Volume 14 Issue 2
Mar.  2023
Turn off MathJax
Article Contents
LIN Yi, WANG Zhiliang, ZHAO Haiyan, ZHANG Lijuan, CHANG Hong. Changes and Clinical Significance of Serum Degraded Monosaccharides in Children with Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 292-298. doi: 10.12290/xhyxzz.2022-0681
Citation: LIN Yi, WANG Zhiliang, ZHAO Haiyan, ZHANG Lijuan, CHANG Hong. Changes and Clinical Significance of Serum Degraded Monosaccharides in Children with Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 292-298. doi: 10.12290/xhyxzz.2022-0681

Changes and Clinical Significance of Serum Degraded Monosaccharides in Children with Systemic Lupus Erythematosus

doi: 10.12290/xhyxzz.2022-0681

National Natural Science Foundation of China 81672585

More Information
  • Corresponding author: CHANG Hong, E-mail: 18661802671@yeah.net
  • Received Date: 2022-11-29
  • Accepted Date: 2023-02-01
  • Publish Date: 2023-03-30
  •   Objective  To investigate the characteristics of changes in serum degraded monosaccharide levels in children with systemic lupus erythematosus (SLE) and its relationship with the severity of the disease and immune dysfunction.  Methods  Children firstly diagnosed as SLE and hospitalized in the Affiliated Hospital of Qingdao University from January 2019 to March 2022 were enrolled in the SLE group, healthy childrenwho underwent physical examination at the same period were chosen as the control and matched in a ration of 1∶1 in age and sex with the SLE group. The clinical data of both groups were collected. The serum levels of five kinds of degraded monosaccharides, which were mannose, glucosamine, aminogalactose, N-acetyl glucosamine and galactose, were analyzed in both groups. The correlations between serum levels of degraded monosaccharides and SLE disease activity and immunologic markers were analyzed with Pearson correlation coefficient.  Results  Totally 45 children with SLE (13 with mild disease activity, 15 with moderate disease activity, and 17 with severe disease activity) and 50 healthy children were enrolled in the experiment. Compared with the control group, the SLE group showed elevated levels of serum mannose, glucosamine, aminogalactose, N-acetyl glucosamine, and galactose (all P < 0.05); and serum levels of mannose, N-acetyl glucosamine, and galactose gradually increased with increasing disease activity (all P < 0.05). There was no significant difference in glucosamine and aminogalactose levels in children with SLE of different disease activity (all P > 0.05). Pearson correlation coefficient showed that serum degraded monosaccharide levels were positively correlated with disease activity indexes and various immunologic markers.  Conclusions  Serum levels of degraded monosaccharides in children with SLE are elevated and some of which are correlated with disease activity and immune dysfunction.
  • loading
  • [1] 李文根, 古奕文, 张科, 等. 儿童与成人系统性红斑狼疮临床特点分析[J]. 中华实用儿科临床杂志, 2015, 30: 672-675. doi:  10.3760/cma.j.issn.2095-428X.2015.09.009
    [2] Flores-Mendoza G, Sanson SP, Rodriguez-Castro S, et al. Mechanisms of Tissue Injury in Lupus Nephritis[J]. Trends Mol Med, 2018, 24: 364-378. doi:  10.1016/j.molmed.2018.02.003
    [3] Morel L. Immunometabolism in systemic lupus erythematosus[J]. Nat Rev Rheumatol, 2017, 13: 280-290. doi:  10.1038/nrrheum.2017.43
    [4] Stathopoulou C, Nikoleri D, Bertsias G. Immunometabo-lism: an overview and therapeutic prospects in autoimmune diseases[J]. Immunotherapy, 2019, 11: 813-829. doi:  10.2217/imt-2019-0002
