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Volume 1 Issue 1
Jul.  2010
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Xiao-Jiang ZHANG, Xiu-li XIE, Hong-li SUN, Qi-wen YANG, Hui WANG, Ying-chun XU. Pathogens and Antibiotic Resistance of Isolates from Patients with Urinary Tract Infections in Peking Union Medical College Hospital, 1990-2009[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(1): 87-90.
Citation: Xiao-Jiang ZHANG, Xiu-li XIE, Hong-li SUN, Qi-wen YANG, Hui WANG, Ying-chun XU. Pathogens and Antibiotic Resistance of Isolates from Patients with Urinary Tract Infections in Peking Union Medical College Hospital, 1990-2009[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(1): 87-90.
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Pathogens and Antibiotic Resistance of Isolates from Patients with Urinary Tract Infections in Peking Union Medical College Hospital, 1990-2009

  • Laboratory of Clinical Microbiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    XU Ying-chun Tel: 010-65295406, E-mail:xycpumch@yahoo.com.cn

  • Received Date: April 07, 2010
  • Issue Publish Date: July 29, 2010
    Graphical Abstract
    • Abstract
  •   Objective  To identify the common pathogens of urinary tract infections and the potential existence of drug resistance.
      Methods  A total of 4565 clinical isolates from patients with urinary tract infections were collected in Peking Union Medical College Hospital from 1990 to 2009. Antimicrobial susceptibility was detected by disk diffusion method.
      Results  The most common pathogen identified was E. coli (33%), followed by Enterococcus faecalis (12%), Enterococcus faecium (8%), coagulase negative staphylococcus (7%), Pseudomonas aeruginosa (6%), and Klebsiella pneumoniae (6%). Extended-spectrum beta-lactamases (ESBLs)-producing strains in E. coli isolate was 60% from 2006 to 2009. Strains of E. coli and K. pneumoniae were still highly susceptible to imipenem, meropenem, and ertapenem. The resistance rates of E. coli strains to ciprofloxacin and levofloxacin were 77.7% and 76.4%, respectively. The resistance rates of E. faecalis to nitrofurantoin and fosfomycin were lower than 10%.
      Conclusion  E. coli is the main cause of urinary tract infection. Bacterial resistance remains a major concern and more efforts should be made in the monitoring of drug resistance.
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    • References (10)
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