Mechanism of Bacterial Extracellular Vesicles in Disease Development and Prospects for Application

LUO Xiaoxia; QIN Sihua; WANG Huidi; ZHOU Hongwei; HE Yan

doi:10.12290/xhyxzz.2023-0260

Volume 14 Issue 5

Sep. 2023

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Medical Journal of Peking Union Medical College Hospital > 2023 > 14(5): 915-924. > DOI: 10.12290/xhyxzz.2023-0260

LUO Xiaoxia, QIN Sihua, WANG Huidi, ZHOU Hongwei, HE Yan. Mechanism of Bacterial Extracellular Vesicles in Disease Development and Prospects for Application[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 915-924. DOI: 10.12290/xhyxzz.2023-0260

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Mechanism of Bacterial Extracellular Vesicles in Disease Development and Prospects for Application

LUO Xiaoxia¹,
QIN Sihua¹,
WANG Huidi¹,
ZHOU Hongwei^{1, 2, 3},
HE Yan^{1, 2, 3, ,}

1.
Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China
2.
State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou 510000, China
3.
Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou 510000, China

Funds:

National Natural Science Foundation of China 82272391

National Natural Science Foundation of China 82022044

More Information

Corresponding author:
HE Yan, E-mail: bioyanhe@gmail.com
Received Date: May 30, 2023
Accepted Date: June 26, 2023
Available Online: July 11, 2023
Issue Publish Date: September 29, 2023

Graphical Abstract

Abstract

Abstract

Bacterial extracellular vesicles (BEVs), bacteria-derived extracellular vesicles, are key intermediates of bacteria-bacteria and bacteria-host interactions. They are a "double-edged sword". On one hand, they play a negative role in the onset and progression of various diseases, including intestinal inflammatory disease, neurological disease, liver disease, metabolic disease, autoimmune disease and cancer. On the other hand, they play a positive role as potential biomarkers, vaccines, antitumor agents. The application of BEVs may provide novel strategies for the diagnosis and treatment of diseases. However, research on BEVs is still in its infancy, and challenges remain in vesicle isolation techniques, disease diagnostic specificity, optimization of vesicle storage and transport. Thus rigorously designed clinical studies are required to verify their diagnostic and therapeutic value.
- bacterial extracellular vesicles,
- diseases,
- biomarkers,
- vaccines,
- probiotics,
- antitumor agents

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References

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