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WEI Xiaonan, YANG Yiqiong, CAI Yahui, GUO Chaoqiang, LI Yanping. Antitumor Effect of Resveratrol: Mechanism and Research Progress[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0302
Citation: WEI Xiaonan, YANG Yiqiong, CAI Yahui, GUO Chaoqiang, LI Yanping. Antitumor Effect of Resveratrol: Mechanism and Research Progress[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0302
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Antitumor Effect of Resveratrol: Mechanism and Research Progress

  • 1 Precision Medicine Laboratory for Chronic Non-communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical University, Jining 272067, China;

  • 2 School of Clinical Medicine, Jining Medical University, Jining 272067, China

Funds: 

Youth Fund Project of National Natural Science Foundation of China(82002961)

Undergraduate Innovation Training Program Project of Jining Medical University (cx2023141z)

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  • Received Date: May 08, 2024
  • Accepted Date: June 02, 2024
  • Available Online: December 26, 2024
    Graphical Abstract
    • Abstract
  • Resveratrol, a natural polyphenolic compound widely found in a variety of plants such as grapes, apples, blueberries, plums and peanuts, has been widely studied for its multiple biological functions such as its antioxidant, anti-inflammatory, antiviral, neuroprotective, cardioprotective, immunomodulatory and antitumor effects. This review aims to analyze the pleiotropic antitumor effects of resveratrol, including inhibition of tumor cell proliferation and metastasis, promotion of tumor cell autophagy, improvement of the tumor microenvironment, reduction of tumor cell resistance, and induction of epigenetic modifications. The research progress of resveratrol in colorectal, breast, lung, cervical, prostate, and oral cancers is also summarized. With its wide range of anti-tumor activities, resveratrol is expected to be a potential drug for tumor prevention and treatment.
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    • References (59)
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