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Volume 13 Issue 5
Sep.  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(5): 732-739
HUANG Ziyu, ZUO Tao, LAN Ping. Gastrointestinal Diseases and Gut Microbiome Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 732-739. doi: 10.12290/xhyxzz.2022-0208
Citation: HUANG Ziyu, ZUO Tao, LAN Ping. Gastrointestinal Diseases and Gut Microbiome Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 732-739. doi: 10.12290/xhyxzz.2022-0208
shu

Gastrointestinal Diseases and Gut Microbiome Therapy

doi: 10.12290/xhyxzz.2022-0208
  • 1.

    Guangdong Institute of Gastroenterology, Guangzhou 510655, China

  • 2.

    Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

  • 3.

    Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China

Funds:

National Natural Science Foundation of China U21A20344

National Natural Science Foundation of China 82172323

National Natural Science Foundation of China 32100134

National Key Clinical Discipline; Municipal Key Research and Development Program of Guangzhou 202206010014

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    Abstract
  • Gut microbiome regulates host metabolism and immunity via their metabolites, secretions, and cellular components, and protects the host from pathogen invasion. Low diversity and dysfunction of the gut microbiome caused by environmental changes, unhealthy dietary habits and lifestyles, and antibiotics abuse are closely related to disease pathogenesis. Gut microbiome can serve as diagnostic and therapeutic tools for diseases related to gut microbiome dysbiosis. In this article, we aim to review the latest study advances on gut microbiome in the pathogenesis and therapeutics of gastrointestinal diseases, such as Clostridium difficile infection, Helicobacter pylori infection, inflammatory bowel disease, and irritable bowel syndrome, so as to shed light on the prospect of gut microbiome modulations in disease therapies.
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