DU Juan, ZHANG Dong, ZHANG Rui, CHEN Yu, YI Jie, WU Jie, DOU Yaling, YANG Zhuo, YE Ali, KONG Lingjun, GAN Yong, YANG Qiwen. Analysis of Four Common Pathogens of Sexually Transmitted Diseases in Peking Union Medical College Hospital from 2013 to 2018[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 518-525. DOI: 10.12290/xhyxzz.2021-0304
Citation: DU Juan, ZHANG Dong, ZHANG Rui, CHEN Yu, YI Jie, WU Jie, DOU Yaling, YANG Zhuo, YE Ali, KONG Lingjun, GAN Yong, YANG Qiwen. Analysis of Four Common Pathogens of Sexually Transmitted Diseases in Peking Union Medical College Hospital from 2013 to 2018[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 518-525. DOI: 10.12290/xhyxzz.2021-0304

Analysis of Four Common Pathogens of Sexually Transmitted Diseases in Peking Union Medical College Hospital from 2013 to 2018

Funds: 

Beijing Key Clinical Specialty for Laboratory Medicine-Excellent Project ZK201000

More Information
  • Corresponding author:

    YANG Qiwen  Tel: 86-10-69159742, E-mail: yangqiwen81@vip.163.com

  • Received Date: March 31, 2021
  • Accepted Date: June 09, 2021
  • Issue Publish Date: July 29, 2021
  •   Objective  To explore the prevalence of Chlamydia trachomatis(CT), Neisseria gonorrhoeae(NG), Ureaplasma urealyticum(UU), and Mycoplasma genitalium(MG) in patients with suspected sexually transmitted diseases(STD) in Peking Union Medical College Hospital(PUMCH), and to provide evidence for clinical treatment.
      Methods  The samples (including urine and genital swabs) of suspected STD patients in PUMCH between January 2013 and December 2018 were collected retrospectively. CT, UU, MG, and NG were detected using the simultaneous amplification and testing technique.
      Results  A total of 12 804 samples were analyzed. The positive rates of the four pathogens were 42.88% (4833/11 271)for UU, 8.43% (905/10 739) for CT, 5.44% (231/4246) for MG and 3.78% (338/8932) for NG. UU+CT(4.13%, 402/9725) and UU + MG (1.98%, 74/3745) were common co-infections. The positive rates of UU in female patients were higher than those in male patients of the same age, while the positive rates of CT, NG, and MG in female patients were lower than those in male patients. Except for NG and UU in female, the positive rate of single infection and co-infection(UU+CT, UU+MG) in patients ≤20 years old was the highest. The positive rates of NG and MG decreased, while the positive rates of CT and UU fluctuated in a small range. Among male patients, the positive rate of NG in urethral swabs was significantly higher than that in urine samples (12.37% vs. 5.27%, P < 0.001). Among female patients, the positive rate of UU in cervical swabs was significantly higher than that in urine (61.78% vs. 54.74%, P < 0.001) and the positive rate of CT in cervical swabs was significantly lower than that in urine (6.16% vs. 7.73%, P=0.022).
      Conclusions  From 2013 to 2018, the prevalence rates of four common STD pathogens from high to low were UU, CT, MG, and NG. UU+CT and UU+MG were common co-infections. The young people at the age of ≤20 had the highest positive rates. The positive detection rate of different items varies with different specimen types.
  • [1]
    Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guide-lines, 2015[J]. MMWR Recomm Rep, 2015, 64: 1-137. DOI: 10.15585/mmwr.rr6404a1
    [2]
    Horner P, Blee K, O'Mahony C, et al. 2015 UK National Guideline on the management of non-gonococcal urethritis[J]. Int J STD AIDS, 2016, 27: 85-96. DOI: 10.1177/0956462415586675
    [3]
    朱学骏, 顾有守, 沈丽玉. 实用皮肤性病治疗学[M]. 北京: 北京大学医学出版社, 2015: 503.
    [4]
    武卫华, 郝翠芳, 田丽娟, 等. 宫颈分泌物与盆腔液解脲支原体与沙眼衣原体检测在输卵管性不孕患者感染评估中的应用[J]. 中华医院感染学杂志, 2017, 27: 5216-5219. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201722048.htm

