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Volume 14 Issue 3
May  2023
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KANG Junren, XU Qiang, LI Hailong, WEI Wei. Clinical Research Progress of the Intragastric Balloon for Weight Loss[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 591-597. DOI: 10.12290/xhyxzz.2022-0486
Citation: KANG Junren, XU Qiang, LI Hailong, WEI Wei. Clinical Research Progress of the Intragastric Balloon for Weight Loss[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 591-597. DOI: 10.12290/xhyxzz.2022-0486
shu

Clinical Research Progress of the Intragastric Balloon for Weight Loss

  • 1.

    Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National High Level Hospital Clinical Research Funding 2022-PUMCH-A-061

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  • Corresponding author:

    KANG Junren, E-mail: kangjunren@pumch.cn

  • Received Date: August 28, 2022
  • Accepted Date: November 15, 2022
  • Available Online: April 25, 2023
  • Issue Publish Date: May 29, 2023
    Graphical Abstract
    • Abstract
  • The intragastric balloon (IGB), a non-invasive temporary method for obesity, can induce weight loss by placing a soft saline-or air-filled balloon in the stomach to reduce gastric capacity and delay gastric emptying. IGB is an option for individuals with obesity who have failed at weight management with diet and exercise or are unwilling to undergo bariatric surgery. Besides, IGB can also be used as a bridging intervention prior to bariatric surgery. IGB has been proven to be effective in inducing weight loss, with a low incidence of serious complications by clinical practice from foreign countries. However, the long-term follow-up for its effects on weight loss and metabolic improvement of IGB need to be verified in the future. The IGB has not been approved for clinical application in China. In this review, we discuss the indications and contraindications of IGB as well as its effects on weight loss and its complications.
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    • References (46)
  • [1]
    Chen Y, Peng Q, Yang Y, et al. The prevalence and increasing trends of overweight, general obesity, and abdominal obesity among Chinese adults: a repeated cross-sectional study[J]. BMC Public Health, 2019, 19: 1293. DOI: 10.1186/s12889-019-7633-0
    [2]
    NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants[J]. Lancet, 2016, 387: 1377-1396. DOI: 10.1016/S0140-6736(16)30054-X
    [3]
    中国居民营养与慢性病状况报告(2020年)[J]. 营养学报, 2020, 42: 521.
    [4]
    Mingrone G, Panunzi S, De Gaetano A, et al. Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial[J]. Lancet, 2021, 397: 293-304. DOI: 10.1016/S0140-6736(20)32649-0
    [5]
    中华医学会肠外肠内营养学分会营养与代谢协作组, 北京协和医院减重多学科协作组. 减重手术的营养与多学科管理专家共识[J]. 中华外科杂志, 2018, 56: 81-90.
    [6]
    中华医学会外科学分会甲状腺及代谢外科学组, 中国医师协和外科医师分会肥胖和糖尿病外科医师委员会. 中国肥胖及2型糖尿病外科治疗指南(2019版)[J]. 中国实用外科杂志, 2019, 39: 301-306. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201904001.htm
    [7]
    Telem DA, Ghaferi AA. Gastric Balloons for Weight Loss in 2020[J]. JAMA, 2020, 324: 2206-2207. DOI: 10.1001/jama.2020.14862
    [8]
    Zerrweck C, Maunoury V, Caiazzo R, et al. Preoperative weight loss with intragastric balloon decreases the risk of significant adverse outcomes of laparoscopic gastric bypass in super-super obese patients[J]. Obes Surg, 2012, 22: 777-782. DOI: 10.1007/s11695-011-0571-2
    [9]
    Lari E, Burhamah W, Lari A, et al. Intra-gastric balloons-The past, present and future[J]. Ann Med Surg (Lond), 2021, 63: 102138. http://pubmed.ncbi.nlm.nih.gov/33664941/
    [10]
    Mechanick JI, Apovian C, Brethauer S, et al. Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures- 2019 Update: cosponsored by American Association Of Clinical Endocrinologists/American College Of Endocrinology, The Obesity Society, American Society For Metabolic & Bariatric Surgery, Obesity Medicine Association, And American Society Of Anesthesiologists-Executive Summary[J]. Endocr Pract, 2019, 25: 1346-1359. http://www.researchgate.net/publication/336998068_Clinical_Practice_Guidelines_for_the_Perioperative_Nutrition_Metabolic_and_Nonsurgical_Support_of_Patients_Undergoing_Bariatric_Procedures_-_2019_Update
