Volume 14 Issue 2
Mar.  2023
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SHEN Tian, WU Xiaochuan. Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 234-240. doi: 10.12290/xhyxzz.2022-0694
Citation: SHEN Tian, WU Xiaochuan. Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 234-240. doi: 10.12290/xhyxzz.2022-0694

Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies

doi: 10.12290/xhyxzz.2022-0694
Funds:

National Key Research and Development Program of China 2021YFC2702004

National Natural Science Foundation of China Youth Project 82101905

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  • Corresponding author: WU Xiaochuan, E-mail: xiaochuanwu@csu.edu.cn
  • Received Date: 2022-12-05
  • Accepted Date: 2023-03-02
  • Available Online: 2023-03-12
  • Publish Date: 2023-03-30
  • Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs or systems. The etiology of SLE is complex, involving molecular genetics, epigenetics, innate immunity, acquired immunity, race, hormone and environmental factors. Recent progress in fine immunophenotyping, GWAS, single cell sequencing and multiomics analysis has enabled a deeper understanding of the pathogenesis of SLE. Various monoclonal antibodies or small molecule drugs targeting immune cells, costimulatory molecules, cytokines or signal transduction pathways, and CART cell immunotherapy have been developed or even applied in clinical treatment. The approval of belizumab, telitacicept, anifrolumab and voclosporin for SLE has given clinicians, researchers and patients greater confidence and more treatment options for patients with moderate to severe SLE, especially those with refractory SLE.
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