    Wu WH, Hao CF, Tian LJ, et al. Application of detection of Ureaplasma urealyticum and Chlamydia trachomatis in cervical secretion and pelvic fluid in the evaluation of infection in tubal infertility patients[J]. Zhonghua Yiyuan Ganranxue Zazhi, 2017, 27: 5216-5219. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201722048.htm
    [5]
    Dehon PM, Mcgowin CL. Mycoplasma genitalium infection is associated with microscopic signs of cervical inflam-mationin liquid cytology specimens[J]. J Clin Microbiol, 2014, 52: 2398-2405. DOI: 10.1128/JCM.00159-14
    [6]
    Capoccia R, Greub G, Band D. Ureaplasma urealytium, Mycoplasma hominis and adverse pregnancy outcomes[J]. Curr Opin Infect Dis, 2013, 26: 231-240. DOI: 10.1097/QCO.0b013e328360db58
    [7]
    Tully JG, Taylor-Robinson D, Cole RM, et al. A newly discovered mycoplasma in the human urogenital tract[J]. Lancet, 1981, 1: 1288-1291. http://sti.bmj.com/lookup/external-ref?access_num=6112607&link_type=MED&atom=
    [8]
    Manhart LE, Critchlow CW, Holmes KK, et al. Mucopuru-lent cervicitis and Mycoplasma genitalium[J]. J Infect Dis, 2003, 187: 650-657. DOI: 10.1086/367992
    [9]
    Cohen CR, Manhart LE, Bukusi EA, et al. Association between Mycoplasma genitalium and acute endometritis[J]. Lancet, 2002, 359: 765-766. DOI: 10.1016/S0140-6736(02)07848-0
    [10]
    Clausen HF, Fedder J, Drasbek M, et al. Serological investigation of Mycoplasma genitalium in infertile women[J]. Hum Reprod, 2001, 16: 1866-1874. DOI: 10.1093/humrep/16.9.1866
    [11]
    张静, 王海滨, 时宇. STD门诊患者沙眼衣原体、解脲支原体、淋球菌与人乳头瘤病毒感染情况分析[J]. 标记免疫分析与临床, 2015, 22: 725-728. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201508005.htm

    Zang J, Wang HB, Shi Y. Analysis of Chlamydia Trachomatis, Ureaplasma Urealyticum, Neisseria Gonorrhoeae and Human Papillomavirus Infections in STD Cases[J]. Biaoji Mianyi Fenxi Yu Linchuang, 2015, 22: 725-728. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201508005.htm
    [12]
    周小剑, 唐湘, 李玉华. 某院3种性传播疾病的流行病学分析[J]. 现代诊断与治疗, 2016, 27: 4085-4086. DOI: 10.3969/j.issn.1001-8174.2016.21.055
    [13]
    王敬仁, 陈杏园, 罗世强, 等. 生殖系统CT、UU、NG三种病原体感染现状分析[J]. 分子诊断与治疗杂志, 2018, 10: 91-95. DOI: 10.3969/j.issn.1674-6929.2018.02.005

