Volume 1 Issue 1
Jul.  2010
Turn off MathJax
Article Contents
Xiao-Jiang ZHANG, Xiu-li XIE, Hong-li SUN, Qi-wen YANG, Hui WANG, Ying-chun XU. Pathogens and Antibiotic Resistance of Isolates from Patients with Urinary Tract Infections in Peking Union Medical College Hospital, 1990-2009[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(1): 87-90.
Citation: Xiao-Jiang ZHANG, Xiu-li XIE, Hong-li SUN, Qi-wen YANG, Hui WANG, Ying-chun XU. Pathogens and Antibiotic Resistance of Isolates from Patients with Urinary Tract Infections in Peking Union Medical College Hospital, 1990-2009[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(1): 87-90.

Pathogens and Antibiotic Resistance of Isolates from Patients with Urinary Tract Infections in Peking Union Medical College Hospital, 1990-2009

More Information
  • Corresponding author: XU Ying-chun Tel: 010-65295406, E-mail:xycpumch@yahoo.com.cn
  • Received Date: 2010-04-08
  • Publish Date: 2010-07-30
  •   Objective  To identify the common pathogens of urinary tract infections and the potential existence of drug resistance.  Methods  A total of 4565 clinical isolates from patients with urinary tract infections were collected in Peking Union Medical College Hospital from 1990 to 2009. Antimicrobial susceptibility was detected by disk diffusion method.  Results  The most common pathogen identified was E. coli (33%), followed by Enterococcus faecalis (12%), Enterococcus faecium (8%), coagulase negative staphylococcus (7%), Pseudomonas aeruginosa (6%), and Klebsiella pneumoniae (6%). Extended-spectrum beta-lactamases (ESBLs)-producing strains in E. coli isolate was 60% from 2006 to 2009. Strains of E. coli and K. pneumoniae were still highly susceptible to imipenem, meropenem, and ertapenem. The resistance rates of E. coli strains to ciprofloxacin and levofloxacin were 77.7% and 76.4%, respectively. The resistance rates of E. faecalis to nitrofurantoin and fosfomycin were lower than 10%.  Conclusion  E. coli is the main cause of urinary tract infection. Bacterial resistance remains a major concern and more efforts should be made in the monitoring of drug resistance.
  • loading
  • [1] Clinical and Laboratory Standards Institute (CLSI). M100S20Performance standards for antimicrobial susceptibility testing[S]. 2010.
    [2] Stamm WE, Norrby RS. Urinary tract infections: disease panorama and challenges[J]. J Infect Dis, 2001, 183: S1S4.
    [3] WHO. Epidemiology of nosocomial infections[M] // WHO. Prevention of hospital acquired infections: a practical guide. 2nd ed. Geneva: WHO, 2002: 5.
    [4] Matsumoto T, Muratani T. Newer carbapenems for urinary tract ifections[J]. Int J Antimicrob Agents, 2004, 24: S35-S38. https://www.sciencedirect.com/science/article/pii/S0924857904000925
    [5] Piddock LJ. Mechanisms of fluoroquinolone resistance: an update 1994-1998[J]. Drugs, 1999, 58: S11-S18. http://cn.bing.com/academic/profile?id=3eb15cc88c45182c70ea502252706f9d&encoded=0&v=paper_preview&mkt=zh-cn
    [6] Nordmann P, Poirel L. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae[J]. J Antimicrob Chemother, 2005, 56: 463-469. doi:  10.1093/jac/dki245
    [7] Lautenbach E, Fishman NO, Bilker WB, et al. Risk factors for fluoroquinolone resistance in nosocomial Escherichia coli and Klebsiella pneumoniae infections[J]. Arch Inern Med, 2002, 162: 2469-2477. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zhlcgrbzz201205006
    [8] Olson RP, Harell UJ, Kaye KS. Antibiotic resistance in urinary isolates of Escherichia coli from college women with urinary tract infections[J]. Antimicrob Agents Chemother, 2009, 53: 1285-1286.
    [9] Javiya VA, Ghatak SB, Patel KR, et al. Antibiotic susceptibility patterns of Pseudomonas aeruginosa at a tertiary care hospital in Gujarat[J]. Indian J Pharmacol, 2008, 40: 230-234. doi:  10.4103/0253-7613.44156
    [10] Thean YT, Siew YN, Wan XN. Clinical significance of coagulase-negative staphylococci recovered from nonsterile sites[J]. J Clin Microbiol, 2006, 44: 3413-3414. doi:  10.1128/JCM.00757-06
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Article Metrics

    Article views (160) PDF downloads(8) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return