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ZHUO Qianli, ZHANG Zhaojun, FANG Xiangdong. Hematopoietic Engineering: The Current Status and Prospects of In Vitro Erythrocyte Production Technology[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0612
Citation: ZHUO Qianli, ZHANG Zhaojun, FANG Xiangdong. Hematopoietic Engineering: The Current Status and Prospects of In Vitro Erythrocyte Production Technology[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0612
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Hematopoietic Engineering: The Current Status and Prospects of In Vitro Erythrocyte Production Technology

  • 1 China National Center for Bioinformation, Beijing 100101, China;

  • 2 Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;

  • 3 University of Chinese Academy of Sciences, Beijing 100049, China;

  • 4 Beijing Key Laboratory of Genome and Precision Medicine Technologies, Beijing 100101, China

Funds: 

National Natural Science Foundation of China (82070114, 82270126)

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  • Received Date: August 07, 2024
  • Available Online: October 29, 2024
    Graphical Abstract
    • Abstract
  • The in vitro erythrocyte production technique provides a new solution for blood transfusion therapy, ensuring the sustainability of blood supply, reducing the dependency of blood donors, and lowering the risk of disease transmission. This review summarized the latest developments in erythrocyte production techniques in vitro, including the production of red blood cells from different cell sources. It emphasizes the cultivation techniques and the development of immortalized erythrocyte cell lines, highlighting the significance of enhancing enucleation rates and ensuring the safety of these lines. Furthermore, this review addresses the potential and challenges associated with clinical application, providing new insights for the sustainable supply and clinical practice of red blood cells in the future.
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