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Zhi-lan MENG, Liang GAO, Jian-gang GU, Yu-feng LUO, Tao-ling ZHONG, Chen-yan ZHU. Application of Automatic DNA Image Cytometry in Diagnosis of Pleural Effusion[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 36-40. DOI: 10.3969/j.issn.1674-9081.2012.01.009
Citation: Zhi-lan MENG, Liang GAO, Jian-gang GU, Yu-feng LUO, Tao-ling ZHONG, Chen-yan ZHU. Application of Automatic DNA Image Cytometry in Diagnosis of Pleural Effusion[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 36-40. DOI: 10.3969/j.issn.1674-9081.2012.01.009
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Application of Automatic DNA Image Cytometry in Diagnosis of Pleural Effusion

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    • Abstract
  •   Objective  To study the application of DNA image cytometry (DNA-ICM) in the diagnosis of pleural effusion.
      Methods  DNA-ICM was applied for the determination of DNA levels in the cast-off cells from pleural effusion in 50 patients. Meanwhile, using the cytological test results as the standard, we analyzed the optimal thresholds of this technology in diagnosing the positive cases.
      Results  Compared with exfoliative cytology examination, DNA-ICM had a sensitivity of 87.5% and a specificity of 100% in the diagnosis, with a threshold of 1 cell when the DNA index ≥ 2.5.
      Conclusion  DNA-ICM can be promising in the diagnosis of pleural effusion, whereas its thresholds require further investigations.
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