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Volume 1 Issue 2
Oct.  2010
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Jie LIU, Yi XIAO. Wegener's Granulomatosis Combined with Pulmonary Tuberculosis: Report of 8 Cases and Literature Review[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(2): 167-170.
Citation: Jie LIU, Yi XIAO. Wegener's Granulomatosis Combined with Pulmonary Tuberculosis: Report of 8 Cases and Literature Review[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(2): 167-170.
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Wegener's Granulomatosis Combined with Pulmonary Tuberculosis: Report of 8 Cases and Literature Review

  • Department of Respiratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    XIAO Yi Tel:010-65295037, E-mail:xiaoyipumch@yahoo.com.cn

  • Received Date: July 31, 2010
  • Issue Publish Date: October 29, 2010
    Graphical Abstract
    • Abstract
  •   Objective  To analyze the clinical manifestations of patients with Wegener's granulomatosis (WG) and pulmonary tuberculosis (TB).
      Methods  We retrospectively analyzed the clinical data of 8 patients with Wegener's granulomatosis combined with pulmonary tuberculosis in Peking Union Medical College Hospital from May 1990 to May 2010.
      Results  There were 5 men and 3 women aged 19-70 years. Five patients were initially diagnosed as Wegener's granulomatosis but were confirmed to be with pulmonary tuberculosis during corticosteroid therapy. All these five patients had positive acid-fast bacilli smear test results, and four of them denied past a history of tuberculosis or tuberculosis exposure. Two were diagnosed as Wegener's granulomatosis and pulmonary tuberculosis almost the same time. In the remaining one case, tuberculosis was diagnosed firstly, and then Wegener's granulomatosis was also identified. The most common clinical manifestation in lung was hemoptysis, followed by cough and expectoration. Other involved organs included kidney (abnormal red blood cells in urine) and ear/nose/throat (suppuration and hearing impairment). Management was mainly based on anti-TB therapy and enhanced corticosteroid therapy.
      Conclusions  Patients with Wegener's granulomatosis combined with pulmonary tuberculosis are not uncommon. Early diagnosis and treatment can improve the prognosis.
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    • References (8)
  • [1]
    Cordier JF, Valeyre D, Guillevin L.Pulmonary Wegener's granulomatosis:a clinical and imaging study of 77 cases[J]. Chest, 1990, 97:906-912. DOI: 10.1378/chest.97.4.906
    [2]
    Duna GF, Galperin C, Hoffman GS.Wegener's granulomatosis[J]. Rheum Dis Clin North Am, 1995, 21:949-986. https://pubmed.ncbi.nlm.nih.gov/14968341/
    [3]
    Hagen EC, Daha MR, Hermans J, et al.Diagnostic value of standandized assays for anti-neutrophil cytoplasmic antibodies in idiopathicsy stemic vasculitis.EC/BCR Project for ANCA Assay Standardization[J]. Kidney Int, 1998, 53:743-753. DOI: 10.1046/j.1523-1755.1998.00807.x
    [4]
    Pradhan VD, Badakere SS, Ghosh K, et al.Spectrum of anti-neutrophil cytoplasmic antibodies in patients with pulmonary tuberculosis overlaps with that of Wegener's granulomatosis [J]. Indian J MedSci, 2004, 58:283-288. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=81391c72a549c8b1d5961370edf4b209
    [5]
    Flores-Suárez LF, Cabiedes J, Villa AR, et al.Prevalence of antineutrophil cytoplasmic autoantibodies in patients with tuberculosis[J]. Rheumatology, 2003, 42:223-229. DOI: 10.1093/rheumatology/keg066
    [6]
    Esquivel-Valerio JA, Flores-Suárez LF, Rodríguez-Amado J, et al, Antineutrophil cytoplasm autoantibodies inpatients with tuberculosis are directed against bactericidal/permeability increasing protein and are detected after treatment initiation [J]. Clin Exp Rheumatol, 2010, 28(1 Suppl57):35-39. http://www.ncbi.nlm.nih.gov/pubmed/20412700/
    [7]
    Stone JH, Merkel PA, Spiera R, et al.Rituximab versus cyclophosphamide for ANCA-associated vasculitis[J]. N Engl J Med, 2010, 363:221-232. DOI: 10.1056/NEJMoa0909905
    [8]
    Toyoshima M, Chida K, Suda T, et al.Wegener's granulomatosis responding to antituberculous drugs[J]. Chest, 2001, 119:643-645. DOI: 10.1378/chest.119.2.643
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