Citation: | Multi-disciplinary Expert Team for COVID-19, Peking Union Medical College Hospital. Diagnosis and Clinical Management of COVID-19 Infection in Adults: Operational Recommendations of Peking Union Medical College Hospital (2023)[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 50-59. DOI: 10.12290/xhyxzz.2023-0003 |
[1] |
国务院联防联控机制综合组. 新型冠状病毒感染诊疗方案(试行第十版)[EB/OL]. (2023-01-06) [2023-01-06]. http://www.nhc.gov.cn/ylyjs/pqt/202301/32de5b2ff9bf4eaa88e75bdf7223a65a/files/460b0e7b19bd42f3bba00c1efb9b6811.pdf.
|
[2] |
WHO. Therapeutics and COVID-19: living guideline[EB/OL]. (2022-07-14)[2023-01-03]. https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2022.4.
|
[3] |
Singh AP, Finkelstein M, Chung M, et al. Review of Thoracic Imaging Manifestations of COVID-19 Coronaviruses and Other Pathologic [J]. Radiol Clin North Am, 2022, 60: 359-369. DOI: 10.1016/j.rcl.2022.01.004
|
[4] |
CDC. Risk for COVID-19 infection, hospitalization, and death by age group[EB/OL]. (2022-12-28)[2023-01-03]. https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-age.html.
|
[5] |
Fisman DN, Bogoch I, Lapointe-Shaw L, et al. Risk factors associated with mortality among residents with coronavirus disease 2019 (COVID-19) in long-term care facilities in Ontario, Canada [J]. JAMA Netw Open, 2020, 3: e2015957-e. DOI: 10.1001/jamanetworkopen.2020.15957
|
[6] |
Suthar AB, Wang J, Seffren V, et al. Public health impact of covid-19 vaccines in the US: observational study [J]. BMJ, 2022, 377: e069317.
|
[7] |
Stokes EK, Zambrano LD, Anderson KN, et al. Coronavirus disease 2019 case surveillance-United States, January 22-May 30, 2020 [J]. MMWR Morb Mortal Wkly Rep, 2020, 69: 759. DOI: 10.15585/mmwr.mm6924e2
|
[8] |
Lighter J, Phillips M, Hochman S, et al. Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission [J]. Clin Infect Dis, 2020, 71: 896-897. DOI: 10.1093/cid/ciaa415
|
[9] |
Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area [J]. JAMA, 2020, 323: 2052-2059. DOI: 10.1001/jama.2020.6775
|
[10] |
Goldman JD, Robinson PC, Uldrick TS, et al. COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies [J]. J Immunother Cancer, 2021, 9: e002630. DOI: 10.1136/jitc-2021-002630
|
[11] |
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [J]. JAMA, 2020, 323: 1061-1069. DOI: 10.1001/jama.2020.1585
|
[12] |
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J]. Lancet, 2020, 395: 1054-1062. DOI: 10.1016/S0140-6736(20)30566-3
|
[13] |
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J]. Lancet, 2020, 395: 507-513. DOI: 10.1016/S0140-6736(20)30211-7
|
[14] |
Rubin GD, Ryerson CJ, Haramati LB, et al. The role of chest imaging in patient management during the COVID-19 pandemic: a multinational consensus statement from the Fleischner Society [J]. Radiology, 2020, 296: 172-180. DOI: 10.1148/radiol.2020201365
|
[15] |
NIH. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines[EB/OL]. (2022-12-06)[2023-01-03]. https://www.ncbi.nlm.nih.gov/books/NBK570371/.
|
[16] |
Bradley MC, Perez-Vilar S, Chillarige Y, et al. Systemic Corticosteroid Use for COVID-19 in US Outpatient Settings From April 2020 to August 2021 [J]. JAMA, 2022, 327: 2015-2018. DOI: 10.1001/jama.2022.4877
|
[17] |
EUA HOEUA. Fact Sheet for Healthcare Providers: Emergency Use Authorization for EvusheldTM(Tixagevimab Co-Packaged with Cilgavimab)[EB/OL]. (2022-12)[2023-01-03]. https://www.fda.gov/media/154701/download.
