Changes in Postoperative Blood Glucose and the Predictive Factors in Patients with Pheochromocytoma Complicated with Type 2 Diabetes

  Objective  We aimed to observe the changes in postoperative blood glucose of patients with pheochromocytoma complicated with type 2 diabetes and explore the potential predictive factors for the postoperative remission of diabetes.

  Methods  Preoperative and follow-up information of patients with pheochromocytoma complicated with type 2 diabetes who underwent the surgery of radical resection in West China Hospital from January 2012 to December 2016 was retrospectively collected and analyzed. Analyzed variables included age, sex, body mass index (BMI), tumor diameter, preoperative blood catecholamine, preoperative and postoperative hypoglycemic regimen, and fasting blood glucose. Postoperative remission of diabetes was defined as discontinuing/reducing of hypoglycemic drugs or fasting blood glucose ≤ 6.1 mmol/L. According to with or without remission, the patients were divided into two groups:remission group and non-remission group. The predictive factors for remission were analyzed by single-variable Logistic regression analysis.

  Results  Twenty-seven patients with pheochromocytoma complicated with type 2 diabetes who had full follow-up data were enrolled in this study, including 8 males and 19 females, aged (51±9)years old. The postoperative fasting blood glucose was significantly lower than the preoperative one(5.14±1.37)mmol/L vs. (8.68±5.94)mmol/L, P < 0.01. The overall remission rate of postoperative diabetes was 78% (21/27) and the non-remission rate was 22%(6/27). Single-variable Logistic regression analysis showed that age, sex, BMI, tumor diameter, and preoperative plasma catecholamine were unrelated to the postoperative remission of diabetes.

  Conclusions  Radical resection for patients with pheochromocytoma complicated with type 2 diabetes could significantly improve diabetes after surgery. Age, sex, BMI, tumor diameter, and preoperative blood catecholamine are not the independent predictive factors for a postoperative remission of diabetes.