Diagnostic and Therapeutic Features of Bronchopulmonary Carcinoid

  Objective  The aim of this study was to evaluate the clinical features and the surgical experience of patients with bronchopulmonary carcinoids, including typical carcinoid (TC) and atypical carcinoid (ATC), and to analyze the potential prognostic factors.

  Methods  From January 2000 to January 2014, the clinical data of 57 consecutive cases of bronchopulmonary undergoing surgical resection and confirmed as TC or ATC by pathology in Peking Union Medical College Hospital were retrospectively analyzed; survival and prognostic analysis were also performed.

  Results  There were 35 males and 22 females. The median age was 49(12-85)years old, and the median duration of disease was 3(1-156)months. Clinical symptoms lack specificity, and 12 cases got ectopic adrenocorticotropic hormone syndrome. The postoperative pathological examination confirmed 39 cases of TC and 12 cases of ATC; staging consisted of 41 cases of stage Ⅰ, 7 stage Ⅱ, 7 stage Ⅲ, and 2 stage Ⅳ. The 5-year and the 10-year survival rates were 92.4% and 89.0%, respectively. Kaplan-Meier analysis showed that the P values of pathological type, T stage and N stage were 0.001, 0.000 and 0.004, respectively.

  Conclusions  The clinical features of bronchopulmonary TC and ATC are atypical and these patients have a preferably prognosis after surgery. Pathological types, T stages, and N stages might be the prognostic factors.