|
[18] |
Food UATJL, Cooperative PA. Evidence used to update the list of underlying medical conditions that increase a person's risk of severe illness from COVID-19[EB/OL]. (2022-12)[2023-01-03]. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/evidence-table.html.
|
[19] |
Hiremath S, McGuinty M, Argyropoulos C, et al. Prescrib-ing nirmatrelvir/ritonavir for COVID-19 in advanced CKD [J]. Clin J Am Soc Nephrol, 2022, 17: 1247-1250. DOI: 10.2215/CJN.05270522
|
[20] |
辉瑞公司. PAXLOVID(奈玛特韦/利托那韦)—经肠内饲管给药[Z]. 2022.
|
[21] |
卫生健康委办公厅, 中医药局办公室. 关于将阿兹夫定片纳入新型冠状病毒肺炎诊疗方案的通知[EB/OL]. (2022-08-09)[2023-01-03]. http://www.gov.cn/zhengce/zhengceku/2022-08/10/content_5704788.htm.
|
[22] |
Agarwal A, Rochwerg B, Lamontagne F, et al. A living WHO guideline on drugs for covid-19 [J]. BMJ, 2020, 370: n2219.
|
[23] |
Chu VT, Schwartz NG, Donnelly MAP, et al. Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection [J]. JAMA Intern Med, 2022, 182: 701-709. DOI: 10.1001/jamainternmed.2022.1827
|
[24] |
White H, McDonald SJ, Barber B, et al. Care for adults with COVID-19: living guidelines from the National COVID-19 Clinical Evidence Taskforce [J]. Med J Aust, 2022, 217: 368-378. DOI: 10.5694/mja2.51718
|
[25] |
Mohammadi M, Khafaee Pour Khamseh A, Varpaei HA. Invasive Airway "Intubation" in COVID-19 Patients; Statistics, Causes, and Recommendations: A Review Article [J]. Anesth Pain Med, 2021, 11: e115868.
|
[26] |
El-Boghdadly K, Wong DJN, Owen R, et al. Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study [J]. Anaesthesia, 2020, 75: 1437-1447. DOI: 10.1111/anae.15170
|
[27] |
Camous L, Pommier JD, Martino F, et al. Very late intubation in COVID-19 patients: a forgotten prognosis factor? [J]. Crit Care, 2022, 26: 1-4. DOI: 10.1186/s13054-021-03885-y
|
[28] |
Ospina-Tascon GA, Calderón-Tapia LE, Garcia AF, et al. Effect of high-flow oxygen therapy vs conventional oxygen therapy on invasive mechanical ventilation and clinical recovery in patients with severe COVID-19: a randomized clinical trial [J]. JAMA, 2021, 326: 2161-2171. DOI: 10.1001/jama.2021.20714
|
[29] |
Frat JP, Thille AW, Mercat A, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure [J]. N Engl J Med, 2015, 372: 2185-2196. DOI: 10.1056/NEJMoa1503326
|
[30] |
Bellani G, Laffey JG, Pham T, et al. Noninvasive ventila-tion of patients with acute respiratory distress syndrome. Insights from the LUNG SAFE study [J]. Am J Respir Crit Care Med, 2017, 195: 67-77. DOI: 10.1164/rccm.201606-1306OC
|
[31] |
Ding L, Wang L, Ma W, et al. Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study [J]. Crit Care, 2020, 24: 1-8. DOI: 10.1186/s13054-019-2683-3
|
[32] |
Thompson AE, Ranard BL, Wei Y, et al. Prone positioning in awake, nonintubated patients with COVID-19 hypoxemic respiratory failure [J]. JAMA Intern Med, 2020, 180: 1537-1539. DOI: 10.1001/jamainternmed.2020.3030
|
[33] |
Weiss TT, Cerda F, Scott JB, et al. Prone positioning for patients intubated for severe acute respiratory distress syndrome (ARDS) secondary to COVID-19: a retrospective observational cohort study [J]. Br J Anaesth, 2021, 126: 48-55. DOI: 10.1016/j.bja.2020.09.042
|
[34] |
Horby P, Lim WS, Emberson JR, et al. Dexamethasone in Hospitalized Patients with COVID-19 [J]. N Engl J Med, 2021, 384: 693-704. DOI: 10.1056/NEJMoa2021436
|
[35] |
NHS. Interleukin-6 inhibitors (tocilizumab or sarilumab) for hospitalised patients with COVID-19 pneumonia (adults) [EB/OL]. (2021-02-17)[2023-01-03]. https://www.cas.mhra.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=103144.
