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Volume 11 Issue 5
Sep.  2020
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Yue-kun WANG, Peng-hao LIU, Yu WANG, Wen-bin MA. Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 606-614. DOI: 10.3969/j.issn.1674-9081.2020.05.018
Citation: Yue-kun WANG, Peng-hao LIU, Yu WANG, Wen-bin MA. Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 606-614. DOI: 10.3969/j.issn.1674-9081.2020.05.018
shu

Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor

  • Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    WANG Yu  Tel: 86-10-69152533, E-mail: ywang@pumch.cn

  • Received Date: June 18, 2018
  • Issue Publish Date: September 29, 2020
    Graphical Abstract
    • Abstract
  • Single-cell sequencing is characterized by precise analysis of genome, transcriptome, epigenomics, and multi-omics of cancer cells at the single-cell level, which promotes understanding of evolution and dynamic changes in cancer niches. Yet, intra- and extra-tumor heterogeneity of brain tumors can make it difficult to obtain a full-view landscape in bulky tumor assessment. Based on single-cell sequencing, genomic instability, biomarker, signaling pathway and immune responses in the tumor environment of a brain malignant tumor can be uncovered, which provides a novel opportunity for assessment, diagnosis, classification and management of brain malignant tumors. In this article, we review the progress of single-cell sequencing and the prospect in the management of brain malignant tumor in the future.
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