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Volume 13 Issue 3
May  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(3): 473-479
TANG Jue, YAO Zhirong. Research and Therapy Progress on the Mechanisms of Pruritus in Atopic Dermatitis[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 473-479. doi: 10.12290/xhyxzz.2021-0747
Citation: TANG Jue, YAO Zhirong. Research and Therapy Progress on the Mechanisms of Pruritus in Atopic Dermatitis[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 473-479. doi: 10.12290/xhyxzz.2021-0747
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Research and Therapy Progress on the Mechanisms of Pruritus in Atopic Dermatitis

doi: 10.12290/xhyxzz.2021-0747

  • Department of Dermatology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Funds:

National Natural Science Foundation of China 81874252

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  • Corresponding author: YAO Zhirong, E-mail：yaozhirong@xinhuamed.com.cn
  • Received Date: 2021-11-14
  • Accepted Date: 2022-01-10
    • Available Online: 2022-05-13
  • Publish Date: 2022-05-30
    Abstract
  • Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease characterized by intense pruritus. A satisfactory understanding of itch in AD has been proved difficult to reach and the relapsing itch is believed to be primarily a result of dysfunction of the skin barrier, dysregulation of the immune system and multiple environmental factors. Itch-scratch cycle exacerbates skin lesions, promotes inflammation and neurological disorders, and triggers the desire to continue scratching. The current methods of treatment for controlling AD pruritus symptoms include topical and systemic drugs. The exploration on the mechanisms of atopic pruritus has provided novel therapeutic targets, such as IL-4, IL-13, IL-31, JAK, IL-33. The new advances in the mechanism and treatment of itch in AD were systemically reviewed.
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