    [11]
    Gleysteen JJ. A history of intragastric balloons[J]. Surg Obes Relat Dis, 2016, 12: 430-435. http://smartsearch.nstl.gov.cn/paper_detail.html?id=7e1c459163c9a43291cd349f2363636d
    [12]
    Reja D, Zhang C, Sarkar A. Endoscopic bariatrics: current therapies and future directions[J]. Transl Gastroenterol Hepatol, 2022, 7: 21. DOI: 10.21037/tgh.2020.03.09
    [13]
    Courcoulas A, Abu Dayyeh BK, Eaton L, et al. Intragastric balloon as an adjunct to lifestyle intervention: a randomized controlled trial[J]. Int J Obes (Lond), 2017, 41: 427-433. DOI: 10.1038/ijo.2016.229
    [14]
    Abu Dayyeh BK, Maselli DB, Rapaka B, et al. Adjustable intragastric balloon for treatment of obesity: a multicentre, open-label, randomised clinical trial[J]. Lancet, 2021, 398: 1965-1973. DOI: 10.1016/S0140-6736(21)02394-1
    [15]
    Neto MG, Silva LB, Grecco E, et al. Brazilian Intragastric Balloon Consensus Statement (BIBC): practical guidelines based on experience of over 40, 000 cases[J]. Surg Obes Relat Dis, 2018, 14: 151-159. DOI: 10.1016/j.soard.2017.09.528
    [16]
    Sachdev P, Reece L, Thomson M, et al. Intragastric balloon as an adjunct to lifestyle programme in severely obese adolescents: impact on biomedical outcomes and skeletal health[J]. Int J Obes (Lond), 2018, 42: 115-118. DOI: 10.1038/ijo.2017.215
    [17]
    Ashrafian H, Monnich M, Braby TS, et al. Intragastric balloon outcomes in super-obesity: a 16-year city center hospital series[J]. Surg Obes Relat Dis, 2018, 14: 1691-1699. DOI: 10.1016/j.soard.2018.07.010
    [18]
    Loo JH, Lim YH, Seah HL, et al. Intragastric Balloon as Bridging Therapy Prior to Bariatric Surgery for Patients with Severe Obesity (BMI ≥ 50 kg/m2): a Systematic Review and Meta-analysis[J]. Obes Surg, 2022, 32: 489-502. DOI: 10.1007/s11695-021-05772-5
    [19]
    Laing P, Pham T, Taylor LJ, et al. Filling the Void: A Review of Intragastric Balloons for Obesity[J]. Dig Dis Sci, 2017, 62: 1399-1408. DOI: 10.1007/s10620-017-4566-2
    [20]
    Pak HJ, Choi HN, Lee HC, et al. Effects of intragastric balloon on obesity in obese Korean women for 6 months post removal[J]. Nutr Res Pract, 2021, 15: 456-467. DOI: 10.4162/nrp.2021.15.4.456
    [21]
    Phillips RJ, Powley TL. Gastric volume rather than nutrient content inhibits food intake[J]. Am J Physiol, 1996, 271: R766-R769.
    [22]
    Gómez V, Woodman G, Abu Dayyeh BK. Delayed gastric emptying as a proposed mechanism of action during intragastric balloon therapy: Results of a prospective study[J]. Obesity (Silver Spring), 2016, 24: 1849-1853. DOI: 10.1002/oby.21555
    [23]
    Ly HG, Dupont P, Van Laere K, et al. Differential brain responses to gradual intragastric nutrient infusion and gastric balloon distension: A role for gut peptides?[J]. Neuroimage, 2017, 144: 101-112. DOI: 10.1016/j.neuroimage.2016.09.032
    [24]
    Suchartlikitwong S, Laoveeravat P, Mingbunjerdsuk T, et al. Usefulness of the ReShape intragastric balloon for obesity[J]. Proc (Bayl Univ Med Cent), 2019, 32: 192-195.
    [25]
    Vantanasiri K, Matar R, Beran A, et al. The Efficacy and Safety of a Procedureless Gastric Balloon for Weight Loss: a Systematic Review and Meta-Analysis[J]. Obes Surg, 2020, 30: 3341-3346. DOI: 10.1007/s11695-020-04522-3
    [26]
    Fittipaldi-Fernandez RJ, Zotarelli-Filho IJ, Diestel CF, et al. Randomized Prospective Clinical Study of Spatz3® Adjustable Intragastric Balloon Treatment with a Control Group: a Large-Scale Brazilian Experiment[J]. Obes Surg, 2021, 31: 787-796. DOI: 10.1007/s11695-020-05014-0
    [27]
    ASGE Bariatric Endoscopy Task Force and ASGE Technology Committee, Abu Dayyeh BK, Kumar N, et al. ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies[J]. Gastrointest Endosc, 2015, 82: 425-438. DOI: 10.1016/j.gie.2015.03.1964
    [28]
    Lopez-Nava G, Bautista-Castaño I, Jimenez-Baños A, et al. Dual Intragastric Balloon: Single Ambulatory Center Spanish Experience with 60 Patients in Endoscopic Weight Loss Management[J]. Obes Surg, 2015, 25: 2263-2267. DOI: 10.1007/s11695-015-1715-6