    Wang JR, Chen XY, Luo SQ, et al. Analysis of the prevalence of CT, UU and NG in reproductive system[J]. Fenzi Zhenduan Yu Zhiliao Zazhi, 2018, 10: 91-95. DOI: 10.3969/j.issn.1674-6929.2018.02.005
    [14]
    Casin I, Vexiau-Robert D, De La Salmonière P, et al. High prevalence of Mycoplasma genitalium in the lower genitourinary tract of women attending a sexually transmitted disease clinic in Paris, France[J]. Sex Transm Dis, 2002, 29: 353-359. DOI: 10.1097/00007435-200206000-00008
    [15]
    Huppert JS, Mortensen JE, Reed JL, et al. Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women[J]. Sex Transm Dis, 2008, 35: 250-254. DOI: 10.1097/OLQ.0b013e31815abac6
    [16]
    Tosh AK, Van Der Pol B, Fortenberry JD, et al. Mycoplasma genitalium among adolescent women and their partners[J]. J Adolesc Health, 2007, 40: 412-417. DOI: 10.1016/j.jadohealth.2006.12.005
    [17]
    Vandepitte J, Muller E, Bukenya J, et al. Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda[J]. J Infect Dis, 2012, 205: 289-296. DOI: 10.1093/infdis/jir733
    [18]
    Gaydos C, Maldeis NE, Hardick A, et al. Mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiological agent of urethritis in men attending STD clinics[J]. Sex Transm Infect, 2009, 85: 438-440. DOI: 10.1136/sti.2008.035477
    [19]
    Mena L, Wang X, Mroczkowski TF, et al. Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans[J]. Clin Infect Dis, 2002, 35: 1167-1173. DOI: 10.1086/343829
    [20]
    Taylor-Robinson D, Renton A, Jensen JS, et al. Association of Mycoplasma genitalium with acute non-gonococcal ure-thritis in Russian men: a comparison with gonococcal and chlamydial urethritis[J]. Int J STD AIDS, 2009, 20: 234-237. DOI: 10.1258/ijsa.2008.008298
    [21]
    Mavedzenge SN, Van Der Pol B, Weiss HA, et al. The association between Mycoplasma genitalium and HIV-1 acquisition in African women[J]. AIDS, 2012, 26: 617-624. DOI: 10.1097/QAD.0b013e32834ff690
    [22]
    Centers for Disease Control and Prevention(CDC) Grand Rounds. Chlamydia prevention: challenges and strategies for reducing disease burden and sequelae[J]. Morb Mortal Wkly Rep, 2011, 60: 370-373. http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=60552141&site=ehost-live
    [23]
    张睿, 叶阿里, 孔令君, 等. 临床患者三种性传播疾病分子生物学检测分析[J]. 现代检验医学杂志, 2015, 30: 107-110.

    Zhang R, Ye AL, Kong LJ, et al. Clinical Molecular biology analysis of three kinds sexually transmitted diseases in patients[J]. Xiandai Jianyan Yixue Zazhi, 2015, 30: 107-110.
    [24]
    Moscicki AB, Ma Y, Holland C, et al. Cervical ectopy in adolescent girls with and without human immunodeficiency virus infection[J]. J Infect Dis, 2001, 183: 865-870. DOI: 10.1086/319261
    [25]
    McGrath JW, Strasburger VC, Cushing AH. Secretory IgA in cervical mucus[J]. J Adolesc Health, 1994, 15: 423-425. DOI: 10.1016/1054-139X(94)90268-2
    [26]
    Hickey RJ, Zhou X, Settles ML, et al. Vaginal microbiota of adolescent girls prior to the onset of menarche resemble those of reproductive-age women[J]. mBio, 2015, 6: e00097-15. DOI: 10.1128/mbio.00097-15
    [27]
    张岱, 刘朝晖. 生殖道支原体感染诊治专家共识[J]. 中国性科学, 2016, 25: 80-82. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201603029.htm

    Zhang D, Liu ZH. Consensus on the diagnosis and treatment of mycoplasma infection in genital tract[J]. Zhongguo Xingkexue, 2016, 25: 80-82. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201603029.htm
    [28]
    张帝开, 李秀云, 覃春容, 等. 健康妇女下生殖道解脲支原体及其分群分型研究[J]. 中国微生态学杂志, 2007, 19: 288-289. DOI: 10.3969/j.issn.1005-376X.2007.03.021

    Zhang DK, Li XY, Qin CR, et al. Detection of Ureaplasma urealyticum DNA expressions in cervix in healthy women and its biovars and serotypes[J]. Zhongguo Weishengtaixue Zazhi, 2007, 19: 288-289. DOI: 10.3969/j.issn.1005-376X.2007.03.021
  • Related Articles

