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Volume 15 Issue 2
Mar.  2024
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CHE Lu, YU Jiawen, JIN Di, BAI Xue, WANG Yi, ZHANG Yuelun, XU Li, SHEN Le, HUANG Yuguang. Chronic Postsurgical Pain Among Patients with Preoperative COVID-19: An Ambispective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 344-350. DOI: 10.12290/xhyxzz.2023-0556
Citation: CHE Lu, YU Jiawen, JIN Di, BAI Xue, WANG Yi, ZHANG Yuelun, XU Li, SHEN Le, HUANG Yuguang. Chronic Postsurgical Pain Among Patients with Preoperative COVID-19: An Ambispective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 344-350. DOI: 10.12290/xhyxzz.2023-0556
shu

Chronic Postsurgical Pain Among Patients with Preoperative COVID-19: An Ambispective Cohort Study

  • 1.

    Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National High-Level Hospital Clinical Research Funding 2022-PUMCH-B-007

More Information
  • Corresponding author:

    SHEN Le, E-mail: pumchshenle@163.com

  • Received Date: November 20, 2023
  • Accepted Date: November 28, 2023
  • Available Online: February 25, 2024
  • Issue Publish Date: March 29, 2024
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the occurrence of chronic postsurgical pain (CPSP) among patients with preoperative COVID-19, and further analyze the risk factors for CPSP.
      Methods  This study was a ambispective cohort study, with subjects from a completed cohort study with follow-up. We included the clinical data of the patients with preoperative COVID-19 who underwent surgery at Peking Union Medical College Hospital from December 1, 2022 to February 28, 2023. Follow-up was conducted up to 6 months postoperatively, with the primary outcome being CPSP. Multivariate Logistic regression analysis was used to analyze the correlation between COVID-19-related exposure indicators and CPSP.
      Results  A total of 4117 surgical patients were included, all of whom had preoperative COVID-19. Among them, 4002 cases had mild symptoms during the acute phase, 62 cases had severe symptoms, and 53 cases were critically ill. At 6th month postoperatively, 1298 cases (31.53%) had long COVID-19 syndrome, and the incidence of CPSP was 5.59% (95% CI: 4.88%-6.28%). After adjusting for confounding factors including age, gender, comorbidities, anesthesia method, and type of surgery, multivariate Logistic regression analysis revealed that critically ill COVID-19 during the acute phase (aOR=3.35, 95% CI: 1.48-7.62, P < 0.001) and presence of long COVID-19 syndrome postoperatively (aOR=2.50, 95% CI: 1.90-3.29, P < 0.001) were associated with CPSP.
      Conclusions  It is clear for the first time that critically ill COVID-19 during the acute phase and the presence of long COVID-19 syndrome postoperatively are the risk factors for CPSP among patients with preoperative COVID-19.
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    • References (32)
  • [1]
    COVID-19 rapid guideline: managing the long-term effects of COVID-19[M]. London: National Institute for Health and Care Excellence (NICE), 2020.
    [2]
    Soriano J B, Murthy S, Marshall J C, et al. A clinical case definition of post-COVID-19 condition by a Delphi consensus[J]. Lancet Infect Dis, 2022, 22(4): e102-e107. DOI: 10.1016/S1473-3099(21)00703-9
    [3]
    Soares F H C, Kubota G T, Fernandes A M, et al. Prevalence and characteristics of new-onset pain in COVID-19 survivours, a controlled study[J]. Eur J Pain, 2021, 25(6): 1342-1354. DOI: 10.1002/ejp.1755
    [4]
    Zis P, Ioannou C, Artemiadis A, et al. Prevalence and determinants of chronic pain post-COVID; cross-sectional study[J]. J Clin Med, 2022, 11(19): 5569. DOI: 10.3390/jcm11195569
    [5]
    Kemp H I, Corner E, Colvin L A. Chronic pain after COVID-19: implications for rehabilitation[J]. Br J Anaesth, 2020, 125(4): 436-440. DOI: 10.1016/j.bja.2020.05.021
    [6]
    Oronsky B, Larson C, Hammond T C, et al. A review of persistent post-COVID syndrome (PPCS)[J]. Clin Rev Allergy Immunol, 2023, 64(1): 66-74.
    [7]
    Su S, Cui H, Wang T, et al. Pain: a potential new label of COVID-19[J]. Brain Behav Immun, 2020, 87: 159-160. DOI: 10.1016/j.bbi.2020.05.025
    [8]
    Che L, Yu J W, Bai X, et al. Association between post-COVID-19 status and perioperative morbidity and mortality: protocol for an ambispective cohort study[J]. BMJ Open, 2023, 13(9): e074337. DOI: 10.1136/bmjopen-2023-074337
    [9]
    北京协和医院新型冠状病毒感染诊疗多学科专家组. 北京协和医院成人新型冠状病毒感染实用诊疗建议(2023)[J]. 协和医学杂志, 2023, 14(1): 50-59. DOI: 10.12290/xhyxzz.2023-0003

    Multi-Disciplinary Expert Team for COVID-19, Peking Union Medical College Hospital. Diagnosis and clinical management of COVID-19 infection in adults: operational recommendations of Peking Union Medical College Hospital (2023)[J]. Med J PUMCH, 2023, 14(1): 50-59. DOI: 10.12290/xhyxzz.2023-0003
    [10]
    Schug S A, Bruce J. Risk stratification for the development of chronic postsurgical pain[J]. Pain Rep, 2017, 2(6): e627. DOI: 10.1097/PR9.0000000000000627
    [11]
    Fletcher D, Stamer U M, Pogatzki-Zahn E, et al. Chronic postsurgical pain in Europe: an observational study[J]. Eur J Anaesthesiol, 2015, 32(10): 725-734. DOI: 10.1097/EJA.0000000000000319
    [12]
    Mandal S, Barnett J, Brill S E, et al. 'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19[J]. Thorax, 2021, 76(4): 396-398. DOI: 10.1136/thoraxjnl-2020-215818
    [13]
    Romeiser J L, Morley C P, Singh S M. COVID-19 symptom load as a risk factor for chronic pain: a national cross-sectional study[J]. PLoS One, 2023, 18(6): e0287554. DOI: 10.1371/journal.pone.0287554
    [14]
    Van Driel M E C, Van Dijk J F M, Baart S J, et al. Development and validation of a multivariable prediction model for early prediction of chronic postsurgical pain in adults: a prospective cohort study[J]. Br J Anaesth, 2022, 129(3): 407-415. DOI: 10.1016/j.bja.2022.04.030
    [15]
    Richebé P, Capdevila X, Rivat C. Persistent postsurgical pain: pathophysiology and preventative pharmacologic considerations[J]. Anesthesiology, 2018, 129(3): 590-607. DOI: 10.1097/ALN.0000000000002238
    [16]
    Monje M, Iwasaki A. The neurobiology of long COVID[J]. Neuron, 2022, 110(21): 3484-3496. DOI: 10.1016/j.neuron.2022.10.006
    [17]
    Koc H C, Xiao J, Liu W W, et al. Long COVID and its Management[J]. Int J Biol Sci, 2022, 18(12): 4768-4780. DOI: 10.7150/ijbs.75056
    [18]
    Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection[J]. N Engl J Med, 2020, 382(23): 2268-2270. DOI: 10.1056/NEJMc2008597
    [19]
    Iadecola C, Anrather J, Kamel H. Effects of COVID-19 on the nervous system[J]. Cell, 2020, 183(1): 16-27.e1. DOI: 10.1016/j.cell.2020.08.028
    [20]
    Fernández-De-Las-Peñas C, Navarro-Santana M, Plaza-Manzano G, et al. Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: a systematic review and meta-analysis[J]. Pain, 2022, 163(7): 1220-1231. DOI: 10.1097/j.pain.0000000000002496
    [21]
    Jackson C B, Farzan M, Chen B, et al. Mechanisms of SARS-CoV-2 entry into cells[J]. Nat Rev Mol Cell Biol, 2022, 23(1): 3-20.
    [22]
    Fernández-De-Las-Peñas C, Nijs J, Neblett R, et al. Phenotyping post-COVID pain as a nociceptive, neuropathic, or nociplastic pain condition[J]. Biomedicines, 2022, 10(10): 2562. DOI: 10.3390/biomedicines10102562
    [23]
    Pierce J D, Shen Q H, Cintron S A, et al. Post-COVID-19 syndrome[J]. Nurs Res, 2022, 71(2): 164-174. DOI: 10.1097/NNR.0000000000000565
    [24]
    王晴, 钱捷, 黄蔷如, 等. 新型冠状病毒再感染的流行病学特征概述[J]. 中华医学杂志, 2023, 103(12): 934-938. https://www.cnki.com.cn/Article/CJFDTOTAL-CRBX202305011.htm