    [5] Alves I, Vicente MM, Dias AM, et al. The Role of Glycosylation in Inflammatory Diseases[J]. Adv Exp Med Biol, 2021, 1325: 265-283.
    [6] Panda AK, Parida JR, Tripathy R, et al. Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity[J]. Arthritis Res Ther, 2012, 14: R218. doi:  10.1186/ar4057
    [7] 王健, 李晞. 蛋白质糖基化修饰在自身免疫反应中的研究进展[J]. 检验医学与临床, 2021, 18: 128-131. doi:  10.3969/j.issn.1672-9455.2021.01.040
    [8] Vuckovic F, Kristic J, Gudelj I, et al. Association of systemic lupus erythematosus with decreased immunosuppres-sive potential of the IgG glycome[J]. Arthritis Rheumatol, 2015, 67: 2978-2989. doi:  10.1002/art.39273
    [9] Han J, Zhou Z, Zhang R, et al. Fucosylation of anti-dsDNA IgG1 correlates with disease activity of treatment-naive systemic lupus erythematosus patients[J]. EBioMedicine, 2022, 77: 103883. doi:  10.1016/j.ebiom.2022.103883
    [10] 王晓龙, 王秀然, 卢天成. 蛋白质糖基化修饰的研究进展[J]. 基因组学与应用生物学, 2017, 36: 4380-4384. doi:  10.13417/j.gab.036.004380
    [11] Mardinoglu A, Stancakova A, Lotta LA, et al. Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease[J]. Cell Metab, 2017, 26: 281-283. doi:  10.1016/j.cmet.2017.07.006
    [12] 王志亮, 盛楷迪, 林毅, 等. 过敏性紫癜患儿血清降解单糖水平的变化及意义[J]. 中国当代儿科杂志, 2022, 24: 894-898. doi:  10.7499/j.issn.1008-8830.2202125
    [13] Petri M, Orbai AM, Alarcon GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus[J]. Arthritis Rheum, 2012, 64: 2677-2686. doi:  10.1002/art.34473
    [14] 田新平, 李梦涛, 曾小峰. 从我国系统性红斑狼疮的诊治现状寻找可能的解决方案: 来自《中国系统性红斑狼疮发展报告2020》的启示[J]. 协和医学杂志, 2022, 13: 169-173. doi:  10.12290/xhyxzz.2022-0020
    [15] 中华医学会儿科学分会免疫学组, 中华儿科杂志编辑委员会. 中国儿童系统性红斑狼疮诊断与治疗指南[J]. 中华儿科杂志, 2021, 59: 1009-1024. doi:  10.3760/cma.j.cn112140-20210905-00743
    [16] Li M, Wang Q, Zhao J, et al. Chinese SLE Treatment and Research group (CSTAR) registry: Ⅱ. Prevalence and risk factors of pulmonary arterial hypertension in Chinese patients with systemic lupus erythematosus[J]. Lupus, 2014, 23: 1085-1091. doi:  10.1177/0961203314527366
    [17] Varki A. Biological roles of glycans[J]. Glycobiology, 2017, 27: 3-49. doi:  10.1093/glycob/cww086
    [18] 章晓联. 蛋白糖基化与免疫[J]. 中国免疫学杂志, 2004, 20: 290-293. doi:  10.3321/j.issn:1000-484X.2004.04.019
    [19] Zhou JY, Oswald DM, Oliva KD, et al. The Glycoscience of Immunity[J]. Trends Immunol, 2018, 39: 523-535. doi:  10.1016/j.it.2018.04.004
    [20] Kaneko Y, Nimmerjahn F, Ravetch JV. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation[J]. Science, 2006, 313: 670-673. doi:  10.1126/science.1129594
    [21] Fiebiger BM, Maamary J, Pincetic A, et al. Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type Ⅱ FcRs[J]. Proc Natl Acad Sci U S A, 2015, 112: E2385-E2394.
    [22] Cheng HD, Stockmann H, Adamczyk B, et al. High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis[J]. Glycobiology, 2017, 27: 1099-1108. doi:  10.1093/glycob/cwx082
    [23] Sjowall C, Zapf J, von Lohneysen S, et al. Altered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosus[J]. Lupus, 2015, 24: 569-581. doi:  10.1177/0961203314558861
    [24] Szabo E, Hornung A, Monostori E, et al. Altered Cell Surface N-Glycosylation of Resting and Activated T Cells in Systemic Lupus Erythematosus[J]. Int J Mol Sci, 2019, 20: 4455. doi:  10.3390/ijms20184455
    [25] Zhang M, Zhang Y, Ma X, et al. Using a PCR instrument to hydrolyze polysaccharides for monosaccharide composition analyses[J]. Carbohydr Polym, 2020, 240: 116338. doi:  10.1016/j.carbpol.2020.116338
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(2)

    Article Metrics

    Article views (2953) PDF downloads(14) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint