Association between Hyperuricemia and Other Metabolism Dysfunctions

  Objective  To explore the association between hyperuricemia and other metabolism dysfunctions.

  Methods  A cross-sectional study in 2074 health examination subjects in our hospital in 2008. We calculated the prevalences of hyperuricemia and other metabolism dysfunctions and explored the association between hyperuricemia and other metabolism dysfunctions using bivariate correlation analysis and Logistic multiple analysis.

  Results  The prevalence were as follows:hyperuricemia is 14.27%, obesity 12.07%, hypertension 24.70%, fasting hyperglycaemia 19.46%, hypercholesteremia 36.38%, hypertriglyceridemia 28.68%, fatty liver 40.28%. The prevalences of metabolism dysfunctions were significantly higher in hyperuricemia group than in non-hyperuricemia group, and such significant differences still existed after having been adjusted with age. Bivariate correlation analysis showed that hyperuricemia was significantly correlated with age, gender, body mass index, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglyceride, non-high-density lipoprotein cholesterol, glucose, creatinine, and fatty liver. Logistic multiple regression analysis showed that the level of serum uric acid was independently associated with obesity, hypertension, low-density lipoprotein cholesterol, hypertriglyceridemia, and fatty liver.

  Conclusions  Hyperuricemia is independently associated with obesity, hypertension, hypertriglyceridemia, and fatty liver. It can increase the risk of these metabolic disorders.