Volume 12 Issue 5
Sep.  2021
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HUA Yuwei, ZHAO Lin. Diagnosis and Management of Immunotherapy-related Liver Toxicity[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(5): 798-806. doi: 10.12290/xhyxzz.2021-0138
Citation: HUA Yuwei, ZHAO Lin. Diagnosis and Management of Immunotherapy-related Liver Toxicity[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(5): 798-806. doi: 10.12290/xhyxzz.2021-0138

Diagnosis and Management of Immunotherapy-related Liver Toxicity

doi: 10.12290/xhyxzz.2021-0138
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  • Corresponding author: ZHAO Lin  Tel: 86-10-88068315, E-mail: wz20010727@aliyun.com
  • Received Date: 2021-01-31
  • Accepted Date: 2021-03-12
  • Available Online: 2021-08-03
  • Publish Date: 2021-09-30
  • Immune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is very important to increase awareness and outline a clear and detailed strategy of managing immune-related liver toxicity. Some guidelines have published systematic advice on the management of immune-related liver toxicity. However, there are controversial problems remaining, including the levels of liver toxicity, the minimal effective dosage of hormone, treatments for hormone-refractory patients, and immunotherapy re-challenge. Additional, finding predictors with high specificity and sensitivity is a pressing concern.
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