Email Alert RSS
Volume 9 Issue 3
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Man-man XU, Yun XU. Recurrent Ischemic Stroke[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(3): 285-288. DOI: 10.3969/j.issn.1674-9081.2018.03.018
Citation: Man-man XU, Yun XU. Recurrent Ischemic Stroke[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(3): 285-288. DOI: 10.3969/j.issn.1674-9081.2018.03.018
shu

Recurrent Ischemic Stroke

  • Department of Neurology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

More Information
  • Corresponding author:

    XU Yun Tel:025-68182212, E-mail: xuyun20042001@aliyun.com

  • Received Date: January 09, 2018
  • Issue Publish Date: May 29, 2018
    Graphical Abstract
    • Abstract
  • In some patients who have low or no response to antiplatelet drugs, cardiovascular and cerebrovascular events still happen with standard antiplatelet therapy. In this case report, a 63-year-old woman appeared repeated episodes of limb weakness, although she had taken antiplatelet drugs, i.e. aspirin and clopidogrel, for a long time. Every time, magnetic resonance imaging showed that she had a fresh cerebral infarction; and at the same time, platelet aggregation test, clotting test, and gene test indicated clopidogrel and aspirin resistance, which meant low or no response to antiplatelet therapy. We changed immediately to cilostazol and followed up for more than 1 year. This patient had no recurrence of cardiovascular and cerebrovascular events anymore.
    • FullText(HTML)
    • References (15)
  • [1]
    Esenwa C, Gutierrez J. Secondary stroke prevention:challenges and solutions[J]. Vasc Health Risk Manag, 2015, 11:437-450. http://pubmedcentralcanada.ca/pmcc/articles/PMC4536764/
    [2]
    Lee PN, Thornton AJ, Forey BA, et al. Environmental Tobacco Smoke Exposure and Risk of Stroke in Never Smokers:An Updated Review with Meta-Analysis[J]. J Stroke Cerebrovascular Dis, 2017, 26:204-216. DOI: 10.1016/j.jstrokecerebrovasdis.2016.09.011
    [3]
    SPSS3 Study Group, Benavente OR, Coffey CS, et al. Blood-pressure targets in patients with recent lacunar stroke:the SPS3 randomised trial[J]. Lancet, 2013, 382:507-515. DOI: 10.1016/S0140-6736(13)60852-1
    [4]
    Lin MP, Ovbiagele B, Markovic D, et al. Association of Secondhand Smoke with Stroke Outcomes[J]. Stroke, 2016, 47:2828-2835. DOI: 10.1161/STROKEAHA.116.014099
    [5]
    Fu J, Tang J, Yang J, et al. Adding computed tomography and transcranial Doppler findings to the ABCD2 score to predict long-term risk of stroke after transient ischaemic attack or minor stroke[J]. Eur J Neurol, 2015, 22:520-526. DOI: 10.1111/ene.12606
    [6]
    Chadha DS, Sumana B, Karthikeyan G, et al. Prevalence of aspirin resistance in Asian-Indian patients with stable coronary artery disease[J]. Catheter Cardiovasc Interv, 2016, 88:E126-E131. DOI: 10.1002/ccd.25420
    [7]
    Jia DM, Chen ZB, Zhang MJ, et al. CYP2C19 polymor-phisms and antiplatelet effects of clopidogrel in acute ischemic stroke in China[J]. Stroke, 2013, 44:1717-1719. DOI: 10.1161/STROKEAHA.113.000823
    [8]
    Cattaneo M, Cerletti C, Harrison P, et al. Recommendations for the Standardization of Light Transmission Aggregometry:A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH[J]. J Thromb Haemost, 2013, 11:1183-1189. DOI: 10.1111/jth.12231
    [9]
    Chen HY, Chou P. PFA-100-measured aspirin resistance is the predominant risk factor for hospitalized cardiovascular events in aspirin-treated patients:A 5-year cohort study[J]. J Clin Pharm Ther, 2018, 43:249-255. DOI: 10.1111/jcpt.12643
    [10]
    Quarterman C, Shaw M, Johnson I, et al. Intra- and inter-centre standardisation of thromboelastography (TEG®)[J]. Anaesthesia, 2014, 69:883-890. DOI: 10.1111/anae.12748
    [11]
    Fu Z, Dong W, Shen M, et al. Relationship between hyporesponsiveness to clopidogrel measured by thrombelastography and in stent restenosis in patients undergoing percutaneous coronary intervention[J]. Clin Biochem, 2014, 47:197-202. DOI: 10.1016/j.clinbiochem.2014.08.009
    [12]
    Lin YJ, Li JW, Zhang MJ, et al. The association between CYP2C19 genotype and of in-stent restenosis among patients with vertebral artery stent treatment[J]. CNS Neurosci Ther, 2014, 20:125-130. DOI: 10.1111/cns.12173
    [13]
    Pan Y, Chen W, Xu Y, et al. Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack:A Systematic Review and Meta-Analysis[J]. Circulation, 2017, 135:21-33. DOI: 10.1161/CIRCULATIONAHA.116.024913
    [14]
    Wang Y, Zhao X, Lin J, et al. Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack[J]. JAMA, 2016, 316:70-78. DOI: 10.1001/jama.2016.8662
    [15]
    Anderson CD, Biffi A, Greenberg SM, et al. Personalized approaches to clopidogrel therapy:are we there yet?[J].Stroke, 2010, 41:2997-3002. DOI: 10.1161/STROKEAHA.110.594069
    • Related Articles

