Zhen WANG, Zhong-wei CHENG, Tai-bo CHEN, Peng GAO, Quan FANG. Relationship between Non-sustained Ventricular Tachycardia before Implantation and Appropriate Therapy in Patients with Implantable Cardioverter Defibrillator for Primary Prevention of Sudden Cardiac Death[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(5): 494-498. DOI: 10.3969/j.issn.1674-9081.2019.05.012
Citation: Zhen WANG, Zhong-wei CHENG, Tai-bo CHEN, Peng GAO, Quan FANG. Relationship between Non-sustained Ventricular Tachycardia before Implantation and Appropriate Therapy in Patients with Implantable Cardioverter Defibrillator for Primary Prevention of Sudden Cardiac Death[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(5): 494-498. DOI: 10.3969/j.issn.1674-9081.2019.05.012

Relationship between Non-sustained Ventricular Tachycardia before Implantation and Appropriate Therapy in Patients with Implantable Cardioverter Defibrillator for Primary Prevention of Sudden Cardiac Death

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  • Corresponding author:

    FANG Quan Tel: 86-10-69155069, E-mail:13801371164@163.com

  • Received Date: March 03, 2019
  • Issue Publish Date: September 29, 2019
  •   Objective  The aim of this study was to explore the relationship between non-sustained ventricular tachycardia (NSVT) recorded by Holter before implantation and appropriate therapy in patients with implantable cardioverter defibrillator (ICD) for primary prevention of sudden cardiac death.
      Methods  A single-center retrospective cohort study was conducted. Consecutive inpatients who received ICD for primary prevention and finished Holter examination from January 2006 to December 2017 in Peking Union Medical College Hospital were enrolled. According to the results of Holter, the patients were divided into the NSVT group and the non-NSVT group. Clinic or telephone follow-ups were conducted until August 2018; the follow-up events included all-cause death, shock therapy, and anti-tachycardia pacing (ATP).
      Results  Sixty patients meeting the inclusive and exclusive criteria were enrolled in this study. Median follow-up of all patients was 37 (14-61) months. Kaplan-Meier curve and Log-Rank test showed that there was no significant difference in mortality between the NSVT and the non-NSVT group (P=0.108), while the NSVT group had a significantly higher rate of appropriate therapy (P=0.033). Multivariate competitive risk regression analysis indicated that NSVT and left ventricular ejection fraction were independently correlated with the ICD appropriate therapy (NSVT: HR=5.099, 95% CI:1.399-18.588, P=0.014; left ventricular ejection fraction: HR=1.077, 95% CI:1.013-1.145, P=0.018).
      Conclusion  NSVT in patients with ICD implantation for primary prevention suggests an increased risk of receiving appropriate therapy.
  • [1]
    Kostis JB, McCrone K, Moreyra AE, et al. Premature ventricular complexes in the absence of identifiable heart disease[J]. Circulation, 1981, 63:1351-1356. DOI: 10.1161/01.CIR.63.6.1351
    [2]
    Camm AJ, Evans KE, Ward DE, et al. The rhythm of the heart in active elderly subjects[J]. Am Heart J, 1980, 99:598-603. DOI: 10.1016/0002-8703(80)90733-4
    [3]
    Meinertz T, Hofmann T, Kasper W, et al. Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy[J]. Am J Cardiol, 1984, 53:902-907. DOI: 10.1016/0002-9149(84)90522-8
    [4]
    Massing MW, Simpson RJ, Rautaharju PM, et al. Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk In Communities cohort)[J]. Am J Cardiol, 2006, 98:1609-1612. DOI: 10.1016/j.amjcard.2006.06.061
    [5]
    Agarwal SK, Heiss G, Rautaharju PM, et al. Premature ventricular complexes and the risk of incident stroke:the Atherosclerosis Risk In Communities (ARIC) Study[J]. Stroke, 2010, 41:588-593. DOI: 10.1161/STROKEAHA.109.567800
    [6]