|
[36] |
Kramer A, Prinz C, Fichtner F, et al. Janus kinase inhibitors for the treatment of COVID-19 [J]. Cochrane Database Syst Rev, 2022, 6: CD015209.
|
[37] |
Gordon AC, Mouncey PR, Al-Beidh F, et al. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 [J]. N Engl J Med, 2021, 384: 1491-1502. DOI: 10.1056/NEJMoa2100433
|
[38] |
Schiff MH, Kremer JM, Jahreis A, et al. Integrated safety in tocilizumab clinical trials [J]. Arthritis Res Ther, 2011, 13: 1-13.
|
[39] |
Guimarães PO, Quirk D, Furtado RH, et al. Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia [J]. N Engl J Med, 2021, 385: 406-415. DOI: 10.1056/NEJMoa2101643
|
[40] |
Han MK, Antila M, Ficker JH, et al. Ruxolitinib in addition to standard of care for the treatment of patients admitted to hospital with COVID-19 (RUXCOVID): a randomised, double-blind, placebo-controlled, phase 3 trial [J]. Lancet Rheumatol, 2022, 4: e351-e361. DOI: 10.1016/S2665-9913(22)00044-3
|
[41] |
Lansbury L, Lim B, Baskaran V, et al. Co-infections in people with COVID-19: a systematic review and meta-analysis [J]. J Infect, 2020, 81: 266-275. DOI: 10.1016/j.jinf.2020.05.046
|
[42] |
Thachil J, Tang N, Gando S, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19 [J]. J Thromb Haemost, 2020, 18: 1023-1026. DOI: 10.1111/jth.14810
|
[43] |
Sullivan DJ, Gebo KA, Shoham S, et al. Early Outpatient Treatment for Covid-19 with Convalescent Plasma [J]. N Engl J Med, 2022, 386: 1700-1711. DOI: 10.1056/NEJMoa2119657
|
[44] |
Nates JL, Nunnally M, Kleinpell R, et al. ICU Admission, Discharge, and Triage Guidelines: A Framework to Enhance Clinical Operations, Development of Institutional Policies, and Further Research [J]. Crit Care Med, 2016, 44: 1553-1602. DOI: 10.1097/CCM.0000000000001856
|
[45] |
Poon LC, Yang H, Dumont S, et al. ISUOG Interim Guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium: information for healthcare professionals-an update [J]. Ultrasound Obstet Gynecol, 2020, 55: 848. DOI: 10.1002/uog.22061
|
[46] |
Pfizer Lab. Fact sheet for healthcare providers: emergency use authorization for paxlovid[EB/OL]. (2022-03-18) [2023-01-03]. https://www.fda.gov/media/155050/down-load.
|
[47] |
McCreary EK, Lemon L, Megli C, et al. Monoclonal Antibodies for Treatment of SARS-CoV-2 Infection During Pregnancy: A Cohort Study [J]. Ann Intern Med, 2022, 175: 1707-1715. DOI: 10.7326/M22-1329
|
[48] |
Kabinger F, Stiller C, Schmitzová J, et al. Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis [J]. Nat Struct Mol Biol, 2021, 28: 740-746. DOI: 10.1038/s41594-021-00651-0
|
[49] |
CDC. Interim infection prevention and control recommendations for healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic[EB/OL]. (2022-09-23)[2023-01-03]. https://www.cdc.gov/coronavirus/2019-ncov/hcp/infection-control-recommendations.html.