  • Related Articles

    [1]LIU Miaomiao, YUE Hongmei, LI Yating, XU Jinhui, WU Xingdong, ZHU Haobin. Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 382-386. DOI: 10.12290/xhyxzz.2023-0452
    [2]WU Haiting, LI Hang. ANCA Associated Vasculitis Treated with Ultra-low Dose Rituximab: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1330-1334. DOI: 10.12290/xhyxzz.2023-0263
    [3]LIU Yuan, ZHAO Lin. Update and Interpretation of 2022 National Comprehensive Cancer Network Clinical Practice Guidelines for Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 999-1004. DOI: 10.12290/xhyxzz.2022-0271
    [4]WANG Guangjian, WANG Xiaoting. Host Response and Hemodynamics[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 929-935. DOI: 10.12290/xhyxzz.2022-0483
    [5]ZHANG Shu-yang. Strengthen Preparedness for Public Health Emergency and Response Capabilities of Public Academic Medical Centers[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(6): 641-644. DOI: 10.3969/j.issn.1674-9081.2020.06.002
    [6]Reziya ABUDUXUKUER, Shan LYU, Yao-de HE, Hang JIN, Zhen-ni GUO, Yi YANG. Rearch Course of Reperfusion Therapy for Acute Ischemic Stroke[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 162-169. DOI: 10.3969/j.issn.1674-9081.20190273
    [7]Lei LI, Feng-zhi FENG, Rong FAN, Wen-jia LOU, Yuan LI, Jia-li TONG, Xiao-yan CHANG, Ling-ya PAN. Fertility-sparing Surgery for Ovarian Non-invasive Low-grade Serous Carcinoma and Literature Review[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(4): 285-289. DOI: 10.3969/j.issn.1674-9081.2016.04.009
    [9]Ming-sheng MA, Xü-de ZHANG, Min WEI, Shi-min ZHAO, Zheng-qing QIU. Efficacy of Low Dose Corticosteroid Therapy in Duchenne Muscular Dystrophy[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(4): 384-388. DOI: 10.3969/j.issn.1674-9081.2014.04.006
    [10]Shuai TANG, Jie YI, Yu-guang HUANG. Cardiovascular Responses of Intubation with Shikani Seeing Optical Stylet and Macintosh Laryngoscope[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(3): 314-317. DOI: 10.3969/j.issn.1674-9081.2012.03.015

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views PDF downloads Cited by()
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close