Autoantibodies Involved in Neuropsychiatric Systemic Lupus Erythematosus and Its Diagnostic Value
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Abstract
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a group of severe complications with a poor prognosis and high mortality caused by systemic lupus erythematosus (SLE). Its lesions involve the nervous system and cause neurological and/or psychiatric symptoms. Unique autoantibodies detected in the serum or cerebrospinal fluid of patients with NPSLE are associated with the presence of neuropsychiatric disorders. The prevalence of NPSLE ranges from 17% to 75% in SLE. This article reviewed the latest progress and focused on the current state of knowledge and the potential clinical value of anti-ribosomal P antibody, antiphospholipid antibody, anti-neuronal antibody, and other related antibodies in NPSLE with central nervous involvement.
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