Volume 14 Issue 5
Sep.  2023
Turn off MathJax
Article Contents
HUANG Biqing, LI Lanjuan. The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 939-944. doi: 10.12290/xhyxzz.2023-0173
Citation: HUANG Biqing, LI Lanjuan. The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 939-944. doi: 10.12290/xhyxzz.2023-0173

The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms

doi: 10.12290/xhyxzz.2023-0173
Funds:

CAMS Innovation Fund for Medical Sciences 2019-I2M- 5- 045

More Information
  • Corresponding author: LI Lanjuan, E-mail: ljli@zju.edu.cn
  • Received Date: 2023-04-03
  • Accepted Date: 2023-05-29
  • Available Online: 2023-06-01
  • Publish Date: 2023-09-30
  • Vaccine is the most effective method to prevent the spread of communicable diseases, but the immune response it induces varies significantly among individuals and populations in different regions. Recent studies have shown that the composition and function of the gut microbiota play a key role in the immune response following vaccination. This article aims to explain the differences in gut microbiota among different vaccinated populations and animals, discuss how the gut microbiota affects the immune efficacy of the vaccine, and summarize strategies for targeting the gut microbiota to improve vaccine efficacy.
  • loading
  • [1] Lynn DJ, Benson SC, Lynn MA, et al. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms[J]. Nat Rev Immunol, 2022, 22: 33-46. doi:  10.1038/s41577-021-00554-7
    [2] de Jong SE, Olin A, Pulendran B. The Impact of the Microbiome on Immunity to Vaccination in Humans[J]. Cell Host Microbe, 2020, 28: 169-179. doi:  10.1016/j.chom.2020.06.014
    [3] Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy[J]. Lancet Microbe, 2022, 3: e787-e794. doi:  10.1016/S2666-5247(22)00185-9
    [4] Swaminathan G, Citron M, Xiao J, et al. Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome[J]. Vaccines (Basel), 2021, 9: 1340. doi:  10.3390/vaccines9111340
    [5] Zhang Y, Wu Q, Zhou M, et al. Composition of the murine gut microbiome impacts humoral immunity induced by rabies vaccines[J]. Clin Transl Med, 2020, 10: e161. doi:  10.1002/ctm2.161
    [6] Harris VC, Armah G, Fuentes S, et al. Significant Correlation Between the Infant Gut Microbiome and Rotavirus Vaccine Response in Rural Ghana[J]. J Infect Dis, 2017, 215: 34-41. doi:  10.1093/infdis/jiw518
    [7] Harris V, Ali A, Fuentes S, et al. Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan[J]. Gut Microbes, 2018, 9: 93-101. doi:  10.1080/19490976.2017.1376162
    [8] Kim AH, Armah G, Dennis F, et al. Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants[J]. Cell Host Microbe, 2022, 30: 110-123. e115. doi:  10.1016/j.chom.2021.12.002
    [9] Fix J, Chandrashekhar K, Perez J, et al. Association between Gut Microbiome Composition and Rotavirus Vaccine Response among Nicaraguan Infants[J]. Am J Trop Med Hyg, 2020, 102: 213-219. doi:  10.4269/ajtmh.19-0355
    [10] Robertson RC, Church JA, Edens TJ, et al. The fecal microbiome and rotavirus vaccine immunogenicity in rural Zimbabwean infants[J]. Vaccine, 2021, 39: 5391-5400. doi:  10.1016/j.vaccine.2021.07.076
    [11] Huda MN, Ahmad SM, Alam MJ, et al. Bifidobacterium Abundance in Early Infancy and Vaccine Response at 2 Years of Age[J]. Pediatrics, 2019, 143: e20181489. doi:  10.1542/peds.2018-1489
    [12] Moroishi Y, Gui J, Nadeau KC, et al. A prospective study of the infant gut microbiome in relation to vaccine response[J]. Pediatr Res, 2023, 93: 725-731. doi:  10.1038/s41390-022-02154-0
    [13] Stražar M, Mourits VP, Koeken V, et al. The influence of the gut microbiome on BCG-induced trained immunity[J]. Genome Biol, 2021, 22: 275. doi:  10.1186/s13059-021-02482-0
    [14] Ng SC, Peng Y, Zhang L, et al. Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events[J]. Gut, 2022, 71: 1106-1116. doi:  10.1136/gutjnl-2021-326563
    [15] Alexander JL, Mullish BH, Danckert NP, et al. The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients[J]. EBioMedicine, 2023, 88: 104430. doi:  10.1016/j.ebiom.2022.104430
    [16] Seong H, Choi BK, Han YH, et al. Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines[J]. Signal Transduct Target Ther, 2023, 8: 178. doi:  10.1038/s41392-023-01445-0
