Objective To investigate the characteristics of fertility-sparing surgery for non-invasive low-grade serous carcinoma (LGSC) of the ovary.
Methods All the histologically diagnosed patients of non-invasive LGSC who admitted to Peking Union Medical College Hospital and received fertility-sparing surgeries between January 2015 and June 2015 were reviewed and their clinicopathological characteristics, surgical procedures, and follow-up results were retrospectively analyzed.
Results Totally five cases of non-invasive LGSC receiving fertility-sparing surgeries were reviewed. Their median age was 29 years (range, 24-34 years). One case received laparotomy and four received laparoscopies; four cases received ovarian cystectomy and one received emergency unilateral adnexectomy for the affected and necrotic ovary because of acute torsion. One case was diagnosed at International Federation of Gynecology and Obstetrics (FIGO) stage IB, and the other four were at stage IA. All the five cases received no further therapy after the surgery. The median follow-up period was 7 months (range, 6-12 months). No case relapsed so far. One case conceived naturally and both the mother and the fetus were in good condition.
Conclusions For non-invasive LGSC patients, there are many unresolved issues in aspects of spare of fertility, conception after fertility-sparing surgeries, recurrence, and follow-up. Although the possibility to spare the ovary is supported by this study for young non-invasive LGSC patients, long-term prognosis (including fertility and survival) needs to be observed in further follow-up.