    Cheriyath P, He F, Peters I, et al. Relation of atrial and/or ventricular premature complexes on a two-minute rhythm strip to the risk of sudden cardiac death (the Atherosclerosis Risk in Communities[ARIC] study)[J]. Am J Cardiol, 2011, 107:151-155. DOI: 10.1016/j.amjcard.2010.09.002
    [7]
    Lee V, Hemingway H, Harb R, et al. The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease:a meta-analysis and systematic review[J]. Heart, 2012, 98:1290-1298. DOI: 10.1136/heartjnl-2012-302005
    [8]
    Bergau L, Willems R, Sprenkeler DJ, et al. Differential multivariable risk prediction of appropriate shock versus competing mortality-A prospective cohort study to estimate benefits from ICD therapy[J]. Int J Cardiol, 2018, 272:102-107. DOI: 10.1016/j.ijcard.2018.06.103
    [9]
    Killu AM, Mazo A, Grupper A, et al. Super-response to cardiac resynchronization therapy reduces appropriate implantable cardioverter defibrillator therapy[J]. Europace, 2018, 20:1303-1311. DOI: 10.1093/europace/eux235
    [10]
    Teerlink JR, Jalaluddin M, Anderson S, et al. Ambulatory ventricular arrhythmias in patients with heart failure do not specifically predict an increased risk of sudden death. PROMISE (Prospective Randomized Milrinone Survival Evaluation) Investigators[J]. Circulation, 2000, 101:40-46. DOI: 10.1161/01.CIR.101.1.40
    [11]
    Yokoshiki H, Shimizu A, Mitsuhashi T, et al. Prognostic significance of nonsustained ventricular tachycardia in patients receiving cardiac resynchronization therapy for primary preven-tion:Analysis of the Japan cardiac device treatment registry database[J]. J Arrhythm, 2018, 34:139-147. DOI: 10.1002/joa3.12023
    [12]
    Chen J, Johnson G, Hellkamp AS, et al. Rapid-rate nonsustained ventricular tachycardia found on implantable cardioverter-defibrillator interrogation:relationship to outcomes in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial)[J]. J Am Coll Cardiol, 2013, 61:2161-2168. DOI: 10.1016/j.jacc.2013.02.046
    [13]
    Jiménez-Candil J, Hernández J, Perdiguero P, et al. Prognostic significance of nonsustained ventricular tachycardia episodes occurring early after implantable cardioverter-defibrillator implantation among patients with left ventricular dysfunction[J]. Am J Cardiol, 2016, 118:1503-1510. DOI: 10.1016/j.amjcard.2016.08.015
    [14]
    Lee DS, Hardy J, Yee R, et al. Clinical risk stratification for primary prevention implantable cardioverter defibrillators[J]. Circ Heart Fail, 2015, 8:927-937. DOI: 10.1161/CIRCHEARTFAILURE.115.002414
    [15]
    Zhou Y, Zhao S, Chen K, et al. Predictive value of rapid-rate non-sustained ventricular tachycardia in the occurrence of appropriate implantable cardioverter-defibrillator therapy[J]. J Interv Card Electrophysiol, 2019.doi: 10.1007/s10840-019-00557-4.[Epub ahead of print].
    [16]
    Koller MT, Schaer B, Wolbers M, et al. Death without prior appropriate implantable cardioverter-defibrillator therapy:a competing risk study[J]. Circulation, 2008, 117:1918-1926. DOI: 10.1161/CIRCULATIONAHA.107.742155
    [17]
    Sticherling C, Arendacka B, Svendsen JH, et al. Sex differences in outcomes of primary prevention implantable cardioverter-defibrillator therapy:combined registry data from eleven European countries[J]. Europace, 2018, 20:963-970. DOI: 10.1093/europace/eux176
    [18]
    Seegers J, Conen D, Jung K, et al. Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators[J]. Europace, 2016, 18:1194-1202. DOI: 10.1093/europace/euv361
    [19]
    van der Heijden AC, Thijssen J, Borleffs CJ, et al. Gender-specific differences in clinical outcome of primary prevention implantable cardioverter defibrillator recipients[J]. Heart, 2013, 99:1244-1249. DOI: 10.1136/heartjnl-2013-304013
    [20]
    van Rees JB, Borleffs CJ, van Welsenes GH, et al. Clinical prediction model for death prior to appropriate therapy in primary prevention implantable cardioverter defibrillator patients with ischaemic heart disease:the FADES risk score[J]. Heart, 2012, 98:872-877. DOI: 10.1136/heartjnl-2011-300632
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