|
[50] |
Zhang M, Zheng H, Wang J. Strategy of using personal protective equipment during aerosol generating medical procedures with COVID-19 [J]. J Clin Anesth, 2020, 66: 109911. DOI: 10.1016/j.jclinane.2020.109911
|
[51] |
Hong K, Cao W, Liu Z, et al. Prolonged presence of viral nucleic acid in clinically recovered COVID-19 patients was not associated with effective infectiousness [J]. Emerg Microbes Infect, 2020, 9: 2315-2321. DOI: 10.1080/22221751.2020.1827983
|
[52] |
Kim MC, Cui C, Shin KR, et al. Duration of culturable SARS-CoV-2 in hospitalized patients with Covid-19 [J]. N Engl J Med, 2021, 384: 671-673. DOI: 10.1056/NEJMc2027040
|
[53] |
Yahav D, Yelin D, Eckerle I, et al. Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity [J]. Clin Microbiol Infect, 2021, 27: 315-318. DOI: 10.1016/j.cmi.2020.11.028
|
[54] |
Abu-Raddad LJ, Chemaitelly H, Bertollini R. Severity of SARS-CoV-2 reinfections as compared with primary infections [J]. N Engl J Med, 2021, 385: 2487-2489. DOI: 10.1056/NEJMc2108120
|
[55] |
CDC. Interim Clinical Considerations for Use of COVID-19 Vaccines: Appendices, References, and Previous Updates[EB/OL]. (2022-12-09)[2023-01-03]. https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us-appendix.html.
|
[56] |
CDC. Ending Isolation and Precautions for People with COVID-19: Interim Guidance[EB/OL]. (2022-08-31)[2023-01-03]. https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html.
|
[1] | XU Kexin, LI Guozhuang, WU Zhihong, ZHANG Jianguo, DISCO(Deciphering Disorders Involving Scoliosis & Comorbidities) Study Group, WU Nan. Progress in Clinical Diagnosis and Management of Short Stature in Ehlers-Danlos Syndromes[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(1): 163-170. DOI: 10.12290/xhyxzz.2024-0173 |
[2] | CHEN Yuan, XU Qiang, WANG Weibin, ZHANG Taiping, GUO Junchao. Multidisciplinary Treatment of Pancreatic Cancer: Development and Experience of PUMCH[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 758-763. DOI: 10.12290/xhyxzz.2024-0281 |
[3] | LIU Wanrong, TANG Hui, ZHOU Na, QIU Wei, LI Xiaoyuan, WANG Xiang, BAI Chunmei, ZHOU Jianfeng, ZHAO Lin. Incidence of COVID-19 in Patients with Tumor During the Omicron Pandemic[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1238-1245. DOI: 10.12290/xhyxzz.2023-0281 |
[4] | SHI Yixin, WANG Yuekun, XING Hao, CHEN Wenlin, LIU Delin, ZHAO Binghao, YANG Tianrui, NIU Pei, WANG Yu, MA Wenbin. Diagnosis and Treatment Experience of Multidisciplinary Team for Brain Metastasis in Peking Union Medical College Hospital: A Summary of 159 Cases[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 306-314. DOI: 10.12290/xhyxzz.2022-0268 |