    [17] Lynn MA, Tumes DJ, Choo JM, et al. Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice[J]. Cell Host Microbe, 2018, 23: 653-660. e655. doi:  10.1016/j.chom.2018.04.009
    [18] Yitbarek A, Astill J, Hodgins DC, et al. Commensal gut microbiota can modulate adaptive immune responses in chickens vaccinated with whole inactivated avian influenza virus subtype H9N2[J]. Vaccine, 2019, 37: 6640-6647. doi:  10.1016/j.vaccine.2019.09.046
    [19] Nadeem S, Maurya SK, Das DK, et al. Gut Dysbiosis Thwarts the Efficacy of Vaccine Against Mycobacterium tuberculosis[J]. Front Immunol, 2020, 11: 726. doi:  10.3389/fimmu.2020.00726
    [20] Parker EPK, Bronowski C, Sindhu KNC, et al. Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants[J]. Nat Commun, 2021, 12: 7288. doi:  10.1038/s41467-021-27074-1
    [21] Gonçalves JIB, Borges TJ, de Souza APD. Microbiota and the Response to Vaccines Against Respiratory Virus[J]. Front Immunol, 2022, 13: 889945. doi:  10.3389/fimmu.2022.889945
    [22] Oh JZ, Ravindran R, Chassaing B, et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination[J]. Immunity, 2014, 41: 478-492. doi:  10.1016/j.immuni.2014.08.009
    [23] Abt MC, Osborne LC, Monticelli LA, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity[J]. Immunity, 2012, 37: 158-170. doi:  10.1016/j.immuni.2012.04.011
    [24] Wang B, Zhang L, Wang Y, et al. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions[J]. Signal Transduct Target Ther, 2022, 7: 143. doi:  10.1038/s41392-022-00986-0
    [25] Silva F, Enaud R, Creissen E, et al. Mouse Subcutaneous BCG Vaccination and Mycobacterium tuberculosis Infection Alter the Lung and Gut Microbiota[J]. Microbiol Spectr, 2022, 10: e0169321. doi:  10.1128/spectrum.01693-21
    [26] Macpherson AJ. Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism[J]. Cold Spring Harb Perspect Biol, 2018, 10: a029363. doi:  10.1101/cshperspect.a029363
    [27] Littman DR. Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? If So, Is There Potential for Efficacious Microbiota-Based Vaccines?[J]. Cold Spring Harb Perspect Biol, 2018, 10: a029355. doi:  10.1101/cshperspect.a029355
    [28] Jia L, Weng S, Wu J, et al. Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity[J]. Gut Microbes, 2022, 14: 2117503. doi:  10.1080/19490976.2022.2117503
    [29] Yilmaz B, Portugal S, Tran TM, et al. Gut microbiota elicits a protective immune response against malaria transmission[J]. Cell, 2014, 159: 1277-1289. doi:  10.1016/j.cell.2014.10.053
    [30] Hagan T, Cortese M, Rouphael N, et al. Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans[J]. Cell, 2019, 178: 1313-1328. e1313. doi:  10.1016/j.cell.2019.08.010
    [31] Harris VC, Haak BW, Handley SA, et al. Effect of Antibiotic-Mediated Microbiome Modulation on Rotavirus Vaccine Immunogenicity: A Human, Randomized-Control Proof-of-Concept Trial[J]. Cell Host Microbe, 2018, 24: 197-207. e194. doi:  10.1016/j.chom.2018.07.005
    [32] Mullié C, Yazourh A, Thibault H, et al. Increased poliovirus-specific intestinal antibody response coincides with promotion of Bifidobacterium longum-infantis and Bifido-bacterium breve in infants: a randomized, double-blind, placebo-controlled trial[J]. Pediatr Res, 2004, 56: 791-795. doi:  10.1203/01.PDR.0000141955.47550.A0
    [33] Sandionigi A, De Giani A, Tursi F, et al. Effectiveness of Multistrain Probiotic Formulation on Common Infectious Disease Symptoms and Gut Microbiota Modulation in Flu-Vaccinated Healthy Elderly Subjects[J]. Biomed Res Int, 2022, 2022: 3860896.
    [34] Laver JR, Gbesemete D, Dale AP, et al. A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage[J]. Sci Transl Med, 2021, 13: eabe8573. doi:  10.1126/scitranslmed.abe8573
    [35] Taghinezhad SS, Keyvani H, Bermúdez-Humarán LG, et al. Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: an overview on the gut-vagina axis[J]. Cell Mol Life Sci, 2021, 78: 1191-1206. doi:  10.1007/s00018-020-03652-2
    [36] Lunken GR, Golding L, Schick A, et al. Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination[J]. Gut, 2022: gutjnl-2022-328556. doi:  10.1136/gutjnl-2022-328556
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Article Metrics

    Article views (1181) PDF downloads(59) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return