Tumor-associated Autoantibodies: Status and Prospect of Clinical Application

ZHAN Haoting; LI Yongzhe

doi:10.12290/xhyxzz.2021-0286

Volume 12 Issue 4

Jul. 2021

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Medical Journal of Peking Union Medical College Hospital > 2021 > 12(4): 438-444. > DOI: 10.12290/xhyxzz.2021-0286

ZHAN Haoting, LI Yongzhe. Tumor-associated Autoantibodies: Status and Prospect of Clinical Application[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 438-444. DOI: 10.12290/xhyxzz.2021-0286

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Tumor-associated Autoantibodies: Status and Prospect of Clinical Application

ZHAN Haoting¹,
LI Yongzhe^2, ,

1.
Graduate School, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
2.
Department of Clinical Laboratory, Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Natural Science Foundation of China 81871302

Beijing Key Clinical Specialty for Laboratory Medicine-Excellent Project ZK201000

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Corresponding author:
LI Yongzhe Tel: 86-10-69159713, E-mail: yongzhelipumch@126.com
Received Date: March 26, 2021
Accepted Date: June 02, 2021
Available Online: June 06, 2021
Issue Publish Date: July 29, 2021

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Abstract

Abstract

Tumor-associated autoantibodies are produced by abnormal exposure or presentation of tumor-associated antigen that promote autoimmune responses, elevation of which could be months or years in advance and participate in the occurrence and development of malignant transformation of tumors. In recent years, clinical application of tumor-associated autoantibodies has become increasingly prominent and provided a reference for early warning, risk assessment, diagnosis, prognosis and therapeutic efficacy in patients with cancer. This review mainly focused on the production mechanism, the status quo and future prospective of clinical application as well as research progress of tumor-associated autoantibodies in connective tissue diseases combined with tumors and malignancy.
- tumor-associated autoantibodies,
- connective tissue diseases,
- malignancy,
- biomarker,
- diagnosis

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References

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