Intraoperative Intravenous Lidocaine Infusion Optimized Postoperative Pain Control and Enhanced Recovery of Gastrointestinal Function after Surgery: A Retrospective Cohort Study

  Objective  The aim of this study was to investigate the effect of intraoperative intravenous lidocaine infusion on pain control and the recovery of gastrointestinal function after abdominal pelvic surgery.

  Methods  Clinical data of patients who underwent abdominal pelvic surgery under general anesthesia from January 2017 to May 2019 in Peking Union Medical College Hospital were retrospectively collected and analyzed. The patients of the control group received traditional general anesthesia, while those of the experimental group received the intravenous infusion of lidocaine based on general anesthesia. The total amount of sufentanil within the postoperative 24 h, pain visual analogue score (VAS), the number of deliveries, incidence of nausea andvomiting, the propertion of patients with intestinal passing gas were compared.

  Results  The amount of sufentanil and the number of deliveries in the experimental group were lower than those in the control group(0.0372±0.0137)μg/(kg·h) vs. (0.0498±0.0447)μg/(kg·h), t=-2.190, P=0.030; 7.4±6.7 vs. 11.1±10.6, t=-2.257, P=0.027. Compared with that in the control group, the proportion of the pain VAS ≤ 3 at rest and active state in the experimental group were higher(97.0% vs. 85.5%, χ²=3.938, P=0.047; 68.7% vs. 47.3%, χ²=5.710, P=0.017), as well as the proportion of patients with intestinal passing gas(26.9% vs. 5.5%, χ²=9.717, P=0.002); there was no statistical difference in the incidence of nausea and vomiting.

  Conclusion  Intraoperative intravenous lidocaine infusion may be helpful to optimize postoperative pain control and enhance the recovery of gastrointestinal function after surgery.