    [1]ZHANG Shan, LIU Jie. Interpretation of NCCN Clinical Practice Guidelines for Primary Cutaneous Lymphomas (Version 1.2024) Based on the Current Diagnosis and Treatment Status of China[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(5): 1029-1037. DOI: 10.12290/xhyxzz.2024-0605
    [2]YAN Xinchun, HUO Li. Evaluation of Von Hippel-Lindau Syndrome Through Novel Small Molecular Tracer 68Ga-NY104 PET/CT Imaging[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 911-915. DOI: 10.12290/xhyxzz.2024-0216
    [3]ZHANG Ning, YANG Chenhao, ZHOU Liangrui, SUN Xiaohong, LIU Xiaohong, KANG Lin, LI Ji, LI Hailong. Cronkhite-Canada Syndrome Combined with Asymptomatic Novel Coronavirus Infection: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 406-412. DOI: 10.12290/xhyxzz.2023-0476
    [4]LIU Yuan, ZHAO Lin. Update and Interpretation of 2022 National Comprehensive Cancer Network Clinical Practice Guidelines for Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 999-1004. DOI: 10.12290/xhyxzz.2022-0271
    [7]Ming-sheng MA, Xü-de ZHANG, Min WEI, Shi-min ZHAO, Zheng-qing QIU. Efficacy of Low Dose Corticosteroid Therapy in Duchenne Muscular Dystrophy[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(4): 384-388. DOI: 10.3969/j.issn.1674-9081.2014.04.006
    [9]Jie LIU, Yue-ping ZENG, Chun-xia HE, Qin LONG, Hong-zhong JIN, Qiu-ning SUN. Corticosteroids plus Intravenous Immunoglobulin in the Treatment of 7 Cases with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 381-385. DOI: 10.3969/j.issn.1674-9081.2012.04.004
    [10]Shuai TANG, Jie YI, Yu-guang HUANG. Cardiovascular Responses of Intubation with Shikani Seeing Optical Stylet and Macintosh Laryngoscope[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(3): 314-317. DOI: 10.3969/j.issn.1674-9081.2012.03.015
  • Cited by

    Periodical cited type(13)

    1. 王妙,徐鹏,刘玉玲. 咸阳地区1347例患者解脲脲原体、沙眼衣原体及淋病奈瑟菌的感染特点分析. 临床医学研究与实践. 2025(02): 25-28 .
    2. 莫巧璇,黄声淳,邓秋萍,吴梓宁,吕微风. 泌尿生殖道病原体CT、UU和MG感染分析及相互影响的研究. 医学动物防制. 2025(05): 510-513 .
    3. 普良倩,周甜,李焱风. 非淋球菌性尿道炎男性患者解脲支原体、人型支原体的感染情况和抗生素耐药性研究. 中国性科学. 2025(02): 12-15 .
    4. 吴捷,林丽华,王碧,王皇玉,钟娜. 海南地区某门诊泌尿生殖道沙眼衣原体的感染及基因分型. 中国热带医学. 2024(03): 315-319 .
    5. 李翔,王陆颖,李颖佳. 生殖道衣原体和淋球菌感染在不孕不育人群中的分析. 中华预防医学杂志. 2024(08): 1236-1241 .
    6. 赵晓雯,刘朝晖. 生殖支原体感染与女性生殖系统疾病的研究进展. 标记免疫分析与临床. 2024(09): 1717-1722 .
    7. 张敏敏,陈蓉,王庆忠,徐蓉,刘学杰,崔琳,罗云桃,夏启航,钱诚凯,王敬华. 沙眼衣原体室间质量控制质控品的制备及其应用. 检验医学. 2023(01): 78-80 .
    8. 孙彤,王冬莲,陈微,陈佳喜,劳建萍. 浙江省台州市解脲支原体、沙眼支原体和淋球菌感染情况分析. 中国卫生检验杂志. 2023(05): 543-546 .
    9. 李茜瑶,徐敏,卢红艳. 2011-2021年北京市尖锐湿疣流行病学特征. 中国艾滋病性病. 2023(08): 922-923 .
    10. 陈怡颖,杨涵,陈怡蓉,王金凤,苏洪,戴欢欢,乔宇,张亚勤. 普洱地区男性不育症患者泌尿生殖道病原体感染现状分析. 现代医药卫生. 2023(19): 3312-3314+3319 .
    11. 刘孟涓,李秋红,李春莉. 重庆地区11284例患者生殖道沙眼衣原体与解脲脲原体检出情况分析. 西部医学. 2022(12): 1863-1867 .
    12. 冷欣颖,邹华春,付雷雯,柯吴坚. 2021美国CDC生殖支原体感染治疗指南读解. 皮肤性病诊疗学杂志. 2021(06): 487-492 .
    13. 雒宏烈. 3620例泌尿生殖道感染者解脲支原体DNA感染情况分析. 宁夏医学杂志. 2021(12): 1191-1193 .

    Other cited types(2)

Catalog

    Article Metrics

    Article views (902) PDF downloads (92) Cited by(15)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close