    Wang Q, Qian J, Huang Q R, et al. Epidemiological characteristics of novel coronavirus reinfection[J]. Natl Med J Chin, 2023, 103(12): 934-938. https://www.cnki.com.cn/Article/CJFDTOTAL-CRBX202305011.htm
    [25]
    孙泽宇, 柴佳彤, 许建成. 新冠病毒变异株"奥密克戎" 的研究进展[J]. 病毒学报, 2023, 39(2): 517-527. https://www.cnki.com.cn/Article/CJFDTOTAL-BDXB202302025.htm

    Sun Z Y, Chai J T, Xu J C. Research progress on the omicron variant of SARS-CoV-2[J]. Chin J Virol, 2023, 39(2): 517-527. https://www.cnki.com.cn/Article/CJFDTOTAL-BDXB202302025.htm
    [26]
    Raman B, Bluemke D A, Lüscher T F, et al. Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus[J]. Eur Heart J, 2022, 43(11): 1157-1172. DOI: 10.1093/eurheartj/ehac031
    [27]
    Thompson E J, Williams D M, Walker A J, et al. Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records[J]. Nat Commun, 2022, 13(1): 3528. DOI: 10.1038/s41467-022-30836-0
    [28]
    Sudre C H, Murray B, Varsavsky T, et al. Attributes and predictors of long COVID[J]. Nat Med, 2021, 27(4): 626-631. DOI: 10.1038/s41591-021-01292-y
    [29]
    Du Z W, Wang Y C, Bai Y, et al. Estimate of COVID-19 deaths, China, December 2022-February 2023[J]. Emerg Infect Dis, 2023, 29(10): 2121-2124.
    [30]
    Cai J P, Lin K, Zhang H C, et al. A one-year follow-up study of systematic impact of long COVID symptoms among patients post SARS-CoV-2 omicron variants infection in Shanghai, China[J]. Emerg Microbes Infect, 2023, 12(2): 2220578. DOI: 10.1080/22221751.2023.2220578
    [31]
    申乐, 黄宇光. 术后疼痛管理的发展与变革[J]. 中国科学: 生命科学, 2021, 51(8): 957-962. https://www.cnki.com.cn/Article/CJFDTOTAL-JCXK202108011.htm

    Shen L, Huang Y G. Postoperative pain management: past, present and future[J]. Sci Sin Vitae, 2021, 51(8): 957-962. https://www.cnki.com.cn/Article/CJFDTOTAL-JCXK202108011.htm
    [32]
    Al-Aly Z, Xie Y, Bowe B. High-dimensional characteriza-tion of post-acute sequelae of COVID-19[J]. Nature, 2021, 594(7862): 259-264. DOI: 10.1038/s41586-021-03553-9
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