[5] | Multi-disciplinary Expert Team for Primary Care COVID-19 Practice, Peking Union Medical College Hospital. Practical Recommendations of Peking Union Medical College Hospital for Assessment and Management of COVID-19 in Primary Care (2023)[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 60-74. DOI: 10.12290/xhyxzz.2023-0014 |
[6] | LIU Yuan, ZHAO Lin. Update and Interpretation of 2022 National Comprehensive Cancer Network Clinical Practice Guidelines for Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 999-1004. DOI: 10.12290/xhyxzz.2022-0271 |
[7] | Rare Diseases Society of Chinese Research Hospital Association, National Rare Diseases Committee, Beijing Rare Disease Diagnosis, Treatment and Protection Society, Gitelman Syndrome Consensus Working Group. Expert Consensus for the Diagnosis and Treatment of Gitelman Syndrome in China (2021)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(6): 902-912. DOI: 10.12290/xhyxzz.2021-0555 |
[8] | Multidisciplinary Team for Rare Diseases, Peking Union Medical College Hospital. Consensus of Gaucher Disease by Experts from Multidisciplinary Team(2020)[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(6): 682-697. DOI: 10.3969/j.issn.1674-9081.2020.06.010 |
[9] | Xi BAI, Hui-juan ZHU, Hui PAN. The Multidisciplinary Pituitary Team of Peking Union Medical College Hospital: 40 Years of Hard Work[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 334-338. DOI: 10.3969/j.issn.1674-9081.20200060 |
[10] | Hao SUN, Gu-mu-yang ZHANG, Li-li XU, Zheng-yu JIN. The Value of Radiologist in the New Era's Multidisciplinary Team[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(1): 63-67. DOI: 10.3969/j.issn.1674-9081.2019.01.009 |
1. |
车璐,余佳文,金迪,白雪,王怡,张越伦,许力,申乐,黄宇光. 术前新型冠状病毒感染患者慢性术后疼痛发生率及其危险因素分析:一项双向队列研究. 协和医学杂志. 2024(02): 344-350 .
![]() | |
2. |
孙雅,彭定江,张艺军. 糖皮质激素治疗中型新型冠状病毒感染高龄老年患者62例临床疗效回顾性研究. 中国感染控制杂志. 2024(06): 680-686 .
![]() | |
3. |
王佳妮,赵妹,张辰,徐宁,徐安然,吴荣. 俯卧位通气在心血管外科开胸术后患者低氧血症中应用的研究进展. 当代护士(下旬刊). 2024(09): 28-31 .
![]() | |
4. |
中华医学会内分泌学分会,中国内分泌代谢病专科联盟. 糖皮质激素类药物临床应用指导原则(2023版). 中华内分泌代谢杂志. 2023(04): 289-296 .
![]() | |
5. |
郑文婷,张占杰,张杰石,彭华,周炯,马小军. 新冠疫情防控新20条政策实施后应急救治管理探索. 中国医疗管理科学. 2023(03): 106-110 .
![]() | |
6. |
袁兆丰,王海平,环大维,邱越,张超,夏天卫,沈计荣. 补肾活血汤干预骨-血耦连改善大鼠激素性股骨头坏死的作用机制研究. 中医药信息. 2023(06): 8-14 .
![]() | |
7. |
高晶,陈勇,王鹏飞,谢晓娟,王娜. 危重型新型冠状病毒合并细菌/真菌感染风险预测模型的建立及验证. 传染病信息. 2023(03): 208-212 .
![]() | |
8. |
李永哲. 自身免疫病实验诊断临床应用的机遇和挑战. 中华检验医学杂志. 2023(11): 1109-1112 .
![]() | |
9. |
李智平,陆权,刘瀚旻,宋红梅,张晓波,陈志敏,王诚,艾涛,班涛,陈星,陈艳妮,陈德晖,蔡栩栩,崔京浩,董晓艳,窦志国,付红敏,虎亚光,何军,韩志英,华山,金彦,鲁茜,刘建华,罗新辉,陆小霞,罗征秀,李嘉丽,马金海,覃敏,史天陆,田曼,王莹,王怀立,吴斌,向伟,闫美兴,余露山,赵顺英,周颖,赵昕,朱增燕,张雪梅,张海邻,朱晓萍,邹映雪,张磊,张馨欣. 儿童新型冠状病毒感染安全合理用药专家共识. 中国药学杂志. 2023(23): 2193-2200 .
![]() | |
10. |
王新宇,王彤,李雅静,严长宏. 基于网络药理学和分子对接探索严长宏教授核心处方治疗新型冠状病毒感染的作用机制. 中医临床研究. 2023(32): 7-14 .
![]() |