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Volume 15 Issue 1
Jan.  2024
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QI Xin, ZHANG Xiaogang, YU Haiyang, CHEN Xin, AN Wenbo, WANG Zhipeng, WANG Duoxian, LUO Pengfei, CHEN Yixin, MA Jiaojiao, QI Wei, HU Ziyang, LIU Jianjun. Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 141-146. DOI: 10.12290/xhyxzz.2023-0269
Citation: QI Xin, ZHANG Xiaogang, YU Haiyang, CHEN Xin, AN Wenbo, WANG Zhipeng, WANG Duoxian, LUO Pengfei, CHEN Yixin, MA Jiaojiao, QI Wei, HU Ziyang, LIU Jianjun. Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 141-146. DOI: 10.12290/xhyxzz.2023-0269
shu

Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes

  • 1.

    Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

  • 2.

    Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Funds: 

Zhang Xiaogang National Famous Traditional Chinese Medicine Expert Inheritance Studio Construction Project National Traditional Chinese Medicine Human Education Letter[2022] No. 75

2021 Health Industry Scientific research project GSWSKY-2021-069

Gansu University of Traditional Chinese Medicine Graduate Student Innovation and Entre-preneurship Project 

More Information
  • Corresponding author:

    LIU Jianjun, E-mail: g.sljj@163.com

  • Received Date: June 04, 2023
  • Accepted Date: August 10, 2023
  • Available Online: November 19, 2023
  • Issue Publish Date: January 29, 2024
    Graphical Abstract
    • Abstract
  • Osteoarthritis (OA) is a chronic degenerative joint disease whose main characteristic is the destruction of articular cartilage, causing pain and disability in patients and seriously affecting their quality of life. OA can be induced by a variety of causes, and pathological changes in articular cartilage are considered to be one of the key driving factors for the occurrence of OA. High mobility group box-1 protein (HMGB1), as a non-histone protein in eukaryotic cells, can participate in regulating the inflammation and apoptosis process of OA chondrocytes, thus leading to the occurrence of OA. This article reviews the research on the mechanism of HMGB1 in OA chondrocytes, with a view to providing new ideas for the clinical prevention and treatment of OA.
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    • References (43)
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