundation (D171100006517002)

    摘要
  • 摘要: 肿瘤耐药的产生是肿瘤细胞与肿瘤微环境（tumor microenvironment，TME）相互作用的结果，肿瘤相关巨噬细胞（tumor-associated macrophages，TAMs）是TME中的主要免疫细胞，在炎症微环境和肿瘤细胞的恶性表型之间发挥桥梁作用，与肿瘤耐药和进展密切相关，其中M2型TAMs的浸润则预示着不良的临床结局。本文主要针对TAMs参与肿瘤耐药的作用机制和治疗进展进行综述，为探寻减少肿瘤耐药、增强抗肿瘤治疗策略提供参考。
    Abstract: The development of drug-resistance is the interactional result between tumor cells and tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the main immune cells in TME， and act as the bridge between inflammatory microenviroment and malignant phenotype of tumor cells. They are closely related to drug-resistance and tumor progression， and the infiltration of M2 macrophages indicates a poor clinical outcome. This paper reviews the research progress of the role of TAMs in drug-resistance and treatment of tumors， providing references for decreasing drug-resistance and increasing the curative effects.
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    • 参考文献(56)
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出版历程
  • 收稿日期:  2021-08-20
  • 录用日期:  2021-10-12
  • 网络出版日期:  2022-04-14

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