    [29]
    Ienca R, Al Jarallah M, Caballero A, et al. The Procedureless Elipse Gastric Balloon Program: Multicenter Experience in 1770 Consecutive Patients[J]. Obes Surg, 2020, 30: 3354-3362. DOI: 10.1007/s11695-020-04539-8
    [30]
    Jamal MH, Al-Kanawati N, ElAbd R, et al. A Study Examining the Orbera365 Intragastric Balloon Safety and Effects on Weight Loss[J]. Obes Surg, 2021, 31: 5342-5347. DOI: 10.1007/s11695-021-05729-8
    [31]
    Stavrou G, Shrewsbury A, Kotzampassi K. Six intragastric balloons: Which to choose?[J]. World J Gastrointest Endosc, 2021, 13: 238-259. http://qikan.cqvip.com/Qikan/Article/Detail?id=7105366372
    [32]
    Kumar N, Bazerbachi F, Rustagi T, et al. The Influence of the Orbera Intragastric Balloon Filling Volumes on Weight Loss, Tolerability, and Adverse Events: a Systematic Review and Meta-Analysis[J]. Obes Surg, 2017, 27: 2272-2278. DOI: 10.1007/s11695-017-2636-3
    [33]
    Ohta M, Maekawa S, Imazu H, et al. Endoscopic intragastric balloon therapy for 15 years in Japan: Results of nationwide surveys[J]. Asian J Endosc Surg, 2021, 14: 401-407. DOI: 10.1111/ases.12881
    [34]
    Kotzampassi K, Grosomanidis V, Papakostas P, et al. 500 intragastric balloons: what happens 5 years thereafter?[J]. Obes Surg, 2012, 22: 896-903. DOI: 10.1007/s11695-012-0607-2
    [35]
    Genco A, Bruni T, Doldi SB, et al. BioEnterics Intragastric Balloon: The Italian Experience with 2, 515 Patients[J]. Obes Surg, 2005, 15: 1161-1164. DOI: 10.1381/0960892055002202
    [36]
    Spyropoulos C, Katsakoulis E, Mead N, et al. Intragastric balloon for high-risk super-obese patients: a prospective analysis of efficacy[J]. Surg Obes Relat Dis, 2007, 3: 78-83. DOI: 10.1016/j.soard.2006.11.001
    [37]
    Ponce J, Woodman G, Swain J, et al. The REDUCE pivotal trial: a prospective, randomized controlled pivotal trial of a dual intragastric balloon for the treatment of obesity[J]. Surg Obes Relat Dis, 2015, 11: 874-881. DOI: 10.1016/j.soard.2014.12.006
    [38]
    Sullivan S, Swain J, Woodman G, et al. Randomized sham-controlled trial of the 6-month swallowable gas-filled intragastric balloon system for weight loss[J]. Surg Obes Relat Dis, 2018, 14: 1876-1889. DOI: 10.1016/j.soard.2018.09.486
    [39]
    Moore RL, Seger MV, Garber SM, et al. Clinical safety and effectiveness of a swallowable gas-filled intragastric balloon system for weight loss: consecutively treated patients in the initial year of U.S. commercialization[J]. Surg Obes Relat Dis, 2019, 15: 417-423. DOI: 10.1016/j.soard.2018.12.007
    [40]
    Brooks J, Srivastava ED, Mathus-Vliegen EM. One-year adjustable intragastric balloons: results in 73 consecutive patients in the U. K[J]. Obes Surg, 2014, 24: 813-819. DOI: 10.1007/s11695-014-1176-3
    [41]
    Daniel F, Abou Fadel C, Houmani Z, et al. Spatz 3 Adjustable Intragastric Balloon: Long-Term Safety Concerns[J]. Obes Surg, 2016, 26: 159-160. DOI: 10.1007/s11695-015-1897-y
    [42]
    Ramai D, Singh J, Mohan BP, et al. Influence of the Elipse Intragastric Balloon on Obesity and Metabolic Profile: A Systematic Review and Meta-Analysis[J]. J Clin Gastroenterol, 2021, 55: 836-841. DOI: 10.1097/MCG.0000000000001484
    [43]
    Willett WC, Dietz WH, Colditz GA. Guidelines for healthy weight[J]. N Engl J Med, 1999, 341: 427-434. DOI: 10.1056/NEJM199908053410607
    [44]
    Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss[J]. N Engl J Med, 2011, 365: 1597-1604. DOI: 10.1056/NEJMoa1105816
    [45]
    van Baak MA, Mariman ECM. Mechanisms of weight regain after weight loss-the role of adipose tissue [J]. Nat Rev Endocrinol, 2019, 15: 274-287. DOI: 10.1038/s41574-018-0148-4
    [46]
    Alfredo G, Roberta M, Massimiliano C, et al. Long-term multiple intragastric balloon treatment--a new strategy to treat morbid obese patients refusing surgery: prospective 6-year follow-up study[J]. Surg Obes Relat Dis, 2014, 10: 307-311. DOI: 10.1016/j.soard.2013.10.013
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