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Volume 12 Issue 5
Sep.  2021
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WU Jun, FEI Sijia, SHEN Bo, ZHANG Hanwen, HUANG Jianfeng, PAN Qi, ZHAO Jianchun, DING Dayong. Artificial Intelligence Analysis of Nerve Fibers Based on Corneal Confocal Microscopy[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(5): 736-741. DOI: 10.12290/xhyxzz.2021-0510
Citation: WU Jun, FEI Sijia, SHEN Bo, ZHANG Hanwen, HUANG Jianfeng, PAN Qi, ZHAO Jianchun, DING Dayong. Artificial Intelligence Analysis of Nerve Fibers Based on Corneal Confocal Microscopy[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(5): 736-741. DOI: 10.12290/xhyxzz.2021-0510
shu

Artificial Intelligence Analysis of Nerve Fibers Based on Corneal Confocal Microscopy

  • 1.

    School of Electronics and Information, Northwestern Polytechnical University, Xi'an 710072, China

  • 2.

    Graduate School, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Ophthalmology, Beijing hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

  • 4.

    Department of Endocrinology, Beijing hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

  • 5.

    Vistel AI Lab, Visionary Intelligent Ltd., Beijing 100872, China

Funds: 

China National Key R & D Program 2020YFC2009006

China National Key R & D Program 2020YFC2009000

Natural Science Basic Research Plan in Shaanxi Province of China 2020JM-129

Seed Foundation of Innovation and Creation for Postgraduate Students in Northwestern Polytechnical University CX2020162

National Innovation and Entrepreneurship Training Program for College Students S202010699207

National Innovation and Entrepreneurship Training Program for College Students S202010699630

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  • Corresponding author:

    PAN Qi   Tel: 86-10-85138663, E-mail: panqi621@126.com

  • Received Date: July 01, 2021
  • Accepted Date: July 28, 2021
  • Available Online: September 21, 2021
  • Issue Publish Date: September 29, 2021
    Graphical Abstract
    • Abstract
  • Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Traditional DPN diagnostic methods are based on clinical symptoms and signs as well as electrophysiological examination, which are mainly used to detect the lesions of large nerve fibers. However, the small nerve fibers are the earliest ones damaged in DPN. Corneal confocal microscopy (CCM) can analyze the changes of corneal nerve fibers under a high power microscope. It is a rapid, repeatable and quantitative noninvasive technique to measure small nerve fibers. It can diagnose DPN early and evaluate neuromorphological changes prospectively. It has a good application expectation. During this article, we summarized the role and limitations of DPN's most reliable parameters of corneal nerve in evaluating diabetic autonomic neuropathy and diabetic micro-vascular complications. Further, we reviewed the clinical application of CCM in evaluating diabetic neuropathy and analysis methods of CCM related artificial intelligence, in order to provide references for clinical diagnosis and treatment.
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    • References (37)
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