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Volume 11 Issue 3
May  2020
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Bei-di CHEN, Li-dan ZHAO, Xuan ZHANG. Gut Microbiota and Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 258-263. DOI: 10.3969/j.issn.1674-9081.20200056
Citation: Bei-di CHEN, Li-dan ZHAO, Xuan ZHANG. Gut Microbiota and Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 258-263. DOI: 10.3969/j.issn.1674-9081.20200056
shu

Gut Microbiota and Systemic Lupus Erythematosus

  • Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    ZHAO Li-dan  Tel: 86-10-69159952, E-mail:zhaolidan@hotmail.com

  • Received Date: February 29, 2020
  • Issue Publish Date: May 29, 2020
    Graphical Abstract
    • Abstract
  • Systemic lupus erythematosus (SLE) is a common autoimmune disease characterized by chronic inflammation and multi-organ damage and mainly affects women of childbearing age. SLE can only be controlled but not cured currently. The occurrence and development of SLE were reported to be associated with genetic factors as well as environmental triggers. In recent years, mounting evidence showed that there were compositional and functional changes in the gut microbiota of SLE patients. Also, the disturbed gut microbiota was suggested to partake in SLE pathogenesis by damaging the gut barrier, as well as inducing or aggravating chronic inflammation and autoimmunity. This review summarized the progress of research on the gut microbiota in SLE, discussed the clinical value of gut microbiota-related interventions, and envisions the future direction of research related to gut microbiota in lupus.
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    • References (40)
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