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Volume 13 Issue 2
Mar.  2022
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DAI Liyuan, SHI Yuankai, HAN Xiaohong. Advances in Dynamic Monitoring of Immune Checkpoint Inhibitors as the Prognostic Markers for Advanced Non-small Cell Lung Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 287-295. DOI: 10.12290/xhyxzz.2021-0608
Citation: DAI Liyuan, SHI Yuankai, HAN Xiaohong. Advances in Dynamic Monitoring of Immune Checkpoint Inhibitors as the Prognostic Markers for Advanced Non-small Cell Lung Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 287-295. DOI: 10.12290/xhyxzz.2021-0608
shu

Advances in Dynamic Monitoring of Immune Checkpoint Inhibitors as the Prognostic Markers for Advanced Non-small Cell Lung Cancer

  • 1.

    Department of Clinical Laboratory, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Cancer Center, National Clinical Research Center for Cancer, Beijing 100021, China

  • 2.

    Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Cancer Center, National Clinical Research Center for Cancer, Beijing 100021, China

  • 3.

    Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Cancer Center, National Clinical Research Center for Cancer, Beijing 100021, China

  • 4.

    Clinical Pharmacology Research Center, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 5.

    State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

Chinese National Major Project for New Drug Innovation 2019ZX09201-002

Chinese National Major Project for New Drug Innovation 2017ZX09304015

2022 Capital Health Development Scientific Research Project 2022-2z-4016

More Information
  • Corresponding author:

    HAN Xiaohong, E-mail: hanxiaohong@pumch.cn

  • Received Date: August 21, 2021
  • Accepted Date: October 12, 2021
  • Available Online: March 13, 2022
  • Issue Publish Date: March 29, 2022
    Graphical Abstract
    • Abstract
  • The use of immune checkpoint inhibitors(ICIs) in advanced non-small cell lung cancer(NSCLC) significantly improves survival, but it has clinical problems such as low response rate. Treatment of tumor with ICIs is a dynamic change that involves the process of tumor-immune system interaction. Vertical monitoring of dynamic changes of biomarkers is helpful to eliminate individual differences and to provide information on spatiotemporal heterogeneity of tumors. This paper reviews the biomarkers of advanced NSCLC, covering the aspects of treatment with ICIs from tumor cell origin, immune microenvironmental source and joint indicators.
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